Follicum announced yesterday it has successfully completed the development of a topical formulation for FOL-005. The company had been working in parallel to develop an optimal topical version of FOL-005 while an injectable version of the peptide was being used in a clinical trial. Now that the topical formula is completed it will be trialed in a further phase 2 clinical trial which will likely begin very late 2018 or early 2019.
Hair loss is common in men as they grow older although it can affect them at any age. This can speed up for many different reasons although hormone related male pattern baldness is the most common of these.  The most common symptom for men is a receding hairline, you can combat further receding with treatments ranging from oral supplements, prescription serums, and shampoos.  We have a guide to the best hair growth supplements that has additional information
Choosing where and who will perform your hair transplant is as important a consideration as to what kind of hair transplant to get. Of utmost consideration is that this should be done by the dermatologist /surgeon, and not his/her technician. The surgeon himself/herself should also oversee the design of your hairline and how the extraction of the graft will be done.
Due to the concern of several readers, I’ve removed the link to the new Trinov website that has popped up on the net. For now, the website only contains an email address subscription box which really poses no issue to anyone who subscribed. At this time, it’s not confirmed who the actual owner of the new Trinov site is, so use your discretion until we find out more regarding this matter. Until more information is known the website will not be shared on Follicle Thought.
Hair is made up of the hair follicle (a pocket in the skin that anchors each hair) and the shaft (the visible fiber above the scalp). In the hair bulb, located at the base of the follicle, cells divide and grow to produce the hair shaft, which is made from a protein called keratin. Papilla that surround the bulb contain tiny blood vessels that nourish the hair follicles and deliver hormones to regulate the growth and structure of the hair.
The trick about all of these hair-loss products and treatments is that they’ll stop working as soon as you stop using them. “They have to be ready for a lifetime commitment,” says Rieder. But, just like brushing your teeth, as long you keep on keeping on with the scientifically proven preventative treatments, those hairs on your head should be just fine.

Keranique is another line of products targeted towards women. They offer a complete system consisting of shampoos, conditioners, and topicals. Our testers found that it was one of the harshest shampoos and was not always color safe. Their topical foam contains Minoxidil which can irritate some scalps. Keranique hair products are safe to use and highly effective.  They also have an anti-dandruff shampoo that has received amazing reviews.
But, there’s an even more important step to take – your participation and contribution. The topic of “a cure for hair loss” or “a hair growth treatment”, for many of us, is one of the most important issues in our lives. What are you doing to support its success? I realize that question may not have previously crossed the mind for many. It’s here now. For a personal example, I’m not a scientist who creates molecules in a lab, so I decided I would organize the hair growth treatment news and spread awareness. It’s been a gratifying practice for me. 
Laser treatments. Low-level laser therapy (LLLT) is used for the prevention and reversal of hair loss. Also known as red light therapy, cold laser, and soft laser, it is a form of light/heat treatment (therefore generally safer) that is used on cases of pattern baldness and alopecia areata. The procedure uses a device that emits light that penetrates into the scalp. The more commonly used lasers are the excimer, helium-neon and fractional erbium-glass. The procedure can increase the blood flow in the scalp to stimulate the follicles that are in resting or dormant phase to go into anagen, and at the same time, prevent the production of DHT, which destroys the hair follicles.
In my opinion this shampoo has a "manly" smell. No flowers or sweet smells which is ok. Maybe it's an herb smell. Its not too overpowering and its a scent that is acceptable to both of us which is nice since my husband and I are both using this shampoo. He is real impressed with it and says his hair feels softer. He also thinks it is getting thicker on the top. I see him every day so I'm not sure I notice it. We have only been using it for a month or two so I don't really think that's enough time to see drastic improvement. I did notice the other day that he needs a hair cut so it may be that his is growing faster. I also noticed that I have little short hair sticking up all over my head so I obviously have new growth! I haven't really noticed a reduction in the amount of hair that I am losing but I am so excited to know that I have new hair coming in. I will be 50 this year and my husband is 51 so I know that our hair loss is a normal aging thing but neither of us like it and have tried several different shampoos looking for something that will stop the hair loss. I guess if we can't stop it we'll settle for new growth! Our first bottle of Biotin Shampoo is almost empty and I have decided to get another bottle instead of moving on to something else. This stuff is definitely worth staying with for a while to see how much the hair growth and reduction will improve.
