Follicle Thought is pleased to announce a new sponsor of this website, Hair Restoration Laboratories, LLC. The company produces quality anti-DHT shampoo and conditioner products. I have reviewed the ingredients of the shampoo and conditioner and find them to be very thoughtful and well researched. Also important to scalp health, the products contain no sulfates, no parabens, no silicones and no artificial ingredients. 

The Holy Grail remains a drug that will promote regrowth, but this might not be so far away. Earlier this year, Manchester University announced that an osteoporosis drug had been found to have “dramatic results” promoting hair growth when applied to tissue samples in pre-clinical trials. The resultant frenzy left the PhD student responsible, Dr Nathan Hawkshaw, a little dazed. “Every other week, something comes out about hair loss and it doesn’t generate as much media coverage as what I experienced,” he grumbles. He’s in this for the science – there aren’t many fields where you get to mess around with real human tissue – but such is the distress caused by hair loss and such is the potential customer base that interest is always high.


Hair growth company, Follicum of Sweden, announced today that their phase 2a trial for scalp hair growth has reached over 50% enrollment. The trial is scheduled to enroll 60 patients total who will receive injections of FOL-005, Follicum’s hair growth peptide. The study is designed to evaluate the hair growth response from different dosages of FOL-005.  Patients receive injections 3 times per week for 3 months total, for the duration of the study. The study is expected to be completed in 2018. Let’s hope Follicum finds some healthy and eager volunteers to round out their study pool asap.

Like the long-suffering friend who inspired her to undergo the procedure, Ms. Telford quickly saw an improvement in her hair. New hair growth usually take at least four months, but at the two-month mark, she has already spotted some baby hairs. “Not a gazillion,” she said, “but it’s a start.” She’s planning to return for follow-up treatments every six months, and has high hopes of ditching the wigs and wearing her hair in a pixie.
Not only does Nioxin promise that its system will deliver on denser-looking hair, it also includes a long list of ingredients that  inhibit the conversion of testosterone into DHT. These ingredients include nettle extract and saw palmetto. While Nioxin does include ingredients which studies have indicated help block DHT, the primary focus of Nioxin is to improve the cosmetic appearance of thinning hair.
The general medical consensus around laser treatments — caps and combs alike — is that low-level laser light therapy stimulates the cells within the hair follicle. These devices may also increase cell metabolism to promote thicker and more durable hair shafts, something that neither minoxidil or finasteride can do. To use the HairMax Ultima, all you have to do is glide the device over your scalp slowly. Treatments should take about eight minutes, and you should do it three days per week for the best results.

In II Kings 2:23-24, the prophet Elisha is mocked by a gang of surly kids. The kids “said unto him, ‘Go up, you bald head! Go up, you bald head!’ ” Elisha “cursed them in the name of the Lord.” Promptly “two she-bears came out of the wood and tore forty-two of them.” Sometime later—in 2013—German researchers published a study indicating that men experienced hair loss as an “enormous emotional burden” that could lead to an “impaired quality of life” and “psychological disorders.” Inversely, one study has shown that people perceive men with bountiful hair as likely having big penises.
Choose the right shampoo based on its healthy and all-natural active ingredients, such as those found in Veta. These products do work on your thinning and shedding hair. And if you’re wondering, “How fast will I regrow hair with a hair growth shampoo?” Well, that again depends on the cause of your hair loss: genetics, lifestyle choices, environmental triggers, etc... but also on the product’s composition and concentration of active ingredients. Veta has the highest concentrations of both follicusan and trichogen, which is why Veta products work.

Know the different types of wigs. Synthetic wigs are easy to style and are less expensive than human hair wigs. On the other hand, wigs made from human hair have a more natural look and feel, and are more preferred by those with permanent cases of hair loss. Though they take longer to style, human hair wigs are worth an investment if you plan on wearing it for a relatively long period of time.


After the new article featuring Medipost’s hair growth cosmetic was published, Jay Lee PhD of Medipost, began chiming in on the comments section. He first shared that Medipost is currently engaging in a larger clinical trial for the CM3 product which would include higher scale Norwood’s. Then, in a following comment he revealed that Medipost is developing a potentially more advanced hair growth product as well. Here are his words:
Dr. Carlos Wesley, a hair restoration surgeon in Manhattan, said that women in his practice respond better to P.R.P. than men do, which may have something to do with the fact that women with genetic hair loss tend to have more inflammatory cells around the follicles. From 2013 to 2014, he said, he had an 83 percent increase in female patients, in part because of P.R.P.

