It appears that the gene-editing company Sangamo Therapeutics has an interest in hair growth technology. Sangamo is an interesting company with technology applications in gene therapy, genome editing, cell therapy, and gene regulation. Gene therapy, especially, is at the cutting-edge of medical technology innovation. The company has multiple therapies at phase 1/2 of the clinical trial process for various diseases.
NIZORAL???? What? Are u joking 🙃? NIZORAL make you loose hair , NIZORAL is not á shampoo is a synthetic imidazole antifungal drug used primarily to treat fungal infections. Ketoconazole is sold commercially as a tablet for oral administration (although this use has been discontinued in a number of countries), and in a variety of formulations for topical administration, such as creams (used to treat tinea; cutaneous candidiasis, including candidal paronychia; and pityriasis versicolor) and shampoos (used primarily to treat dandruff—seborrhoeic dermatitis of the scalp).
He now enjoys full scalp coverage, which he credits to modern transplant techniques combined with Propecia – but when he embarked on what he refers to as his “hair-loss journey”, there weren’t so many options. One trichologist advised him to dunk his head in freezing cold water six times per day; another zapped his scalp with infra-red light; finally, he opted for surgery. “The techniques were far less refined – 450 grafts,” he says. “Now, we can move 4,500 grafts in a single session. It left me with scars at the back of my head. And I committed to more and more procedures. Each time, they were taking another strip of tissue from the back of my head, leaving another scar.” He was eventually “fixed” at a surgery in Vancouver, but in his present role he talks people out of surgery as much as talking them into it. “I wish I could turn back the clock so I never had surgery,” he says.
If you’re looking for an au naturel option, look no further. This shampoo has been an Amazon best seller since 2012. It smells great, lathers well, and has no harsh chemicals mixed in. Pura d’or has elimated all the bad stuff from this shampoo—no Parabens or SLS. It does have a ton of good stuff too! Practically every clinically proven natural ingredient that aids against hair loss is packed into this shampoo. Nettles extract, he shou wu (fo-ti), argan oil, B vitamins, biotin, and saw palmetto.
But you must start these medical therapies before you lose all your hair. McAndrews likens it to brushing your teeth, in that both are preventative measures. “The sooner you start doing it, the better at slowing down this aging process,” he explains, adding, “Is toothpaste perfect? No, you’re still getting tooth decay with toothpaste, but you’re slowing down tooth decay.”
This shampoo has one of the top ratings of any shampoo sold online. KIMI Naturals must be doing something right! Saw palmetto, biotin, argan oil, and keratin are some of the highlight ingredients in this shampoo. They offer a 60 day money back guarantee, so if you’re not happy with the results after you give it a go, get you’re money back. On their KIMI Naturals website, they also sell a vitamin supplement and scalp treatment which they sell together with this shampoo as a 3-pack system.
Hair Surge contains three key ingredients: caffeine, ketoconazole, and saw palmetto. As already mentioned, all three are essential ingredients in any shampoo that’s truly targeted for hair growth. It doesn’t contain biotin, but you can always take biotin as a supplement if you absolutely feel that you have to have it. Besides, if you still have doubts that Hair Surge actually works, you can sift through the thousands of positive comments and testimonials about it online.
It's for this reason that grocery stores have shelves stocked full with hair care and hair grooming products of all forms and kinds, for different purposes, and even specialized and customized for use of men and women. In one study, it was found that more than half of the men in the UK use about six to ten hair grooming products alone, from the staple shampoos and conditioners to hair gels and other styling products.
Hair transplant surgery – which works by painstakingly moving grafts of hair (typically two to four follicles at a time) from the back of the head to the temples and crown, the first parts to drop – is becoming mainstream. Wayne Rooney was frank about his 48-hour, £30,000 follicular unit extraction at Harley Street Hair Clinic in 2011, and is widely credited with changing attitudes towards the procedure. Actor James Nesbitt had one as he feared he’d lose out on roles as a bald man. “It was something I struggled with,” he said, “and that was probably the vanity in me.”
