Alexey Terskikh PhD of Sanford Burnham Prebys research institute has news to share about his hair follicle research. The Articles page gives you all the highlights on what advancements Terskikh has made over the past three years and when he is planning to take his cloning method to FDA human trials. This is one example of a peer reviewed journal article which actually developed to human translation in a timely manner. Happy Friday

There’s a lot of misinformation, half-truths, and pseudoscience regarding hair loss, and there are also treatment programs that have been well-researched and tested in clinical settings. So, how do you find the difference? For starters, talk to the experts in the industry like dermatologists and general physicians about treatment programs. Avoid people advertising secret cures, all-natural remedies, and permanent fixes. If there was a way to stop baldness from happening, we’d all know about it already.
The method for applying hair loss shampoo is the same as regular shampoo, i.e., you apply it to wet hair, massage it into the scalp and rinse it. The difference with hair-loss shampoos, however, is that you should leave them in for a longer time before rinsing. Doing so ensures that their ingredients reach your hair’s roots and scalp, where they have the biggest impact.
I hope you’re all having a good Friday and feeling good out there. Two weeks ago I posted my first “Feel Good Friday” update which contained a hilarious video of Deion Sanders showing off his new hairline from a 5,000+ FUE procedure he had in 2017. That video is now unable to embed because its owner changed his account to private. Coincidentally, a week after I shared that video I noticed that Deion posted a new video to his own Instagram account of him going back to his clinic for another FUE hair transplant to “comeplete his comeback”, in his own words.
While the drug is generally safe for use, some possible side effects are mild irritation of the scalp, dryness and growth of hair on some parts of the body, especially the sides of the face and hands. In some cases, you might observe some increased hair loss around the first few days of use. If the hair fall continues after two weeks upon application of minoxidil, stop the treatment first and see a doctor.

*Photograph used with permission of the Journal of the American Academy of Dermatology. This photograph was published in the Journal of the American Academy of Dermatology, Vol. # 60, Gathers RC, Jankowski M, Eide M, et al. “Hair grooming practices and central centrifugal cicatricial alopecia,” 660-8. Copyright Elsevier (2009). Journal of the American Academy of Dermatology.   
Hair transplantation involves harvesting follicles from the back of the head that are DHT resistant and transplanting them to bald areas. A surgeon will remove minuscule plugs of skin that contain a few hairs and implant the plugs where the follicles are inactive. Around 15 percent of hairs emerge from the follicle as a single hair, and 15 percent grow in groups of four or five hairs.
Nizoral is the gold-standard in hair loss prevention. Its main ingredient is ketoconazole. The nice thing about Nizoral is that you only need to use it twice a week (because ketoconazole binds to the proteins in your hair so it will keep working many days after use). If you were to use it daily your scalp would be drier than a desert and itchy as all heck.
2. Pyrithione zinc shampoo. Traditional volumizing shampoos will give the hair you have a lift so it looks fuller (we like the sulfate-free L’Oréal Paris EverPure Volume Shampoo, $8). But some research suggests shampoos with the antidandruff ingredient zinc pyrithione can mitigate hair loss that’s caused by conditions like dandruff, says Mirmirani. Try Head & Shoulders Deep Moisture Shampoo ($6), and use a conditioner without silicones — they can make hair appear limper, especially if it's applied near the roots (we like Love Beauty and Planet Coconut Water & Mimosa Flower Conditioner, $9).
It’s also possible that some of Harklinikken’s users are women whose hair would have grown back even if they’d done nothing. Many women who arrive in a dermatologist’s office with prior diagnoses of female pattern hair loss actually have what’s called telogen effluvium. That’s a period of acute shedding of hair — meaning up to 60 percent of hair — three months after a triggering event like pregnancy, significant weight loss or starting or stopping hormone medications.
It can be safe provided you use registered, regulated healthcare or pharmaceutical services. LloydsPharmacy Online Doctor offers both Propecia and finasteride for men suffering from male pattern baldness through a safe and discreet online prescription service, and you will be able to order minoxidil or Regaine through our online shop or in one of our pharmacy stores.
That meant new products like Hims and Keeps were out.Hims and Keeps are relatively new companies that allow you to set up a subscription for hair loss treatments. Both offer finasteride (after an online consultation with a doctor) or 5 percent minoxidil. However, their minoxidil solutions contain propylene glycol, so we cut them from consideration.
I started combining two of them right away – because they both had different ingredients that I really wanted. I combine the Hair Surge for the caffeine, ketoconazole, and saw palmetto, along with the Regenepure DR for the Emu oil. I use a bit of both every day – and though I haven’t noticed a lot of hair coming back in – I HAVE noticed that a whole lot less is falling out. I used to see lots of hair in the tub or in my hand after drying. Hopefully some baby hairs will start so show themselves soon.