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The annual World Congress for Hair Research kicks off today in Kyoto, Japan. The Congress will go on until Friday November 3, 2017. The purpose of the event is to share presentations about different lines of research and product development regarding alopecia areata, stem cell biology, androgenic alopecia, cosmetic care, wigs, hair transplants, and more. Basically, all things hair industry. At these conferences a few companies typically will announce some news about their developments and progress. I’ll update any news I receive regarding announcements made at the Congress. WCHR2017 website.
Hair changes about as fast as grass grows, which is to say it’s extraordinarily slow and not visible to anyone checking impatiently in the mirror every day. But during regular follow-up appointments, Harklinikken uses high-tech equipment to photograph and magnify the scalp and count new hairs and active follicles, which motivates users to adhere to the regimen. Too many people give up on treatments like Rogaine and low-level-light devices before they’ve had a chance to work, Dr. Senna said.
In Michael Wolff’s “Fire and Fury,” Kuntzman’s theory is bolstered. Wolff writes that Ivanka Trump “often described the mechanics behind it to friends: an absolutely clean pate—a contained island after scalp-reduction ­surgery—surrounded by a furry circle of hair around the sides and front, from which all ends are drawn up to meet in the center and then swept back and secured by a stiffening spray.”
Literally jumping right out of the woodwork, the company “HCell” has announced they have been granted an orphan designation from the US FDA for their novel treatment of pediatric alopecia areata. The treatment itself it described as a “topical Injection by regenerating hair through a proprietary blend of commercially procured biologic and autologous tissue.” The company also mentions having a treatment for androgenic alopecia in the works as well. More info to come soon. News release here. 
Also, contrary to people's belief that 100 brush strokes a day can make your hair shiny and long, too much and too frequent brushing and combing can actually exert unnecessary pressure on the follicles, causing it to loosen its grip on the hair shaft, eventually resulting into hair fall. While regular combing is needed in order to encourage blood flow into the follicles, do so only when you need to style your hair, like in the morning. Use a wide-tooth comb as it allows for less tugging and pulling when you brush, especially when dealing with tangles. If tangles become unmanageable, use a moisturizing shampoo to loosen them.
In our research and our conversations with experts, one name kept popping up repeatedly: Rogaine. As the first topical brand FDA-approved to help regrow hair (all the way back in 1988), Rogaine benefits from more than 20 years of clinical trials and consumer feedback. Rogaine was the first brand to offer a 5 percent minoxidil foam solution when it debuted Men’s Rogaine Unscented Foam in 2006, and virtually every treatment developed since (for both men and women) has been an imitation or derivation of that formula. 

It has a very powerful mix of ingredients that addresses many of the known causes of hair loss. Revita contains emu oil and copper peptides, which help your hair follicles absorb the key nutrients in the shampoo. A revision to the product recently removed Ketoconazole, which eliminates dandruff by killing off the fungi that causes it. So if you’re looking for that particular ingredient this will no longer be a good option for you.
There’s no cure for baldness, but there are ways to hold on to what you've got. The six dermatologists and the clinical studies point to three methods: minoxidil, laser treatments, and prescription finasteride. The key is finding the combination and hair loss regimen that works for you. A doctor is your best bet for that kind of guidance — but we found a few trustworthy products that will work for most people.
Scientists from the Indiana University School of Medicine have for the first time created skin with hair follicles using mice stem cells. Research was led by Professor Karl Koehler. The team was able to grow both the epidermis and dermis layers of skin to create a realistic skin model. An interesting quote from Professor Koehler: “It looks like a little ball of pocket lint that floats around in the culture medium. The skin develops as a spherical cyst and then the hair follicles grow outward in all directions – like dandelion seeds.”
Avacor Physicians Formulation® for Men, Bosley Professional Strength Hair Regrowth Treatment for Men, Follinox-5 Hair Loss Treatment, Kirkland Minoxidil Extra Strength for Men 5% Topical Solution, Leminox for Men, Lipogaine for Men, Lipogaine for Men Sensitive, Men’s Rogaine Extra Strength, Nioxin Minoxidil 5% Hair Regrowth Treatment Extra Strength for Men, Perfect Hair 5% Minoxidil for Men, REDKEN Cerafil Retaliate 5% Hair Regrowth Treatment for Men
“Smelling” Receptor Keeps Hair Growing – Many of you may have noticed the headlines regarding sandalwood and hair growth over the past week. The research everyone is talking about comes from Ralf Paus and his team at the Monasterium Laboratory GmbH. For the record, Paus is also the main researcher behind the WAY-316606 hair growth discovery. This time Paus et al identified an olfactory receptor in hair follicles, OR2AT4,  which plays a role in regulating hair growth or inhibition. Olfacory receptors are responsible for detecting odors in cell membranes and provide the basis for our sense of smell, they do carry out additional functions though, as demonstrated by Paus. 