I hope you’re having a good Friday. While I am a bit flabbergasted that out of the thousands of people who visit this article every week, still not one person has commented with an idea or practice that they can do to help hair growth treatments succeed, I feel the need to share some upliftment today. It’s coming from the original contributor of Feel Good Friday himself, Deion Sanders. A while back I shared a video of Deion getting his second FUE transplant to thicken his hair. The results are starting to come in and Deion could not be more enchanted by his own hair-restoration miracle. For a guy who was basically NW7 before restoration, the result is impressive. Enjoy his sentiments below.
David made this claim back in 2000. But fast-forward a few years and his enhanced compensation strategy begins to look a little quaint. Androgenetic alopecia, or male pattern baldness, afflicts about half of all men aged 50 and they can’t all reinvent the sitcom. And significant advances in the £3bn hair regrowth industry mean that they have other, seemingly easier, options. The man who is “ideally bald” (to use Vladimir Nabokov’s description of his comic hero, Pnin) may soon become a rare sight.
While techniques have advanced, the bald are no better served, says Spencer Kobren, who runs Bald Truth, a website and podcast in the lustrous world of the alt-bald media. He has learned to be highly suspicious of anything announcing itself as a cure; indeed, he resolutely fails to get excited about RT1640 or the Manchester findings. “I have been doing this for 20 years,” he tells me from his home in Beverly Hills. “When I wrote my book in 1998, they had just found the hair loss gene. There was talk of hair clones. There was a cell-based solution coming out of Japan. It was like: ‘This is it! We’re going to cure this in five years!’” He’ll believe it when he sees it.
Follicum announced yesterday it has successfully completed the development of a topical formulation for FOL-005. The company had been working in parallel to develop an optimal topical version of FOL-005 while an injectable version of the peptide was being used in a clinical trial. Now that the topical formula is completed it will be trialed in a further phase 2 clinical trial which will likely begin very late 2018 or early 2019.
An extremely popular organic product. There is significant evidence that biotin aids hair quality, while caffeine and saw palmetto are both somewhat beneficial to hair growth. Saw palmetto blocks the formation of dihydrotestosterone (DHT) and is often described as a natural (but weaker) alternative to finasteride. For more, see my post on natural cures for hair loss. This Botanical Green Care shampoo product also contains numerous other helpful ingredients such as nettle extract, panax ginseng, pumpkin seed oil, amla oil, bhringraj oil, niacin, vitamin A, vitamin E (alpha tocopherol) and more.
In the initial decade after the first identification of the hedgehog gene around 1980, there was almost no research devoted to the impact of the SHH pathway upon human hair. However, this started to change in the mid-1990s (e.g., this from 1998) and culminated in the seminal work on this subject that was published in the US in 1999: “Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog“.
For those of you who only check the Updates page, there was a new Brotzu Check-In article published yesterday. Giovanni Brotzu will be presenting data pertaining to his lotion’s use in androgenetic alopecia at an Italian hair research Congress this Saturday, April 14th. We hope to see photo results from the presentation. Check back to the Brotzu article next week for updates.
A bathroom covered with loose strands or an ever-scrawnier ponytail can be startling but doesn't necessarily mean anything's wrong. By age 50, half of women will complain of hair loss. "As we age, overall hair density changes and individual strands become finer," says dermatologist Doris J. Day, MD. But just because thinning is natural doesn't mean you have to accept it. Here are 13 solutions to help you keep the hair out of your brush and on your head.
Disruptions in the normal length of each phase, which can cause hair loss and hair thinning, may be the result of a number of internal and external stimuli. These are also what we call the triggers and causes of your hair loss. As a quick example, dieting can leave the body stressed and in need of important nutrients. Because of this stress, hair growth may be cut shorter than usual and there is an early onset of telogen or shedding of hair.
You might be surprised to know that some of those shampoos, conditioners, and styling agents have harsh chemicals that do a number on your hair. You may want to consider switching to softer hair care products that are designed to slow down hair thinning in men. DHT-blocking shampoos and conditioners containing ingredients such as ketoconazole and pyrithione zinc have shown some promise in helping reverse hair loss by potentially disrupting the production of DHT, the hormone linked to male pattern baldness. These
To us, that meant any product with zero proven ingredients, case studies, or FDA clearance — which shrunk our list by a whopping 180 contenders. That’s right, there are only three treatments that have actually been cleared by the FDA and supported with clinical studies: finasteride (commonly marketed as Propecia), minoxidil, and laser treatments. And, since finasteride is prescription-only, it left us with two.