Beyond that, things get more controversial, with some doctors saying there's inadequate evidence for other treatments. Saxena thinks there is enough scientific evidence to support some of the alternatives and recommends them to patients. But they are not for women on tight budgets. There's Nutrafol, a "nutraceutical" that costs about $80 a month. Women can also get injections in the scalp of platelet-rich plasma made from their own blood. The first four treatments cost about $2,000 at Saxena's practice in Fort Washington or Lansdale. Maintenance injections, done every three to six months, cost $515 each. Women can also buy Theradome, a light-emitting helmet, for $895 online.  Saxena, who has hair loss herself, said she has had the injections and currently uses minoxidil, spironolactone, and Nutrafol.


NTU Working To Prevent Chemo-Induced Loss – Researchers from the National Taiwan University have developed a model for preventing chemotherapy induced hair loss, according to their publication in Cancer Research journal. The team, lead by professor Lin Sung-jan, identified a specific type of cell that hair follicles utilize to compensate for the toxicity which occurs during exposure to ionizing radiation (chemotherapy). These cells are called transit-amplifying cells (TAC). Preclinical animal testing with applied TAC-derived progenitor cells showed a 70-80% reduction in hair loss after chemotherapy and radiotherapy. Importantly, Sung-jan has recently stated he is in talks with companies about conducting trials on humans. It’s interesting to note that Lin Sung-jan has done an extensive amount of research on hair regeneration in the past. Hopefully this treatment could potentially be used for more common types of hair loss as well.


After a severe illness, I lost more than half of my formerly beautiful long hair. Since then, I've tried many shampoos claiming to encourage regrowth of healthy hair. Well, I found it! This shampoo really works. It smells great and has resulted in my hair being stronger and shiny; it no longer breaks easily and my hair stays on my head rather than in the hairbrush! Yay! Be sure to follow the instructions for use. A little goes a long way.

The most popular low-light laser therapy product is developed by Hairmax. They have a series of Hairmax Laser Combs. Treatment is applied weekly or more frequently. Notably, the Hairmax Laser Comb was the 3rd product to receive FDA approval for treatment of genetic balding. It followed Minoxidil and Finasteride. Though some scalps are very responsive to this laser treatment, others seem to only reap the benefit of slowing hair loss. Another downside is that each treatment session takes about 15 minutes, where the laser comb must be directed towards thinning and bald areas. Unless you have a handy device such as the one in the image, you stuck doing things manually. 

