The key ingredient in Nizoral is ketoconazole, which reduces hair follicle inflammation that contributes to hair loss. Ketoconazole also kills fungi that cause dandruff, but there’s not so much of it as to be toxic (which large amounts of ketoconazole can be). It has been argued that dandruff may contribute to hair loss; while there’s no direct link, it’s certainly worth noting here.
“Curis (now-dormant company) had performed a lot of studies on targeting the Hedgehog pathway for hair growth with very promising results, however, their compounds caused orthosteric activation of the pathway (turning it on everywhere and robustly which is not safe) vs. Oxy133 which causes a much more regulated and limited allosteric activation of the pathway only in stem cells. This could make Oxy133 a blockbuster. Let’s see what happens.”
Men’s Rogaine Extra Strength Solution is the liquid version of our top pick. It didn’t make our final cut because it includes propylene glycol, which causes irritation in roughly one-third of its users. With that said, Dr. Wolfeld finds that it can be even more effective in practical daily use. In his experience, “the solution can penetrate and get into your scalp a little bit better” than the foam — especially if you’re not taking the time and effort to apply the foam correctly. This seems crazy to us since the foam so quickly dissolved into a liquid in our tests, but if you’re worried, try a one-month supply of the liquid and make the switch to foam if you notice any irritation.
Many pharmaceutical companies and researchers are in the search for a hair loss cure. This is because 7 out of 10 men and 4 out of 10 women suffer from androgenic alopecia (genetically caused hair loss) in their lifetime. In the United States that amounts to around 80 million men and 40 million women currently suffering from hair loss. Of course, a permanent cure would relieve a huge percentage of the population.
Literally jumping right out of the woodwork, the company “HCell” has announced they have been granted an orphan designation from the US FDA for their novel treatment of pediatric alopecia areata. The treatment itself it described as a “topical Injection by regenerating hair through a proprietary blend of commercially procured biologic and autologous tissue.” The company also mentions having a treatment for androgenic alopecia in the works as well. More info to come soon. News release here.
Hair loss is not a hopeless condition. While there are certainly cases of permanent hair loss in men, there are still cases when it's only temporary and therefore can be treated, controlled and prevented. There are treatments and cures available, and many of these, especially those for temporary cases, can be as simple as lifestyle changes -- eating the right foods, learning to manage stress properly, and doing away with unhealthy, nasty habits that can aggravate the condition.
What’s equally frustrating for women is that their hair loss is not as clearly understood as hair loss in men and, according to an article in www.dermentz.org, “..presents itself quite differently from the more recognizable male pattern baldness which usually begins with a receding frontal hairline that progresses to a bald patch on top of the head.” The same article also says that it’s uncommon for women to follow a male pattern unless there is excessive production of androgens in her body.
This moisturizing double-duty product is incredibly well rated (and you don’t even have to pay the pink tax to boot). Soy proteins and shea butter add silky strength, while scalp-tingling peppermint and rosemary provide minty freshness and lift at the root. “The thickening properties of the shampoo are great at this price point, so if you have thin or thinning hair, this will add some volume,” wrote one reviewer. “I also noticed that this is the first shampoo/conditioner shampoo that tends to actually condition your hair."
Late last week, HairClone officially unveiled its crowdfunding campaign with the Euro-based crowdfunding company Capital Cell. HairClone is offering equity based crowdfunding, which means anyone who makes an investment (£500 minimum) owns equity in the HairClone company. Full details on the campaign are listed in the latest HairClone article on the main page of Follicle Thought.
Besides cost considerations, a hair transplant is generally prescribed as a last resort for permanent hair loss problems. It is also not allowed for people under the age of 25, those with a continuing problem of hair loss, as well as those with other health conditions like uncontrolled diabetes, serious heart problems and hypertension. Patients whose hair loss is caused by other factors, such as a skin or scalp disorder or who suffer from a psychological condition that causes them to pull at their hair are not recommended for this procedure. Since the procedure requires taking a sample from the back of the head, those who do not have enough follicles from this section that can be used for transplant are not also eligible.
The patient, a small, vaguely European man in his late forties, had rings on his fingers and a bloody, rectangular gash on the back of his head. It looked like a chunk of missing carpet. Bernstein pointed at the white opening of exposed scalp, and explained how easy it would be to stitch skin together over the gap. This was a traditional process for follicular-unit transplantation. Then Bernstein led me into a second room, where another patient was seated with his face in a massage-table-like padded hole. A portion of the back of his head was marked off. To his right was a boxy gray machine, roughly four feet by four feet, with a jutting mechanical arm. This was the ARTAS Robotic Hair Transplant.
I recently published an article covering a story in the press of SkinTE helping to possibly save the life of a burn patient (see Articles). In that post I shared an image from SkinTE’s website which shows an application for hair growth. What some may not be aware of is the fact that Dr. Denver Lough, CEO of PolarityTE, has done some legitimate hair follicle research while at Johns Hopkins University. Whether or not this will increase the chances of a “HairTE” product to become a success, we can’t say. However, it may be of interest to recall two peer reviewed articles that Lough and colleagues published involving the proteins LGR5+ and LGR6+ stem cells and hair growth.
Now known as RCH-01, RepliCel’s procedure is a patented cellular replication and implantation technology designed to rejuvenate damaged and miniaturized hair follicles in a balding scalp. According to Buckler, the technology involves the extraction of as few as 20 hair follicles from the back of a patient’s scalp where healthy cycling hair follicles reside. Specific cells are isolated from hair follicles and are cultured using the company’s proprietary cellular replication process. The cultured cells are reintroduced or injected back into balding areas on a patient’s scalp and are expected to rejuvenate damaged hair follicles leading to the growth of new healthy hair fibers.