But in November, after 10 years of research, Rogaine introduced a new 5 percent minoxidil formulation for women. It’s a mousse (instead of a liquid) that needs to be applied only once a day instead of twice, which means that it can be more easily incorporated into a woman’s evening skin-care routine. Teal replaces the blue and silver palette of the men’s Rogaine, and the packaging bears a lotus flower. (Also last year, Pantene introduced its Hair Regrowth Treatment for Women, which is 2 percent minoxidil.)
“Everyone wants to try it,” Altman told me. “We get inundated with e-mails saying, ‘Tell me what the price is, I really don’t care, I’ll buy it.’ ” Weinstein looked at me. “You have your hair,” he said. “I don’t know why you’re interested in this,” Altman chimed in, with wildly unrealistic but much appreciated enthusiasm for my reporting. “ ’Cause eighty million people don’t! There’ll be eighty million people reading this article!”
Disruptions in the normal length of each phase, which can cause hair loss and hair thinning, may be the result of a number of internal and external stimuli. These are also what we call the triggers and causes of your hair loss. As a quick example, dieting can leave the body stressed and in need of important nutrients. Because of this stress, hair growth may be cut shorter than usual and there is an early onset of telogen or shedding of hair.
I am a 45 yr female that has experienced hair loss to the point of having to hire a plumber twice (over 3 years) to unclog our drain in our main bathroom although I am pretty cautious about picking up my hair. My ponytail is about 1/2 the size that it was 5 years ago. i had excessive hair loss after the birth of my last 2 of 3 children. It is noticeably thinner although my employees, friends and husband seem to think my hair is thick. I can see my scalp very easily. (No patchy alopecia though) I started using viviascal professional strength about 2 months ago and hair surge shampoo only about 2 weeks ago. The bottle has about 1/3 left and i am wondering what is to be expected from this product. I have to use at least 8 pumps ( it seems to be double the volume of normal shampoo that i use) and it does not seem to later that well until after a min or so. Additonally i am using the hair surge supplement. When should i see less hair falling out? When should i expect visible results. Any other suggestions? I know it says to use 5 of 7 days, but i use it daily to make sure i am getting the full benefit ( if any) from this product. Currently i am looking at 100 buck a month for the shampoo alone if i keep this up. Any advice is welcome. Thanks
Argan oil is loaded with A, C and E vitamins, all of which have been linked to hair growth. When you use argan oil externally as part of a hair loss shampoo, it can help to boost your scalp’s and skin’s cell production, thus causing healthier hair and skin. Argan oil is good for dry, brittle and thinning hair since it guards against you losing more follicles than you’re capable of growing (which makes hair loss noticeable).
Treatment for adults with less than 50% of scalp involvement is intralesional triamcinolone acetonide injected intradermally using a 0.5-inch, 30-gauge needle. Maximal volume is 3 mL per session.11 Treatment may be repeated every four to six weeks until resolution or for a maximum of six months. Local adverse effects include transient atrophy and telangiectasia.
“If you don’t want a scar because you like to wear your hair short, you might opt for a “scarless” hair transplant,” says Dr. Joyce. Also known as follicular unit extraction (FUE), grafts are harvested one at a time with tiny punches that heal virtually undetected so you can still buzz your head. “If you’ve gone so bald that you don’t have a lot of donor hair on your head, we can do FUE extractions with body hair such as on your chest, stomach, back, and sometimes even the pubic area,” says Dr. Joyce.
What is one thing you can do to help new hair growth treatments become a reality? Be creative. Your activity, whatever it might be, will give you a sense of empowerment. You will be contributing to the goal of new hair growth treatments becoming available in the world. How could you feel apathetic or helpless when you are taking the initiative to get involved? Please share in the comments of this page your ideas or practices for how you personally choose to contribute to the success of new hair growth treatments becoming a reality. Remember, every idea or action is worthwhile and supports the outcome. Be authentic and best wishes. Thank you
A diet that is poor or lacking in certain nutrients, particularly iron, protein, and vitamin B, which are essential in the production of keratin, can cause a long telogen phase and a very short anagen stage. On the other hand, excess supply of vitamin A in the body, especially those taken through supplements, can prove to be toxic and can cause a range of adverse body effects including loss of appetite, fatigue and consequently, hair loss.