Rub the gel-like sap/juice of the aloe vera leaf directly on your scalp. Leave it on for a few hours and then rinse with lukewarm water. Do this three to four times a week. You can also mix a tablespoon of aloe vera gel with wheat grass juice to boost hair growth. Wheatgrass is also rich in protein, vitamins C and E and other minerals. Drink the wheatgrass juice mixed with aloe vera extract for two weeks to stop hair breakage and minimize hair fall.
Our panel of five people was unanimous in their choice – Shapiro MD. Developed by two leading dermatologists this patented formula has been proven to fight and even reverses hair loss in both men and women.  While some testers found the smell a bit herbal the overall consensus was that it was a fantastic color-safe shampoo and a moisturizing conditioner. In addition, we found their customer service was excellent and they honored their 60-day guarantee.  Shapiro MD designed their shampoo and conditioner with pharmaceutical-grade ingredients.  Shapiro MD’s mission is to develop health and beauty products using only clinically tested ingredients.
The HairMax Ultima 12 LaserComb ($395) makes for a great addition to any hair loss regimen — provided you can afford it. Dr. Wolfeld notes that it’s a popular option in his practice. “Some people like the action of combing something through their hair,” he says. “They find that to be a little bit easier to do as part of their routine in the morning.” Dr. Khadavi also recommends using a laser treatment of some kind in conjunction with other treatments. “Lasers do help in stimulating the hair into the growth phase. We don’t know the exact mechanism of how it works, but it definitely helps.”
When it comes to organic products there are popular and high-quality brands you can choose from. Some chemicals can have quite harsh effects on longer hair, which means that they are not always suitable for women.  There are several organic brands that can be effective for those sensitive to these chemicals and in some cases can be more effective. Among the organic shampoos available are Reborn MAX and PhytoWorx.  Two brands that use caffeine are Apex Crown from Wick & Strom, and Ultrax Labs Hair Surge.
If you think over-the-counter hair loss shampoos are for you or just want to promote growth and strength, Dr. Schwieger recommends formulas with antioxidants such as vitamin E and ginseng, amino acids, and B-vitamins to help rebuild hair and reduce environmental damage. She cautions against those with parabens, sulfates, and fragrances, which can irritate hair and reduce moisture. Ahead, eight vetted hair loss shampoos to try.
This is a bestselling shampoo on Amazon. The list of ingredients is extremely lengthy. The product contain a number of natural organic DHT blockers (including saw palmetto) and various nourishing hair vitamins. Additional beneficial ingredients include amla oil, argan oil, pumpkin seed oil, rosemary oil, tea tree oil, green tea extract, niacin and biotin.
The general medical consensus around laser treatments — caps and combs alike — is that low-level laser light therapy stimulates the cells within the hair follicle. These devices may also increase cell metabolism to promote thicker and more durable hair shafts, something that neither minoxidil or finasteride can do. To use the HairMax Ultima, all you have to do is glide the device over your scalp slowly. Treatments should take about eight minutes, and you should do it three days per week for the best results.
Hair growth is a giant industry, with estimated annual sales of $3.6 billion. And every one of those dollars goes to products that do not provide actual hair regeneration. Rogaine and Propecia, the market leaders, can slow hair loss, but they don’t grow new hair. They also come with the small risk of serious side effects. In 2011, Men’s Health reported on a Propecia user who “lost all pleasurable sensations in his penis.”
Keranique Hair Regrowth 3-Piece Treatment Set for Women, Lipogaine for Women, Pantene Minoxidil 2% Hair Regrowth Treatment for Women, Prominox 1 Hair Loss Shampoo, Prominox 2 Hair Loss Conditioner, Prominox 3 Hair Growth Stimulator, Prominox 6 Leave-In Hair Loss Conditioner, REDKEN Cerafil Retaliate 2% Hair Regrowth Treatment for Women, Rogaine for Women Hair Regrowth Treatment
Keranique Hair Regrowth 3-Piece Treatment Set for Women, Lipogaine for Women, Pantene Minoxidil 2% Hair Regrowth Treatment for Women, Prominox 1 Hair Loss Shampoo, Prominox 2 Hair Loss Conditioner, Prominox 3 Hair Growth Stimulator, Prominox 6 Leave-In Hair Loss Conditioner, REDKEN Cerafil Retaliate 2% Hair Regrowth Treatment for Women, Rogaine for Women Hair Regrowth Treatment
In-office laser light treatments or at-home handheld devices, such as the HairMax LaserComb, supposedly grow new hair by stimulating blood flow to the area (think: an amped-up version of a scalp-stimulating shampoo). Just don’t expect the device to make your noggin go from looking like George Costanza’s to Jerry Seinfeld’s. “These lasers won’t grow any new hair. If anything, they may just help you hang on to some of the hair that you already have a bit longer,” says Dr. Joyce.
