Yet another company has made news this week for phase 2 trial progress. Concert Pharmaceuticals announced today that they have completed enrollment for their phase 2a trial using CTP-543 in alopecia areata. CTP-543 is an oral JAK inhibitor which acts on JAK 1 and 2, it’s also known as ruxolitinib. Concert’s version of ruxolitinib has been modified by the company’s proprietary deuterium chemistry technology which the company hopes will improve its effects on AA.

To us, that meant any product with zero proven ingredients, case studies, or FDA clearance — which shrunk our list by a whopping 180 contenders. That’s right, there are only three treatments that have actually been cleared by the FDA and supported with clinical studies: finasteride (commonly marketed as Propecia), minoxidil, and laser treatments. And, since finasteride is prescription-only, it left us with two.
Get the right style. For men who are suffering from pattern baldness, the easiest way to manage hair loss is to ask your barber for a style that will draw less attention to the thinning hair. Shorter hairstyles can reduce the impression of thinning hair, while a longer one can emphasize it. Others often make the mistake of growing their hair on the sides of their head as a way to cover up the thinning at the crown. This is wrong - it only calls attention to the bald spot. Instead, a clean cut on both sides will be better. Avoid also combing over some strands of hair the bald patch as an attempt to cover-up - it only draws attention to it.
“I was 21 when I noticed my hair getting thinner,” says David Anderson, 45, who has had seven hair transplants. He is now senior patient adviser at the Maitland Clinic in Liverpool, one of the country’s leading hair transplant clinics, where he raises awareness of the vulnerability of sufferers. “It was devastating. It completely consumed my existence. Now, I really regret that. But time and again, I’m meeting patients going through the same anxieties. It’s an epidemic. A lot of people don’t understand how it can make you feel.”
Tissue expansion. In this procedure, a material called a tissue expander is inserted under portions of the scalp with hair. Saline water is injected for six to eight weeks in order to expand or stretch this portion of hair-bearing skin. The bags are eventually removed and the expanded hair-bearing skin is cut away and moved to the adjacent bald area. This is typically used to address hair loss as a result of burns or injuries on the scalp.
After the new article featuring Medipost’s hair growth cosmetic was published, Jay Lee PhD of Medipost, began chiming in on the comments section. He first shared that Medipost is currently engaging in a larger clinical trial for the CM3 product which would include higher scale Norwood’s. Then, in a following comment he revealed that Medipost is developing a potentially more advanced hair growth product as well. Here are his words:
In the operating room, Bernstein prepped the robot patient for implantation, puncturing the man’s scalp with a long needle. These are the “sites” where the hairs will go. Blood bubbled over his scalp, but the patient didn’t seem to notice. The patient and doctor chatted loosely about summer houses and beers and boats. “Would I be a candidate for a surgery after this surgery?” he asked.
During a hair transplant procedure, a dermatologist or cosmetic surgeon removes tiny patches of skin, each containing one to several hairs, from the back or side of your scalp. Sometimes a larger strip of skin containing multiple hair groupings is taken. He or she then implants the hair follicle by follicle into the bald sections. Some doctors recommend using minoxidil after the transplant, to help minimize hair loss. And you may need more than one surgery to get the effect you want. Hereditary hair loss will eventually progress despite surgery.
They recommend using it up to 5 times a week for maximum effectiveness. Using it every day probably wouldn’t be a problem. You mean the Ultrax Labs Hair Solaye conditioner or conditioner in general? The company claims it works in conjunction with the shampoo and judging by the ingredient,s can also help to regrow hair to a small degree. But ketoconazole is way more important compared to other ingredients when it comes to treating hair loss, and the conditioner does not have it, so it’s not as important.
To us, that meant any product with zero proven ingredients, case studies, or FDA clearance — which shrunk our list by a whopping 180 contenders. That’s right, there are only three treatments that have actually been cleared by the FDA and supported with clinical studies: finasteride (commonly marketed as Propecia), minoxidil, and laser treatments. And, since finasteride is prescription-only, it left us with two. 

Yet another company has made news this week for phase 2 trial progress. Concert Pharmaceuticals announced today that they have completed enrollment for their phase 2a trial using CTP-543 in alopecia areata. CTP-543 is an oral JAK inhibitor which acts on JAK 1 and 2, it’s also known as ruxolitinib. Concert’s version of ruxolitinib has been modified by the company’s proprietary deuterium chemistry technology which the company hopes will improve its effects on AA.
The method for applying hair loss shampoo is the same as regular shampoo, i.e., you apply it to wet hair, massage it into the scalp and rinse it. The difference with hair-loss shampoos, however, is that you should leave them in for a longer time before rinsing. Doing so ensures that their ingredients reach your hair’s roots and scalp, where they have the biggest impact.
That said, hair loss isn't as bad or as hopeless as it sounds. It shouldn't be cause for added personal stress or social stigma, nor should it be something that should make us feel more self-conscious and less confident as individuals. With the advances in technology, you don't have to be saddled anymore with the uncomfortable choice of wearing an ill-fitting, unnatural-looking hairpiece. There is now a wide array of options available to treat and cure hair loss, whether temporary or permanent.
7/26/18 Update: After positive early data, various trials of JAK inhibitors such as Ruxolitinib and Xeljanz are underway. Columbia researchers have had positive results with Xeljanz in 11 out of 12 subjects achieving some regrowth with no adverse side effects over 16 months of treatment. Investigators at Stanford and Yale are conducting three trials of oral and topical tofacitnib and Locks of Love Foundation is fuding another ruxolitinib study. At this time, there are about 15 publications looking at JAK inhibitors and their relationship to alopecia and its variants.
In most cases though, it's all a matter of attitude. Being bald should not be a cause of stigma. It does not make you less of a person or less masculine, less virile, and less attractive and appealing. In fact, a clean shaven head is becoming a popular trend among men these days, and there are certainly many bald men who have managed to make themselves look clean, elegant and suave despite their hair loss. Learn to come to terms with it. It's hair loss, yes, but not brain damage. It does not affect your core.
We know our products deliver the intended results for the overwhelming majority of men and women who use them as directed. How do we know this? Because we have witnessed the results first-hand on customers of every age, race, and hair type. Because we've spent over 10 years developing, evolving and continually perfecting functional hair care products just like this. Because the Veta product line was tested, piloted and proven at select A-list salons prior to being launched to the public.
“I also reached out to Histogen and Follicum a few weeks ago as well thanking them for all their hard work in bringing a safe and effective treatment to people all over the globe with hairloss issues and expressed how much we all value these companies. I held back from asking about market release as you had suggested. I received a very nice reply from Histogen.”
Other therapies for the treatment of alopecia areata include topical mid- to high-potency corticosteroids, minoxidil, anthralin, immunotherapy (diphenylcyclopropenone, squaric acid dibutylester), and systemic corticosteroids.12 Currently available therapies often yield unsatisfactory results, and some clinicians rely on the high rate of spontaneous remission or recommend a hairpiece or wig if remission does not occur.13
The third and fourth stages are known as telogen and exogen, respectively. In telogen, the hair is supposed to be at "rest" until it finally detaches itself from the follicle and enters the exogen or shedding stage. Once the hair is detached from the follicle, the follicle remains inactive for about three months, after which a new cycle begins again.
×