Key features: The Thick & full Hair Growth Set by DermaChange is a go-to option for hair loss and thinning strands — it's chock-full of vitamins and oils that promote hair regrowth and prevent hair loss by hydrating, strengthening, and thickening strands with natural ingredients. It's also made with a gentle, sulfate-free formula, so it's a safe choice for color-treated hair and sensitive scalps.
Contact immunotherapy. Another drug that can be administered for cases of alopecia areata is contact immunotherapy and is recommended for severe cases. Diphenylcyclopropenon (DPCP) is applied on the scalp every week, and the dosage of the drug is increased over time until a mild allergic reaction is observed, which signals that the drug is taking effect. Regrowth may be observed within three months from the beginning of treatment.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact email@example.com for copyright questions and/or permission requests.
In their research, the doctors established a correlation between androgen hormones and hair loss. They found that for reasons not completely understood, some people are susceptible to androgens that attack the hair follicles, while others are not. “They found that the androgen hormone decimates the cell population at the base of the hair follicles,” Buckler said. “The hormone attaches to these cells throughout particular receptors and starts to attack.”
The combination of silent suffering, public shame and poorly understood science makes hair loss sufferers easy prey – type “hair loss” into Google and you’ll see what I mean. Kobren tells me that he had to remove the personal messaging function on the Bald Truth message board, as users were being bombarded by scams. Meanwhile, the higher visibility of celebrity transplants means that baldness is at risk of being seen as a sign of poor self-care. Many treat surgery lightly – and enter into punitive financing deals. One of Kobren’s recent guests was The Only Way is Essex star Maria Fowler, who complained that surgery at the controversial KSL Hair in Glasgow left her with an unnatural hairline. “She ended up having a hair transplant because her fiancé was having one. She had always thought her hairline was too high. She went in like she was having her nails painted – and it destroyed her life.”
Anagen is the growth phase. This lasts for about 3 - 5 years, where you can observe your hair growing half an inch every month. Full-length hair from this phase is about 18 - 30 inches long. Studies show that this phase may also be affected by other factors. Asian hair, for example, has been found to have a longer anagen phase. Weather is also a factor; hair growth can be faster in summer than in winter.
But there is a Canadian company who has been working diligently to change that. And if they’re right—and so far the research indicates they are—baldness may become a thing of the past for those who choose not to tolerate hair loss anymore. And they're not only attacking baldness, Aging skin and tendon degeneration are on the cutting block as well. It's great news for the tens of millions of older Americans who suffer from these malladies. But the most fascinating part lies in the source of the cure. It’s you. The company focuses on the development of cell therapies using a patient's own cells.
RepliCel is a regenerative medicine company focused on developing autologous cell therapies (or therapies that involve one individual as both donor and recipient) that address conditions linked to a deficit of healthy cells required for normal healing and function. Located in Vancouver, British Columbia, the company has developed first-of-their-kind cell therapies that will, they hope, treat conditions that now affect 1 in 3 Americans: pattern baldness, aging and sun-damaged skin, and chronic tendon degeneration.
In 2013, RepliCel began working with the Tokyo-based Shiseido Company, Limited—a Japanese multinational skin care, hair care, cosmetics and fragrance producer—on a collaboration giving Shiseido an exclusive geographic license to use RepliCel’s RCH-01 hair regeneration technology in Japan, China, South Korea, Taiwan and the ASEAN countries representing a population of approximately 2.1 billion people. “Shiseido and RepliCel will collaborate on the continued improvement of the technology and will conduct human clinical trials in each of their territories with the goal of commercializing a safe and effective hair regenerative treatment to help those suffering from pattern baldness and thinning hair,” Buckler said.