Coconut milk / coconut oil. Coconut milk/oil, like aloe vera, is one of the oldest and most common natural ingredients for promoting hair growth and growing healthy, shiny hair. Coconut is rich in protein, iron and other minerals that promote healthy hair and prevent breakage. Apply the coconut milk/oil on your bald spots or all over the scalp, and leave it on overnight. Rinse the next day with cool water. You can do this every time you wash your hair.
A few studies support the use of red ginseng, sometimes called panax ginseng (about $25), for hair regrowth. It can have an anti-apoptotic effect on the hair, Rogers says, meaning it slows cell death so hair follicles can grow for a longer period of time. But before taking any of these supplements, it’s important to consult your doctor; a lab test can confirm whether you need a particular supplement or if taking it will just be a waste of time and money.
Blow dryers, flat irons, and other devices: Frequent use of a blow dryer tends to damage hair. The high heat from a blow dryer can boil the water in the hair shaft leaving the hair brittle and prone to breakage. Dermatologists recommend that you allow your hair to air dry. Then style your hair when it is dry. Dermatologists also recommend limiting the use of flat irons (these straighten hair by using high heat) and curling irons.
This super-clean (and paraben- and sulfates-free, non-GMO, and vegan) shampoo zones in on the hair-saving supplement you’ve been hearing about for years: biotin. Nature’s Gate pairs its key ingredient with bamboo, a silica-packed scalp cleanser, and follicle-fortifying pro-vitamin B5. “I have thin hair that was breaking off and clogging my drain,” one reviewer wrote on Amazon. “No longer ... I may not have thick hair but it is stronger after using this shampoo.”
Patel said the problem with those treatments is that they have not been subjected to large or head-to-head research. There's great variation in how doctors give the plasma treatments and in laser-based devices, so it's hard for patients to know whether they're getting a proven regimen. Nutrafol seems promising, he said, but he does not think that company-funded research showing its effectiveness has been replicated. He has not recommended it yet.
I am a 45 yr female that has experienced hair loss to the point of having to hire a plumber twice (over 3 years) to unclog our drain in our main bathroom although I am pretty cautious about picking up my hair. My ponytail is about 1/2 the size that it was 5 years ago. i had excessive hair loss after the birth of my last 2 of 3 children. It is noticeably thinner although my employees, friends and husband seem to think my hair is thick. I can see my scalp very easily. (No patchy alopecia though) I started using viviascal professional strength about 2 months ago and hair surge shampoo only about 2 weeks ago. The bottle has about 1/3 left and i am wondering what is to be expected from this product. I have to use at least 8 pumps ( it seems to be double the volume of normal shampoo that i use) and it does not seem to later that well until after a min or so. Additonally i am using the hair surge supplement. When should i see less hair falling out? When should i expect visible results. Any other suggestions? I know it says to use 5 of 7 days, but i use it daily to make sure i am getting the full benefit ( if any) from this product. Currently i am looking at 100 buck a month for the shampoo alone if i keep this up. Any advice is welcome. Thanks
We have yet another biotech research company working on a next-gen hair growth cosmetic product. Their webpage mentions the use of “stem cell culture solution-derived proteins” for hair growth cosmetic products. An imminent release of the product seems unlikely, however it is nice to know how many companies really do want us to have a new product to improve our lives. Website here.
Because hair concealers work like wigs, choosing one that's right for you is important. More than anything, it should be as natural looking and as subtle as possible. Pick one that matches your natural hair color. Most hair fibers come in nine colors, and if you want to achieve a good color fit, you can blend two colors. Apply first the dark color and then the lighter color.