Each hair develops from a follicle — a narrow pocket in the skin — and goes through three phases of growth. Anagen (A), the active growth phase, lasts two to seven years. Catagen (), the transition phase, lasts about two weeks. During this phase, the hair shaft moves upward toward the skin's surface, and the dermal papilla (the structure that nourishes cells that give rise to hair) begins to separate from the follicle. Telogen (C), the resting phase, lasts around three months and culminates in the shedding of the hair shaft.
A very kind and talented hair blogger from Japan, Fuji Maru Kagurazaka, recently contacted me and suggested that the blogs aimed at promoting hair growth treatments/cures for hair loss should unite their efforts and cooperate. While I acknowledge that the websites who are focused on this material are each unique and have their own (and sometimes differing) perspectives, I do believe that civility and solidarity are certainly desirable qualities for this sector. Fuji wrote up this nice article about my website, check it out (make sure translate is on if you are not fluent in Japanese). And, I encourage you to read his other articles. Fuji has a sincere and highly detailed approach to hair growth blogging. His personality is highly welcomed and refreshing to the online hair community.
Your hair can suffer from many health-related factors. A diet that is lacking in vitamins and minerals lack proper hydration as well as damage from styling. Make sure you eat a varied and balanced diet with plenty of nutrient-rich foods including fruit and vegetables. Try and limit using heat to style. This includes hairdryers and straightening irons.
A clinician diagnoses female pattern hair loss by taking a medical history and examining the scalp. She or he will observe the pattern of hair loss, check for signs of inflammation or infection, and possibly order blood tests to investigate other possible causes of hair loss, including hyperthyroidism, hypothyroidism, and iron deficiency. Unless there are signs of excess androgen activity (such as menstrual irregularities, acne, and unwanted hair growth), a hormonal evaluation is usually unnecessary.
"Others are taking hair follicles out of human scalp and growing them with dermal papilla cells," Cotsarelis says. "If they grow in culture, you might be able to recombine them with skin cells and form new follicles. This would let you expand the number of follicles you get for a hair transplant. This may not be that far off -- five to 10 years, maybe. There's very good evidence you will be able to do that."
Anti-androgens. Androgens include testosterone and other "male" hormones, which can accelerate hair loss in women. Some women who don't respond to minoxidil may benefit from the addition of the anti-androgen drug spironolactone (Aldactone) for treatment of androgenic alopecia. This is especially true for women with polycystic ovary syndrome (PCOS) because they tend to make excess androgens. Doctors will usually prescribe spironolactone together with an oral contraceptive for women of reproductive age. (A woman taking one of these drugs should not become pregnant because they can cause genital abnormalities in a male fetus.) Possible side effects include weight gain, loss of libido, depression, and fatigue.
Giovanni Mele, a stylist who owns Giovanni and Pileggi in Center City, said many women with thinning hair try to wear their hair long. He thinks they're much better off with short, pixie-like styles with light layering on top. He recommends that lighter-skinned women choose colors that are a little darker than blond or gray. He is a fan of a hair-thickening product made by Nioxin.
Pura d’or makes a very bold claim with this product: “continued use WILL prevent further hair loss.” While we doubt it will “prevent further hair loss” for everyone, it does have an all-star line up of ingredients. Even if it doesn’t completely stop hair loss, this organic shampoo is certainly the safest for your hair out of our top 5. This shampoo is designed for daily use.
The Holy Grail remains a drug that will promote regrowth, but this might not be so far away. Earlier this year, Manchester University announced that an osteoporosis drug had been found to have “dramatic results” promoting hair growth when applied to tissue samples in pre-clinical trials. The resultant frenzy left the PhD student responsible, Dr Nathan Hawkshaw, a little dazed. “Every other week, something comes out about hair loss and it doesn’t generate as much media coverage as what I experienced,” he grumbles. He’s in this for the science – there aren’t many fields where you get to mess around with real human tissue – but such is the distress caused by hair loss and such is the potential customer base that interest is always high.
For those of you who only check the Updates page, there was a new Brotzu Check-In article published yesterday. Giovanni Brotzu will be presenting data pertaining to his lotion’s use in androgenetic alopecia at an Italian hair research Congress this Saturday, April 14th. We hope to see photo results from the presentation. Check back to the Brotzu article next week for updates.
Medical conditions and medications. A common medical condition that also causes hair loss is hypothyroidism, which can happen in both men and women. Patients suffer from an underactive thyroid gland, which is responsible for producing the hormone, thyroxin, which performs important bodily functions, such as the regulation of body temperature, proper utilization of carbohydrates and fats, and production of protein. Since protein is an important nutrient for the production of keratin, inadequate protein supply in the body due to an underactive thyroid means that hair growth in the follicles is slow. In men especially, hair loss is one of the first signs of hypothyroidism.
A separate study, published in Skin Therapy Letter — a professional reference site for dermatologists — found that women also benefit from using the more potent 5 percent minoxidil treatment. “Patient-reported improvement in hair volume and coverage appears to be greater with 5 percent minoxidil foam,” reads the report. Plus, because the 5 percent treatment is stronger, women only have to apply it once a day to get the same results as they would with the 2 percent treatment applied twice daily.
One is how much emphasis the company places on compliance, the major stumbling block in the efficacy of any treatment, said Dr. Senna, an author of studies on the subject. Prospective users are questioned about their ability to stick to a regimen because the extract must be applied every day, and they are told that the more conscientious they are, the better. Users are also reminded and encouraged with regular check-ins.