Due to the concern of several readers, I’ve removed the link to the new Trinov website that has popped up on the net. For now, the website only contains an email address subscription box which really poses no issue to anyone who subscribed. At this time, it’s not confirmed who the actual owner of the new Trinov site is, so use your discretion until we find out more regarding this matter. Until more information is known the website will not be shared on Follicle Thought.


Dealing and coping with hair loss is a particularly important issue, especially for those who lost (or continue to lose) their hair because of cancer and other chronic conditions that require chemotherapy or radiation therapy. It can be a particularly trying time, and there are instances when the depression settles in that the patient is unable to even consider or think about hair loss options and cures.
More good research coming from the University of Alabama at Birmingham shows that a certain gene affecting mitochondrial function can dramatically reverse signs of aging in mice. The aging factors which were shown to be reversible include skin wrinkles, gray hair, and hair loss. Next comes the important phase where the researchers continue forward to translate this discovery to human use. Full article on the front page.
Male patten baldness affects about 20% of men by the time they’re 20 and rises roughly in line with age: about 30% of men will experience significant hair loss by 30, 40% of men by 40, half of men aged 50, and so on. If you’ve retained your hair by middle-age, you’re one of the lucky ones. I’m elated to say that I’m well thatched at 37, but the grey specks in my beard bother me enough to know that if I did lose my hair, I’d be dismayed. For some reason, there is something inherently conical, sorry comical, about baldness; some people can deal with that and indeed, emerge stronger and surer of themselves. It’s fair to say Jason Statham wouldn’t have been a match for a prehistoric shark with his 1995 hair. But for others it’s just not so easy.
Iron supplements. Iron deficiency could be a cause of hair loss in some women . Your doctor may test your blood iron level, particularly if you're a vegetarian, have a history of anemia, or have heavy menstrual bleeding. If you do have iron deficiency, you will need to take a supplement and it may stop your hair loss. However, if your iron level is normal, taking extra iron will only cause side effects, such as stomach upset and constipation.
Take in natural supplements. If you aren't getting enough nutrients from the foods you eat, you can also try taking natural supplements to address your nutritional deficiencies. Multivitamins that especially contain vitamins A, C, and the B-complex vitamins can be taken once a day. Fish oil capsules that contain omega-3 fatty acids are also recommended.
A clinician diagnoses female pattern hair loss by taking a medical history and examining the scalp. She or he will observe the pattern of hair loss, check for signs of inflammation or infection, and possibly order blood tests to investigate other possible causes of hair loss, including hyperthyroidism, hypothyroidism, and iron deficiency. Unless there are signs of excess androgen activity (such as menstrual irregularities, acne, and unwanted hair growth), a hormonal evaluation is usually unnecessary.
Sadick suggests avoiding “products with dyes and preservatives, like parabens and synthetic fragrances.” Ingredients that thicken the hair include amino acids, biotin, ginseng root, and menthol or peppermint oil — these are what you want to look for. “Amino acids provide the building blocks to build new strands, while biotin, part of the B-vitamin complex, is required by hair to metabolize amino acids and can help strengthen hair,” Sadick says. “Antioxidants such as vitamin E and ginseng are beneficial to promote hair growth because they reduce free radicals from sun, stress, or overprocessing and have anti-inflammatory properties.” Last but not least are the botanicals, which are great as they are rich in antioxidants and other compounds that stimulate blood flow and promote hair growth.
The cause of female-pattern hair loss is unknown, but doctors said there is a strong genetic component. The risk can come from male or female relatives. Though it looks as if the hair is falling out, that's not really what's happening. Cotsarelis said hair follicles are becoming smaller and producing hairs that may be so small that you can't see them.  Women tend to retain more normal, thick hairs than balding men do.

Hair transplantation involves harvesting follicles from the back of the head that are DHT resistant and transplanting them to bald areas. A surgeon will remove minuscule plugs of skin that contain a few hairs and implant the plugs where the follicles are inactive. Around 15 percent of hairs emerge from the follicle as a single hair, and 15 percent grow in groups of four or five hairs.