Happy Friday from Follicle Thought and I hope you are enjoying March Madness basketball. That being said, please also enjoy this video of Deion Sanders, NFL Hall of Famer who recently had a 5,000+ FUE hair transplant, showing off his new grown-in hairline. Video was posted by his barber. With all the technical details and the day-in, day-out watch for new hair growth technology it is important we take a moment to enjoy the lighter side of things. Sit back and “get a side shot of that thing.” 😂
And just like that, more fascinating hair-related research was published in PLOS Biology. A team of researchers lead by Dr. Nathan Hawkshaw of the University of Manchester have identified the drug ‘WAY-316606’ as a potential candidate for hair regrowth. WAY-316606 is an existing drug used to treat osteoporosis. It’s not clear at this time whether WAY-316606 is approved and on the market, or if it was partially developed to treat the bone disease.
Laser devices: Brushes, combs, and other hand-held devices that emit laser light might stimulate hair growth. These devices might make hair look more youthful in some people. Because the FDA classifies these products as medical devices, the products do not undergo the rigorous testing that medicines undergo. The long-term effectiveness and safety for these devices are not known.

Hair transplant/surgery. A hair transplant or surgery is the quickest treatment for permanent cases of hair loss, although the most expensive. In pattern baldness, for example, where the top of the head is the most affected area, a hair transplant allows the surgeon to use existing hair to implant it into the bald sections of the head. It works by removing a graft or follicular sample in parts of the head that still have hair (usually this is the back of the head as this area is most resistant to hormonal changes), and placing this graft in the areas that are bald.


“Smelling” Receptor Keeps Hair Growing – Many of you may have noticed the headlines regarding sandalwood and hair growth over the past week. The research everyone is talking about comes from Ralf Paus and his team at the Monasterium Laboratory GmbH. For the record, Paus is also the main researcher behind the WAY-316606 hair growth discovery. This time Paus et al identified an olfactory receptor in hair follicles, OR2AT4,  which plays a role in regulating hair growth or inhibition. Olfacory receptors are responsible for detecting odors in cell membranes and provide the basis for our sense of smell, they do carry out additional functions though, as demonstrated by Paus. 

Key features: The Dove Dermacare anti-dandruff 2-in-1 shampoo and conditioner is a solid option for dandruff management that's also super affordable. For $15, you'll get not one, but two bottles. Its active ingredient is pyrithione zinc, an anti-fungal ingredient commonly used to treat psoriasis that Dr. Zeichner recommendeds for dandruff. The formula is effective in treating scalp dryness and flakes because of it, and it has a refreshing mint scent.
To see if ShippingPass is right for you, try a 30-day free trial. Also, with ShippingPass, there is no need to worry about commitment. If you decide you want to discontinue the service, you can cancel your subscription at any time. No matter what your shipping needs, Walmart's got you covered. Sign up for ShippingPass so you can shop more, save money and live better.
In fact, research posted in the Journal of Dermatology found that ketoconazole was effective in treating mice for dermatitis and hair loss. In clinical trials, researchers found that 15 men who used finasteride, minoxidil, and ketoconazole for a 90-day period benefitted from hair growth, getting a noticeably thicker head of hair than what they had at the beginning of the studies.
Finasteride (brand name Propecia) is the closest to a hair loss cure pill that scientists have discovered to date. This is a DHT hair loss cure. DHT is made when 5 alpha reductase converts testosterone, and Propecia has been found to be an effective inhibitor of DHT by preventing this process from happening. It works internally, at the root of the cause. Therefore, DHT sensitive hair follicles in the front and top of the scalp don’t have to fight off nearly as much DHT.
Certainly a company with a unique background and game plan, HairClone has received some recent media attention. The UK biotech startup was featured in this month’s publication of “Consulting Room” online magazine. In the article both Dr. Bessam Farjo and Paul Kemp of HairClone provided insight as to the company’s current progress and plans for the future. Things seem to be coming along well for HairClone and we should expect to hear from them again within the next several weeks. Full story is on Articles main page.
Follicular Unit Extraction (FUE). In this method, instead of taking out a whole sample strip, small, individual follicle grafts are cut using a machine and then transplanted. The process is more tedious and more time-consuming, but has been known to have a higher recovery rate and there are no risks of scarring because no cuts and stitches are required.