Coconut milk / coconut oil. Coconut milk/oil, like aloe vera, is one of the oldest and most common natural ingredients for promoting hair growth and growing healthy, shiny hair. Coconut is rich in protein, iron and other minerals that promote healthy hair and prevent breakage. Apply the coconut milk/oil on your bald spots or all over the scalp, and leave it on overnight. Rinse the next day with cool water. You can do this every time you wash your hair.
This is an organic shampoo which contains the key ingredient Biotin, often said to topically strengthen existing hair strands. Pura d’Or shampoo also has a proprietary ingredient based on Saw Palmetto, which supposedly blocks DHT – the key culprit in pattern baldness. Some users say it hasn’t just protected their existing hair but has promoted the growth of healthy new hair as well.
Best hair loss treatment shampoo for women and men is made with natural, herbal ingredients that promote a healthy scalp and hair follicles. We use no sulfates, no parabens and no harmful ingredients. Our formula is safe for color treated hair as well as processed and natural hair. We avoided using any additives instead opting for ingredients found in nature so our hair is safe for all hair types and textures, no matter your age. Our dandruff and hair loss prevention shampoo goes to the root of the issue repairing the scalp instead of just covering the symptoms.
There’s no cure for baldness, but there are ways to hold on to what you've got. The six dermatologists and the clinical studies point to three methods: minoxidil, laser treatments, and prescription finasteride. The key is finding the combination and hair loss regimen that works for you. A doctor is your best bet for that kind of guidance — but we found a few trustworthy products that will work for most people.
I am so happy with this product. I have thinning hair and have used many products in the past trying to at least stop it. I don't expect a miracle for it to grow back but I would love to just stop the hair falling out. Immediately after using this just one day I already noticed improvements. I was told my hair shined more, it was softer and also fuller. The hair falling out has improved a lot. I have not personally noticed hair growth yet but its only been 2 weeks now and I can say without a doubt it has made my hair healthier. I will be getting more for sure
Hair grooming, but more importantly, having a head-full of hair is as important to men as it is to women. To women, it may be an important accessory of beauty, and for men, it adds to a sense of manliness, enhances their looks and makes them more appealing and attractive to women. Balding to men is associated with aging (only old men are expected to lose hair) and therefore, having hair on one's head is a sign of virility and masculinity.
Other therapies for the treatment of alopecia areata include topical mid- to high-potency corticosteroids, minoxidil, anthralin, immunotherapy (diphenylcyclopropenone, squaric acid dibutylester), and systemic corticosteroids.12 Currently available therapies often yield unsatisfactory results, and some clinicians rely on the high rate of spontaneous remission or recommend a hairpiece or wig if remission does not occur.13
But in November, after 10 years of research, Rogaine introduced a new 5 percent minoxidil formulation for women. It’s a mousse (instead of a liquid) that needs to be applied only once a day instead of twice, which means that it can be more easily incorporated into a woman’s evening skin-care routine. Teal replaces the blue and silver palette of the men’s Rogaine, and the packaging bears a lotus flower. (Also last year, Pantene introduced its Hair Regrowth Treatment for Women, which is 2 percent minoxidil.)
Central centrifugal cicatricial (scarring) alopecia: This type of hair loss occurs most often in women of African descent. It begins in the center of the scalp. As it progresses, the hair loss radiates out from the center of the scalp. The affected scalp becomes smooth and shiny. The hair loss can be very slow or rapid. When hair loss occurs quickly, the person may have tingling, burning, pain, or itching on the scalp. Treatment may help the hair re-grow if scarring has not occurred.
There have also been studies on the effects of 1% pyrithione zinc shampoo and a 5% minoxidil solution. In one study, 200 men between the ages of 18 to 49 who experienced baldness between type III and type IV on the Norwood scale were given this treatment for a six-month period. They found that minoxidil, when used on its own, was approximately twice as powerful as pyrithione zinc at stimulating hair growth, but that both products were successful at increasing the amount of visible hair when used over a 26-week period.
Finasteride inhibits an enzyme that converts testosterone to DHT, or dihydrotestosterone, the hormone that causes hair loss in men, and unlike minoxidil, this drug can actually help hair grow back, as well as prevent further loss. All you have to do is take one pill a day, and according to Dr. Evan Rieder, dermatologist in the Ronald O. Perelman Department of Dermatology at NYU Langone Health, two-thirds of men taking this treatment will see improvements in hair density over time. 