Dr. Hawkshaw and his team were lead to test WAY-316606 for hair growth after studying the effects of cyclosporine A (CsA) on hair growth. They found that CsA reduced the expression of SFRP1 in human hair follicles. After looking for other drug candidates that had a similar effect on SFRP1, WAY-316606 was identified. The team has already tested WAY-316606 on isolated human hair follicles which were donated from hair transplant surgeries, and plans to test the drug in human clinical trials in the future. A timeline for a human clinical trial has not been set yet, Follicle Thought will update this as news is presented.
Buckler said it started in 2003 with the academic research of Hoffmann and McElwee at the University of Marburg in Marburg, Germany. At the time they were trying to understand what was happening in the hair follicles of people suffering from androgenetic alopecia—a common form of hair loss in both men and women—or the underlying cause of hair loss.
I have only used this twice, but in that short time of use, I believe my hair shedding has increased. In fact, immediately following the last use my hair seemed to be coming out more than I had seen prior to ordering the shampoo at all. Experiencing hair loss, thinning, or excessive shedding (especially for a woman) can be very distressing, and to purchase a product in hopes that it will help to curb or even reverse the issue only to find it exacerbates the problem is INCREDIBLY stressful. I was hopeful about this product, given the overall reviews, but I'm afraid to use this product even one more time, for fear of making my hair loss worse.

If you're dealing with premature hair loss, you know how frustrating it can be to treat. What can be equally as frustrating is trying to find hair products that will actually help remedy thinning or breaking locks. To help you navigate the confusing world of hair loss, I reached out to Manhattan-based dermatologist Dr. Joshua Zeichner and used his recommendations to find the best shampoo and conditioner for hair loss.
Thanks so much for the guidance! After further research I have to agree with you 100%. Lipogaine Big 3 does containe ketoconazole, which would eliminate the need for Nizoral, however the shampoo only contains a few hair loss/thinning related ingredients. The Big 5 contains 17 and just seems like a better overall product. That plus Nizoral twice weekly seems pretty solid to me.
Our runner-up Clinical Effects Hair Therapy was a very close second to our top pick and our Best Value choice. Several of our testers felt that this was the overall best shampoo both in how their hair felt as well as the light scent.  We feel that it is the best overall value in this category as you can buy it at a price significantly less than the competition.  Clinical Effects is for both men and women and comes with an amazing 90 Day guarantee that is also the best in this category. We highly recommend it if you’re looking for a less expensive option to Shapiro MD.  They have fantastic customer service and stand behind all of their products.

While there are much worse things that can happen to a person than losing their hair, there’s also no denying how incredibly frustrating it can be. There are many reasons for hair loss, including genetics, and even more products and solutions out there which claim to slow its progress while even growing new hair. Finding one that works for you, however, can be easier said than done. But we’re here to help.
Coming to terms with hair loss can be the source of a lot of unwanted stress and frustration. After all, we're quite attached to our hair. Even though a lot of men pull off the bald look extremely well, saying goodbye to a thick head of hair is difficult. But what if I told you that experiencing hair loss doesn't mean that you have to go bald? In fact, with the right treatment program, you might be able to stop the dreaded receding hairline.

Try balayam yoga. Balayam yoga (also called balam yoga) is an ancient acupressure exercise associated with hair growth. It comes from the Hindu words, Bal, which means hair, and Vyayam meaning exercise. The exercise involves rubbing the fingernails on both hands together to stimulate activity in the scalp. It has been known to help cure pattern baldness in men and women if done correctly and frequently over a long period of time.
Thanks so much for the guidance! After further research I have to agree with you 100%. Lipogaine Big 3 does containe ketoconazole, which would eliminate the need for Nizoral, however the shampoo only contains a few hair loss/thinning related ingredients. The Big 5 contains 17 and just seems like a better overall product. That plus Nizoral twice weekly seems pretty solid to me.
There have also been studies on the effects of 1% pyrithione zinc shampoo and a 5% minoxidil solution. In one study, 200 men between the ages of 18 to 49 who experienced baldness between type III and type IV on the Norwood scale were given this treatment for a six-month period. They found that minoxidil, when used on its own, was approximately twice as powerful as pyrithione zinc at stimulating hair growth, but that both products were successful at increasing the amount of visible hair when used over a 26-week period.

Hair multiplication. Similar to the idea of cloning, this treatment involves taking out donor cells from the hair follicles and then growing and multiplying them in a laboratory. Once sufficient samples have been multiplied, these hair cells are then injected into the bald patches to stimulate hair growth. As a relatively new treatment, hair cloning is still in its research phase.

Some 30 million women in the United States have hereditary hair loss (compared with 50 million men), according to the American Academy of Dermatology, though that figure does not include the millions more who struggle with thinning hair because of pregnancy, menopause, stress and other health conditions. Barely 5 percent of women are said to be good candidates for hair transplant surgery because women lose hair everywhere, meaning that, unlike with men, there is rarely a luxuriant spot on the back of the head from which to harvest hairs unobtrusively.