It is no surprise that Donald Trump is obsessed with hair loss. “Never let yourself go bald,” he once told a Trump Organization executive. “The worst thing a man can do is go bald.” During their brief dalliance, Stormy Daniels confronted him about his hair. “I was like, ‘Dude, what’s up with that?’ ” she said, to In Touch, in 2011. Trump laughed. Then he told her that he worried that “if he cut his hair or changed it, that he would lose his power and his wealth.” Recently, Trump’s physician admitted that the President takes the anti-baldness medicine Propecia.
McElwee is an associate professor in the Department of Dermatology and Skin Health at the University of British Columbia (UBC) in British Columbia, Canada and director of the Hair Research Laboratory in the Vancouver Coastal Health Research Institute (VCHI) at Vancouver General Hospital (VGH). A hair research scientist, McElwee is one of only a small group of research scientists worldwide who studies hair biology and associated diseases.
Pura d’or makes a very bold claim with this product: “continued use WILL prevent further hair loss.” While we doubt it will “prevent further hair loss” for everyone, it does have an all-star line up of ingredients. Even if it doesn’t completely stop hair loss, this organic shampoo is certainly the safest for your hair out of our top 5. This shampoo is designed for daily use.
This super-clean (and paraben- and sulfates-free, non-GMO, and vegan) shampoo zones in on the hair-saving supplement you’ve been hearing about for years: biotin. Nature’s Gate pairs its key ingredient with bamboo, a silica-packed scalp cleanser, and follicle-fortifying pro-vitamin B5. “I have thin hair that was breaking off and clogging my drain,” one reviewer wrote on Amazon. “No longer ... I may not have thick hair but it is stronger after using this shampoo.”
"Others are taking hair follicles out of human scalp and growing them with dermal papilla cells," Cotsarelis says. "If they grow in culture, you might be able to recombine them with skin cells and form new follicles. This would let you expand the number of follicles you get for a hair transplant. This may not be that far off -- five to 10 years, maybe. There's very good evidence you will be able to do that."

Pura d’or also have a hair loss conditioner compliment to this shampoo but we think it’s a bit overkill to use both(as a bottle of this stuff runs on the pricey side)—but if you love the shampoo the conditioner is also a very popular product that couldn’t hurt. Leave it in for about 3 minutes and let your scalp absorb all those vitamins and minerals.
Literally jumping right out of the woodwork, the company “HCell” has announced they have been granted an orphan designation from the US FDA for their novel treatment of pediatric alopecia areata. The treatment itself it described as a “topical Injection by regenerating hair through a proprietary blend of commercially procured biologic and autologous tissue.” The company also mentions having a treatment for androgenic alopecia in the works as well. More info to come soon. News release here. 
At the Sanford-Burnham Medical Research Institute, they showed that stem cells derived from human skin to grow hair when grafted onto the skin of mice. A paper describing this research, which was published on January 21st 2015 can be found here in the PLOS One medical journal. Dr. Alexey, a member of the research team made the following written statement: “Our stem cell method provides an unlimited source of cells from the patient for transplantation and isn’t limited by the availability of existing hair follicles.” Once successfully developed, this could transform a fully bald man or woman to the head of hair they had as a teenager. The main challenge now will be replicating their results in large-scale human trials.
As the name suggests, androgenetic alopecia involves the action of the hormones called androgens, which are essential for normal male sexual development and have other important functions in both sexes, including sex drive and regulation of hair growth. The condition may be inherited and involve several different genes. It can also result from an underlying endocrine condition, such as overproduction of androgen or an androgen-secreting tumor on the ovary, pituitary, or adrenal gland. In either case, the alopecia is likely related to increased androgen activity. But unlike androgenetic alopecia in men, in women the precise role of androgens is harder to determine. On the chance that an androgen-secreting tumor is involved, it's important to measure androgen levels in women with clear female pattern hair loss.
Some 30 million women in the United States have hereditary hair loss (compared with 50 million men), according to the American Academy of Dermatology, though that figure does not include the millions more who struggle with thinning hair because of pregnancy, menopause, stress and other health conditions. Barely 5 percent of women are said to be good candidates for hair transplant surgery because women lose hair everywhere, meaning that, unlike with men, there is rarely a luxuriant spot on the back of the head from which to harvest hairs unobtrusively. 