Christiano is more of a skeptic. Lab results are nice, she said, but “you can grow mouse or rat hair sixteen ways till Sunday. They grow beautifully!” She laughed. “Humans, not so much.” She points out that there’s so much we still don’t understand. For one: Why does the hair on the back of men’s heads stick around, even when all the rest drops? She also counsels caution when playing God with hair loss. Some companies are seeking hair-restoration cures by attempting to modify developmental-cell pathways. Those pathways, Christiano says, “are potent, and so it’s tempting, but you have to make sure it’s well enough controlled that you don’t initiate a cancer signal.”
3. Surgical hair replacement. If you opt for hair transplantation (which runs $5,000 and up), your dermatologist or hair-replacement surgeon will remove single hair follicles from the back of the head, near the nape of the neck, where your hair is fullest. Once those follicles are harvested, they are then dissected and reimplanted into an area of the scalp where hair is thinning. The procedure takes anywhere from three to six hours, and newly implanted hair will usually begin to grow on its own 3 to 12 months after the treatment session. Traditionally, hair transplantation required removal of an entire strip of scalp, Sadick says, but this new follicle-by-follicle technique looks more natural when it heals and allows patients to get heads of hair as dense-looking as before they started losing it.
Signage for Shiseido Co. is displayed outside the company's headquarters in Tokyo, Japan, on Friday, Feb. 28, 2014. Shiseido, Japan's largest cosmetics maker, is under reform after posting losses due to weak domestic sales and an impairment loss on goodwill associated with Bare Escentuals, which it bought in 2010. Photographer: Kiyoshi Ota/Bloomberg
Now known as RCH-01, RepliCel’s procedure is a patented cellular replication and implantation technology designed to rejuvenate damaged and miniaturized hair follicles in a balding scalp. According to Buckler, the technology involves the extraction of as few as 20 hair follicles from the back of a patient’s scalp where healthy cycling hair follicles reside. Specific cells are isolated from hair follicles and are cultured using the company’s proprietary cellular replication process. The cultured cells are reintroduced or injected back into balding areas on a patient’s scalp and are expected to rejuvenate damaged hair follicles leading to the growth of new healthy hair fibers.
Involutional alopecia. This one is less of a medical condition (it's not caused by a disease or genetics) and is more concerned with the hair growth cycle. Also called telogen effluvium, this condition is marked by a long dormant phase of telogen than growth or anagen. This type of hair loss is the second most common next to pattern baldness but is also the most unpredictable and difficult to pinpoint its cause. Studies have shown that the dormancy phase in the hair growth cycle is related to a range of factors, including hormonal imbalances, pregnancy in women, stress, diet, etc.
HairMax is known for their lasercomb products — an FDA approved hair loss treatment. They’ve started to branch out and now they offer a supplement, topical, and this shampoo (as well as a matching conditioner). One of the standout ingredients in this shampoo is the gotu kola. We have a full write up about gotu kola and its relationship to hair loss here.
If a pregnant woman comes in contact with crushed or broken Finasteride tablets, wash the contact area right away with soap and water. If a woman who is pregnant comes into contact with the active ingredient in Finasteride, a healthcare provider should be consulted. If a woman who is pregnant with a male baby swallows or comes in contact with the medicine in Finasteride, the male baby may be born with sex organs that are not normal.
It’s also possible that some of Harklinikken’s users are women whose hair would have grown back even if they’d done nothing. Many women who arrive in a dermatologist’s office with prior diagnoses of female pattern hair loss actually have what’s called telogen effluvium. That’s a period of acute shedding of hair — meaning up to 60 percent of hair — three months after a triggering event like pregnancy, significant weight loss or starting or stopping hormone medications.
“While nutritious eating isn’t going to bring your hair back by any means, eating plenty of protein-rich foods and healthy fats can make the hair that you still have look thicker and shinier.” Skimping on the B vitamins in particular can interfere with the formation of hair cells and, therefore, hair growth. The best sources of Bs are protein-packed foods like chicken, fish, eggs, and pork, as well as leafy greens such as spinach. (These foods are also good for melting belly fat, so it’s a win win).
Hey there, I'm Shawn, the founder of Tools of Men! This site was created to help out other guys by teaching them proper grooming habits and the basics of sensible style. We try to make things here a bit of fun while giving you clear info. If you want to get in touch with us, drop us a line on the contact page or via social media. Thanks for checking out the site - and make sure to come back again!