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2. Volumizing shampoos and treatments. Typically, these work by depositing ingredients, like wheat protein and keratin, that adhere to the hair shaft to a) thicken it and b) create spaces between hairs so you look like you have more of it. Try Kiehl’s Rice & Wheat Volumizing Shampoo ($18) with hydrolyzed wheat protein; Rogers likes Redken Cerafill Defy Shampoo and Conditioner ($20 each) with ceramides that bulk up hair.
2. Pyrithione zinc shampoo. Traditional volumizing shampoos will give the hair you have a lift so it looks fuller (we like the sulfate-free L’Oréal Paris EverPure Volume Shampoo, $8). But some research suggests shampoos with the antidandruff ingredient zinc pyrithione can mitigate hair loss that’s caused by conditions like dandruff, says Mirmirani. Try Head & Shoulders Deep Moisture Shampoo ($6), and use a conditioner without silicones — they can make hair appear limper, especially if it's applied near the roots (we like Love Beauty and Planet Coconut Water & Mimosa Flower Conditioner, $9).
Each follicle produces hair for 2 to 6 years and then takes a break for several months. While the hair follicle is in its rest phase, the hair falls out. There are around 100,000 follicles on the scalp, but because each follicle rests at a different time and others produce hairs, hair loss is usually unnoticeable. More noticeable hair loss occurs when there is a disruption to the growth and shedding cycle, or if the hair follicle is obliterated and replaced with scar tissue.
Know the different types of wigs. Synthetic wigs are easy to style and are less expensive than human hair wigs. On the other hand, wigs made from human hair have a more natural look and feel, and are more preferred by those with permanent cases of hair loss. Though they take longer to style, human hair wigs are worth an investment if you plan on wearing it for a relatively long period of time.
"Firstly, even the very good ones won’t get to the root of the issue - pardon the pun - and prevent or treat male or female pattern baldness which is caused by genetics, nor deal with hormonal issues at the heart of female hair loss. But they can help make the hair you do have stronger and healthier. And they can be useful in putting a hair loss regime in place, along with medication like Minoxidil or Finasteride and/ or a hair transplant.
Aside from medication and lasers, some opt for hair transplants — a procedure where hairs are removed from another part of your body and then transplanted to the thinning or balding areas. Does it work? In a word, yes. Research suggests that most hair transplant recipients report are "very satisfied" with their results. While successful, transplants are also far more expensive than medications, foams, or lasers with costs averaging anywhere from $4,000 or $15,000.

Would there be any harm/benefit in combining the use of two hair-loss prevention shampoos, to take advantage of different ingredients and functions? Mainly Nizoral, at the twice a week recommendation, plus the Argan Oil Shampoo twice a week? I have somewhat oily hair and do get dandruff from time to time, but I do feel after washing my hair, it can feel dry and stiff. Just wondering if a combination of the two (one for dandruff, and one for healthy, thicker hair) might prove effective. Also, would you have any recommendations on a combo? Thanks!
The dermatologist also will carefully look at your scalp and hair. During an exam, the dermatologist may pull on your hair. Sometimes a dermatologist needs to pull out a hair to get the necessary evidence. And sometimes a dermatologist needs to look at the hair on the rest of your body to see whether there is too little or too much hair in other areas.

McElwee is an associate professor in the Department of Dermatology and Skin Health at the University of British Columbia (UBC) in British Columbia, Canada and director of the Hair Research Laboratory in the Vancouver Coastal Health Research Institute (VCHI) at Vancouver General Hospital (VGH). A hair research scientist, McElwee is one of only a small group of research scientists worldwide who studies hair biology and associated diseases.
Since PhytoCayne Revitalizing shampoo is so watery, it’s easy to overpour and waste a good amount of this expensive product. That’s one reason we rank it below Revivogen and Nioxin. The more important reason for the #3 ranking is that this shampoo doesn’t do everything that the other two products do. It’s still effective for most users, however, and worth a try.

Lipogaine Big 3 does contain ketoconazole, but only a couple other hair loss/thinning related ingredients. Their Big 5 does not contain ketoconazole, but it does contain a proprietary mix of 17 ingredients for hair loss/thinning. It seems to be a more complete shampoo overall, aside from the hair loss aspects. My initial thought is to go with a combination of Big 5 and Nizoral.


Thinning hair in women is worth investigating for more than its impact on physical appearance. While many conditions that lead to temporary hair loss will go away without treatment or with simple lifestyle measures, others may be signs of potentially irreversible loss or health conditions. Others yet may respond well to treatments to promote regrowth, so starting sooner rather than later is key.
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