Hair: It’s a natural part of being a human. But when the temperature climbs, and skin is exposed, it’s one of those things that a good many of us want to control. This week, we’re tackling hairlessness, not just the process of hair removal (electric shavers and ingrown-hair treatments and aesthetician-approved tweezers) but also what to buy when you’re losing your hair, and even how to take care of a Sphynx cat. Here, we’re talking to dermatologists and hair-loss doctors about hair-loss treatments that actually work.

The pull test may be used to diagnose hair loss conditions.1 The examiner grasps approximately 40 to 60 hairs at their base using the thumb, index, and middle fingers and applies gentle traction away from the scalp. A positive result is when more than 10% of hairs (four to six) are pulled from the scalp; this implies active hair shedding and suggests a diagnosis of telogen effluvium, anagen effluvium, or alopecia areata. However, a negative test result does not necessarily exclude those conditions. The pull test is difficult to standardize because the pulling force is not distributed uniformly and because it is difficult to approximate the number of hairs grasped, thereby leading to false interpretations.
We’re not exactly sure about that “growth potential” stuff; for our purposes, the question is whether the product works to stop hair loss. Several of the confusing phrases the company uses actually address that question. The shampoo works to protect mitochondrial DNA, an important component in protecting and growing hair follicles, with fatty acids. It also contains ingredients which prevent further damage to the follicles. In other words, it protects and strengthens the hair you already have.
SOURCES: George Cotsarelis, MD, director, Hair and Scalp Clinic, University of Pennsylvania School of Medicine, Philadelphia. Andrew Kaufman, MD, assistant professor, department of dermatology, University of California, Los Angeles; medical director, Center for Dermatology Care, Thousand Oaks, Calif. Tom Barrows, PhD, director of product development, Aderans Research Institute Inc., Atlanta. Cotsarelis, G. and Millar, S.E. Trends in Molecular Medicine, July 2001; vol 7: pp 293-301. American Society for Dermatologic Surgery web site. American Academy of Facial and Reconstructive Plastic Surgery web site. American Hair Loss Council web site. Springer, K. American Family Physician, July 1, 2003; vol 68: pp 93-102. Hair Loss Help web site, "Interview with Dr. Ken Washenik from Bosley." Fuchs, E. Developmental Cell, July 2001: vol 1: pp 13-25.
Finding the best hair loss shampoos for men can sometimes feel like a wild goose chase. In this article, We have done the heavy lifting for you and identified the best options and put them alI in one place. Interested in keeping that silky mane flowing strong? Shampoo is a big part of how you care for those luscious locks and the scalp underneath. It makes sense that you wouldn’t want to use just any shampoo, especially if you’re battling balding. Your hair deserves better. Read on my friend.
Beware online stores selling Propecia without a prescription.Finasteride is FDA approved, but buying it online without a prescription can be illegal and dangerous. Prescription-free online stores have a reputation for selling placebos or dangerous replacements. We recommend speaking with a doctor about prescriptions or sticking to save over-the-counter treatments.
“If you don’t want a scar because you like to wear your hair short, you might opt for a “scarless” hair transplant,” says Dr. Joyce. Also known as follicular unit extraction (FUE), grafts are harvested one at a time with tiny punches that heal virtually undetected so you can still buzz your head. “If you’ve gone so bald that you don’t have a lot of donor hair on your head, we can do FUE extractions with body hair such as on your chest, stomach, back, and sometimes even the pubic area,” says Dr. Joyce.

Other therapies for the treatment of alopecia areata include topical mid- to high-potency corticosteroids, minoxidil, anthralin, immunotherapy (diphenylcyclopropenone, squaric acid dibutylester), and systemic corticosteroids.12 Currently available therapies often yield unsatisfactory results, and some clinicians rely on the high rate of spontaneous remission or recommend a hairpiece or wig if remission does not occur.13
Follicle Thought is pleased to announce a new sponsor of this website, Hair Restoration Laboratories, LLC. The company produces quality anti-DHT shampoo and conditioner products. I have reviewed the ingredients of the shampoo and conditioner and find them to be very thoughtful and well researched. Also important to scalp health, the products contain no sulfates, no parabens, no silicones and no artificial ingredients. 