Nizoral is the gold-standard in hair loss prevention. Its main ingredient is ketoconazole. The nice thing about Nizoral is that you only need to use it twice a week (because ketoconazole binds to the proteins in your hair so it will keep working many days after use). If you were to use it daily your scalp would be drier than a desert and itchy as all heck.
Like the long-suffering friend who inspired her to undergo the procedure, Ms. Telford quickly saw an improvement in her hair. New hair growth usually take at least four months, but at the two-month mark, she has already spotted some baby hairs. “Not a gazillion,” she said, “but it’s a start.” She’s planning to return for follow-up treatments every six months, and has high hopes of ditching the wigs and wearing her hair in a pixie.
"Despite some of the claims, a shampoo or conditioner won’t be able to stop or slow hair loss, nor help with a receding hairline or thicken hair that’s becoming thinner," says trichologist Anabel Kingsley from The Philip Kingsley Trichology Clinic in London. "At best, a thickening shampoo will make hair temporarily thicker for a short period of time, but they certainly won’t help with hair loss or thinning."
Male patten baldness affects about 20% of men by the time they’re 20 and rises roughly in line with age: about 30% of men will experience significant hair loss by 30, 40% of men by 40, half of men aged 50, and so on. If you’ve retained your hair by middle-age, you’re one of the lucky ones. I’m elated to say that I’m well thatched at 37, but the grey specks in my beard bother me enough to know that if I did lose my hair, I’d be dismayed. For some reason, there is something inherently conical, sorry comical, about baldness; some people can deal with that and indeed, emerge stronger and surer of themselves. It’s fair to say Jason Statham wouldn’t have been a match for a prehistoric shark with his 1995 hair. But for others it’s just not so easy.
Minoxidil (Rogaine, generic versions). This drug was initially introduced as a treatment for high blood pressure, but people who took it noticed that they were growing hair in places where they had lost it. Research studies confirmed that minoxidil applied directly to the scalp could stimulate hair growth. As a result of the studies, the FDA originally approved over-the-counter 2% minoxidil to treat hair loss in women. Since then a 5% solution has also become available when a stronger solution is need for a woman's hair loss.
For hair transplant clinics, this is the ultimate goal. Bald people would make a mad dash to their clinics to get their new heads of hair. Since the main limitation of hair transplantation surgery is how many hairs can be harvested from the back of the scalp before it appears thin, stem cloning (the growing of dermal papilla cells) will solve that problem in totality. Recent research that has taken place in California has taken a big step toward the cure for hair loss.
The Rogaine rep we spoke to explained that the different packaging (and therefore different prices) has to do with the FDA-approval process: “We discovered in clinical trials that the hair loss patterns between men and women are different,” she said by way of explanation. “Men typically have that bald spot on the crown of their head, where women generally have a general thinning throughout, but concentrated more on the top of the head. So for FDA approval, we had to come up with two different, gender-specific products, so the directions were more explanatory.”
I asked Joseph what it might feel like to get his hands on an actual, proven hair-growth product. The question gave him pause. “It’s hard to put into words,” he said. “This would be the biggest, freeing, liberating thing for so many people. I mean, there would be smiles from coast to coast. That’s the best way I can respond to that question. I think people would be smiling from coast to coast.”
What’s equally frustrating for women is that their hair loss is not as clearly understood as hair loss in men and, according to an article in www.dermentz.org, “..presents itself quite differently from the more recognizable male pattern baldness which usually begins with a receding frontal hairline that progresses to a bald patch on top of the head.” The same article also says that it’s uncommon for women to follow a male pattern unless there is excessive production of androgens in her body.
Other options include microneedling ($1,200 and up per treatment) and platelet-replacement therapy (also $1,200 and up per treatment), which are usually offered in conjunction. Your scalp will be numbed first so you don’t feel the pinpricks involved in microneedling. They promote hair regeneration by spurring wound healing, and platelet-replacement therapy involves injecting growth factors into those wounds. “Combination therapy typically works better than monotherapy and usually yields results after three monthly treatments,” says Sadick, and should be teamed with an at-home minoxidil treatment.