Dr. Carlos Wesley, a hair restoration surgeon in Manhattan, said that women in his practice respond better to P.R.P. than men do, which may have something to do with the fact that women with genetic hair loss tend to have more inflammatory cells around the follicles. From 2013 to 2014, he said, he had an 83 percent increase in female patients, in part because of P.R.P.
Women with androgenic alopecia may consider trying prescription ketoconazole at a strength of 2 percent. This drug comes in the form of a shampoo and also goes by the name Nizoral. It’s an antifungal agent and may help reduce the body’s production of testosterone and other androgens that lead to hair loss. You can also find 1 percent strength at your local pharmacy, but it may not be as effective.
McElwee is an associate professor in the Department of Dermatology and Skin Health at the University of British Columbia (UBC) in British Columbia, Canada and director of the Hair Research Laboratory in the Vancouver Coastal Health Research Institute (VCHI) at Vancouver General Hospital (VGH). A hair research scientist, McElwee is one of only a small group of research scientists worldwide who studies hair biology and associated diseases.
Beware online stores selling Propecia without a prescription.Finasteride is FDA approved, but buying it online without a prescription can be illegal and dangerous. Prescription-free online stores have a reputation for selling placebos or dangerous replacements. We recommend speaking with a doctor about prescriptions or sticking to save over-the-counter treatments.
Laser treatments. Low-level laser therapy (LLLT) is used for the prevention and reversal of hair loss. Also known as red light therapy, cold laser, and soft laser, it is a form of light/heat treatment (therefore generally safer) that is used on cases of pattern baldness and alopecia areata. The procedure uses a device that emits light that penetrates into the scalp. The more commonly used lasers are the excimer, helium-neon and fractional erbium-glass. The procedure can increase the blood flow in the scalp to stimulate the follicles that are in resting or dormant phase to go into anagen, and at the same time, prevent the production of DHT, which destroys the hair follicles.
But in November, after 10 years of research, Rogaine introduced a new 5 percent minoxidil formulation for women. It’s a mousse (instead of a liquid) that needs to be applied only once a day instead of twice, which means that it can be more easily incorporated into a woman’s evening skin-care routine. Teal replaces the blue and silver palette of the men’s Rogaine, and the packaging bears a lotus flower. (Also last year, Pantene introduced its Hair Regrowth Treatment for Women, which is 2 percent minoxidil.)
Things get interesting when we discover a patent which was filed by Sangamo in May 2017 titled “Targeted Treatment of Androgenic Alopecia.” As with virtually all patents, the lengthy text of the patent is difficult to read or to create a concise summary from. An intriguing aspect of this news is Sangamo works in several technology spaces, including previously mentioned genome editing and gene therapy, either would make an advanced type of hair growth therapy we have never seen before. One caveat to mention is the company’s pipeline does not currently display any indication for alopecia, meaning the therapy is not fully developed yet, so it will be some time before trials begin. We certainly hope to hear more from Sangamo Therapeutics as soon as possible about their interesting development for hair growth technology.
3. Hair fibers. The best (and easiest) way to hide a widening part or sparse patch is with hair fibers. They’re tiny, charged fibers that adhere to your scalp (until your next shampoo). Toppik Hair Building Fibers ($25) come in a range of colors so you can easily find one that matches your own hair. (In a pinch, you can also brush a powdered eye shadow that matches your hair color along your part.)
Disruptions in the normal length of each phase, which can cause hair loss and hair thinning, may be the result of a number of internal and external stimuli. These are also what we call the triggers and causes of your hair loss. As a quick example, dieting can leave the body stressed and in need of important nutrients. Because of this stress, hair growth may be cut shorter than usual and there is an early onset of telogen or shedding of hair.
Away from Silicon Valley, though, a clutch of companies are competing to provide the true cure. There are a few primary approaches. The San Diego company Histogen has been around since 2007, making it a veteran in this inchoate field. Histogen is working toward “an injectable for hair growth,” its founder, Dr. Gail Naughton, told me. What Histogen wants to inject in you are extracts from “neonatal cells grown under simulated embryonic conditions.” Histogen is convinced that these cells stimulate “growth factors” that signal hair formation. That’s option No. 1: first, a cell solution is whipped into a hair-growing frenzy, in a lab; then it’s punched into your head. “Some people would rather take a pill,” Naughton acknowledged. “But we have some nice benchmarks, with something like Botox. You’ll be able to have a physician come to a Tupperware party” and give the injections. The market, Naughton knows, will be huge. “It’s not just hair,” she said. “Anything in aesthetics has been booming worldwide. Anything to be more youthful-looking, anything to regenerate yourself. Anything to live longer.”
3. Hair fibers. The best (and easiest) way to hide a widening part or sparse patch is with hair fibers. They’re tiny, charged fibers that adhere to your scalp (until your next shampoo). Toppik Hair Building Fibers ($25) come in a range of colors so you can easily find one that matches your own hair. (In a pinch, you can also brush a powdered eye shadow that matches your hair color along your part.)