When you're investing considerable time and money on a mix of hair treatments and cures, the last things you should be doing are those that will only aggravate your condition. Likewise, when your hair has finally grown back, the last thing you would want is for you to go through another horrific episode of hair loss. Preventing further - or another case of hair loss, and stopping it before it actually happens should be your goal.
Besides cost considerations, a hair transplant is generally prescribed as a last resort for permanent hair loss problems. It is also not allowed for people under the age of 25, those with a continuing problem of hair loss, as well as those with other health conditions like uncontrolled diabetes, serious heart problems and hypertension. Patients whose hair loss is caused by other factors, such as a skin or scalp disorder or who suffer from a psychological condition that causes them to pull at their hair are not recommended for this procedure. Since the procedure requires taking a sample from the back of the head, those who do not have enough follicles from this section that can be used for transplant are not also eligible.
Yesterday marked the “estimated study completion date” for setipiprant’s phase 2a trial in androgenetic alopecia in males. The participants of the trial received 1000 mg of setipiprant by oral tablets twice a day over a 6 month period. I expect the results to be presented sometime in 2nd half 2018. Here’s to hoping for positive results from this trial and expediency in beginning a phase 2b or phase 3 trial for setipiprant. Clinical trial page here.
Hair grooming, but more importantly, having a head-full of hair is as important to men as it is to women. To women, it may be an important accessory of beauty, and for men, it adds to a sense of manliness, enhances their looks and makes them more appealing and attractive to women. Balding to men is associated with aging (only old men are expected to lose hair) and therefore, having hair on one's head is a sign of virility and masculinity.
I must have had about 5 readers email me today about the fascinating research coming out of Yokohama National University in Japan. Professor Junji Fukuda lead the efforts to successfully prepare “hair follicle germs” at large scale simultaneously. Essentially, the researchers prepared a cellular formulation with the right culturing materials to promote successful growth and development of tiny “hair follicle starter kits.” Source article here. 

Key features: Dr. Zeichner recommends the Keratin Oil Shampoo and Conditioner by OGX for thinning or fine hair that needs the extra strength. This budget-friendly option uses keratin proteins mixed with argan oil to nourish, condition, and strengthen strands, and it's only $16 for the set. The smoothing formula can also increase elasticity for less breakage and split ends.


I am a 45 yr female that has experienced hair loss to the point of having to hire a plumber twice (over 3 years) to unclog our drain in our main bathroom although I am pretty cautious about picking up my hair. My ponytail is about 1/2 the size that it was 5 years ago. i had excessive hair loss after the birth of my last 2 of 3 children. It is noticeably thinner although my employees, friends and husband seem to think my hair is thick. I can see my scalp very easily. (No patchy alopecia though) I started using viviascal professional strength about 2 months ago and hair surge shampoo only about 2 weeks ago. The bottle has about 1/3 left and i am wondering what is to be expected from this product. I have to use at least 8 pumps ( it seems to be double the volume of normal shampoo that i use) and it does not seem to later that well until after a min or so. Additonally i am using the hair surge supplement. When should i see less hair falling out? When should i expect visible results. Any other suggestions? I know it says to use 5 of 7 days, but i use it daily to make sure i am getting the full benefit ( if any) from this product. Currently i am looking at 100 buck a month for the shampoo alone if i keep this up. Any advice is welcome. Thanks
When you're investing considerable time and money on a mix of hair treatments and cures, the last things you should be doing are those that will only aggravate your condition. Likewise, when your hair has finally grown back, the last thing you would want is for you to go through another horrific episode of hair loss. Preventing further - or another case of hair loss, and stopping it before it actually happens should be your goal.
In the initial decade after the first identification of the hedgehog gene around 1980, there was almost no research devoted to the impact of the SHH pathway upon human hair. However, this started to change in the mid-1990s (e.g., this from 1998) and culminated in the seminal work on this subject that was published in the US in 1999: “Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog“.