While some medical practitioners are still on the fence about the effectiveness of laser treatments, studies have found that hair growth using laser therapy increased by 19 normal-size hairs per square centimetre. The regrowth is also observed as thicker, shinier and more manageable. It's a non-invasive, painless procedure that works for both men and women. However, the LLLT is not a stand-alone cure and is thus used in combination with other treatments.
One friend who went bald in his early 20s said that even once he’d readjusted to his new look, the thing that saddened him was that this look would define him pretty much for ever. Another, now in his 40s, found it dispiriting when his hair started falling out in his 20s – “the first sign that my youth was fading…” He decided against Minoxidil and Finasteride – “If I recall correctly, one of the side effects was impotence or diminished libido, which didn’t seem a good trade-off” – and found the idea of surgery “laughable”, so opted to shave it all off, finding some cheer in the new-found solidarity among his fellow balding friends. Still, he says, anti-bald prejudices are real.
What’s got less evidence supporting its efficacy are the hair-growth shampoos that claim to block DHT (like those sold by Hims in their Rx Hair Kit). Rieder is skeptical that you’re going to see any tangible benefits by rubbing DHT blockers into your scalp. “I find it very difficult to believe that something that’s applied to the scalp and rinsed off is going to have any appreciable effect.” All four doctors also shut down any suggestions that hair-growth supplements or vitamins, like biotin, could help promote hair growth or stop hair loss — though a couple hypothesized that vitamins or supplements could lead to hair regrowth if your hair loss was a result of a nutritional deficiency. But otherwise, if you’re dealing with regular old male-pattern baldness, “There is no such thing as a ‘hair vitamin,’” says McMichael.

“We are extremely pleased with the continued development of the patent portfolio we exclusively licensed from Columbia.  This new issuance continues to expand the breadth and depth of our JAK inhibitor intellectual property portfolio covering methods of use for certain JAK inhibitors for the treatment of hair loss disorders. The issuance of this patent is another step in the development of a robust patent portfolio relating to JAK inhibition and hair loss,”

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