Best hair loss treatment shampoo for women and men is made with natural, herbal ingredients that promote a healthy scalp and hair follicles. We use no sulfates, no parabens and no harmful ingredients. Our formula is safe for color treated hair as well as processed and natural hair. We avoided using any additives instead opting for ingredients found in nature so our hair is safe for all hair types and textures, no matter your age. Our dandruff and hair loss prevention shampoo goes to the root of the issue repairing the scalp instead of just covering the symptoms.

This is a bestselling shampoo on Amazon. The list of ingredients is extremely lengthy. The product contain a number of natural organic DHT blockers (including saw palmetto) and various nourishing hair vitamins. Additional beneficial ingredients include amla oil, argan oil, pumpkin seed oil, rosemary oil, tea tree oil, green tea extract, niacin and biotin.
There’s no cure for baldness, but there are ways to hold on to what you've got. The six dermatologists and the clinical studies point to three methods: minoxidil, laser treatments, and prescription finasteride. The key is finding the combination and hair loss regimen that works for you. A doctor is your best bet for that kind of guidance — but we found a few trustworthy products that will work for most people.
Lately I’ve been receiving a few inquiries from readers about Shiseido and Brotzu release dates. So, I’m going to address the situation here and hope that this will be sufficient until more news comes from direct sources. I estimate that these companies would publicly address the release date of their products by the end of Q3 this year (end of Sept). As consumers we know there’s no guarantees for releases and if one or both of these products reached the market this year it would be a very fortunate situation. So, keep an eye out, but loosen the grip a little. The news will come when it comes. When there is news it will be visible here.
“The DHT hormone (dihydrotestosterone) can contribute to thinning in women who are genetically predisposed to female pattern thinning,” Fusco says. For those whose case falls into this category, she advises a prescription shampoo with ketoconazole 2 percent, as it has anti-androgenic properties. “Ketoconazole has been proposed to disrupt the pathway of DHT leading to thinning of follicles.”
Chronic dandruff can also lead to hair shedding if it’s left untreated or undertreated. “Many women with dandruff don’t use a dandruff shampoo regularly because they are concerned with the lack of cosmetic elegance and the concern that it won’t beautify their hair,” Fusco explains. “A dandruff shampoo and conditioner that contain ZP [zinc pyrithione] and ingredients that beautify the hair can be used every day, as they will control dandruff, reduce inflammation, and thereby diminish shedding.”
One friend who went bald in his early 20s said that even once he’d readjusted to his new look, the thing that saddened him was that this look would define him pretty much for ever. Another, now in his 40s, found it dispiriting when his hair started falling out in his 20s – “the first sign that my youth was fading…” He decided against Minoxidil and Finasteride – “If I recall correctly, one of the side effects was impotence or diminished libido, which didn’t seem a good trade-off” – and found the idea of surgery “laughable”, so opted to shave it all off, finding some cheer in the new-found solidarity among his fellow balding friends. Still, he says, anti-bald prejudices are real.
There have also been studies on the effects of 1% pyrithione zinc shampoo and a 5% minoxidil solution. In one study, 200 men between the ages of 18 to 49 who experienced baldness between type III and type IV on the Norwood scale were given this treatment for a six-month period. They found that minoxidil, when used on its own, was approximately twice as powerful as pyrithione zinc at stimulating hair growth, but that both products were successful at increasing the amount of visible hair when used over a 26-week period.
Taking hair supplements can be helpful for anyone who is experiencing hair loss or hair thinning. Dendy Engelman, MD, a board-certified dermatologic surgeon at Medical Dermatology & Cosmetic Surgery in New York City, previously recommended Nutrafol, a research-backed hair supplement, to Prevention. "This uses highly concentrated botanicals to address every stage of the growth cycle," she says. Nutrafol's hair supplements include vitamin E and ashwagandha (an adaptogen that helps balance cortisol levels in the body), among others.
However, the high incidence of androgenic alopecia is caused by the male hormones. Testosterone in the scalp is converted into dihydrotestosterone (DHT) that causes the follicles to shrink in size, therefore inhibiting the growth of hair, which eventually leads to baldness. However, hair follicles on the sides and back of the head do not have as much DHT compared to the top, hence why hair loss is concentrated on the crown of the head. Interestingly, DHT is known to help in the growth of the beard and hair on the chest, a reason why most bald men have hairy chests and grow their beards much faster.
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