There seems to be some contention over whether hair products like hair sprays, hair gels and serums can lead to hair loss. What's true though is that frequent use of these products can damage your hair, either make it thinner or more prone to breakage. Limit the use of these products for those occasions when you absolutely need to. If you use hair products with harsh chemicals, especially hair sprays, wash your hair at night with a mild shampoo to get rid of the chemicals.
The most common form of hair loss is androgenetic alopecia, or, in other words, male or female pattern baldness or hair loss. Androgenetic alopecia is genetic and affects an estimated 50 million men and 30 million women in the United States. Among white women in the U.S., an average of 19% are affected by female pattern hair loss, but that percentage increases with age. The prevalence is nearly doubled in Australia at 32% and much lower in Korea and China at < 6%. As of 2015, no studies had been done on the prevalence of female pattern hair loss in Brazil or Africa.
Jimenez, J. J., Wikramanayake, T. C., Bergfeld, W., Hordinsky, M., Hickman, J. G., Hamblin, M. R., & Schachner, L. A. (2014). Efficacy and Safety of a Low-level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-controlled, Double-blind Study. American Journal of Clinical Dermatology, 15(2), 115–127.
Patel said the problem with those treatments is that they have not been subjected to large or head-to-head research. There's great variation in how doctors give the plasma treatments and in laser-based devices, so it's hard for patients to know whether they're getting a proven regimen. Nutrafol seems promising, he said, but he does not think that company-funded research showing its effectiveness has been replicated. He has not recommended it yet.
Hair is made up of the hair follicle (a pocket in the skin that anchors each hair) and the shaft (the visible fiber above the scalp). In the hair bulb, located at the base of the follicle, cells divide and grow to produce the hair shaft, which is made from a protein called keratin. Papilla that surround the bulb contain tiny blood vessels that nourish the hair follicles and deliver hormones to regulate the growth and structure of the hair.
“The DHT hormone (dihydrotestosterone) can contribute to thinning in women who are genetically predisposed to female pattern thinning,” Fusco says. For those whose case falls into this category, she advises a prescription shampoo with ketoconazole 2 percent, as it has anti-androgenic properties. “Ketoconazole has been proposed to disrupt the pathway of DHT leading to thinning of follicles.”
RepliCel is a form of cell therapy that has a lot of folks excited. This is also known as RCH-01 and RepliCel is collaborating with global cosmetic company Shiseido. RepliCel will be an injectable like Histogen or Botox for example. It is basically hair transplants on steroids, but they are migrating cells instead of hairs. Their goal is to take a seed biopsy then multiply it in the lab for about 3 months. After replication, they inject it back into the scalp where it is needed. RepliCel has completed a phase 1 clinical trial and will enroll 160 male participants with mild to moderate hair loss for their Phase 2 trial. In other news RepliCel announced a research collaboration with University of British Columbia. They goal is to create a map with protein and gene expression of hair follicle cells to help RepliCel further improve their cell therapies i.e. hair loss prevention products.
In this section we take a look at current hair loss cures in 2018. Using one or more of the treatments below is your best shot at keeping your hair around. However, if a cure is defined as a permanent fix to an ailment, these are far from that definition. Each of these treatments have their own limitations. Most are seen more as hair loss management treatments, rather than permanent hair loss cures.
Kerastem, a company developing an autologous fat-derived stem cell therapy for hair growth, has reported positive data from their phase 2 trial. The results have come from a 6 month clinical trial involving 70 patients. In this study, the patients received a one-time injection of fat-derived stem cells, and purified fat, into their scalp. Kerastem reports an average increase of 29 hairs per cm2 from the treatment, or an increase of 17% from baseline. The press release does mention that the treatment “successfully stimulates hair growth in people with early stage hair loss”, so that is something to take into consideration when evaluating the results. For more info visit Kerastem’s website.
Other therapies for the treatment of alopecia areata include topical mid- to high-potency corticosteroids, minoxidil, anthralin, immunotherapy (diphenylcyclopropenone, squaric acid dibutylester), and systemic corticosteroids.12 Currently available therapies often yield unsatisfactory results, and some clinicians rely on the high rate of spontaneous remission or recommend a hairpiece or wig if remission does not occur.13
7/26/18 Update: After positive early data, various trials of JAK inhibitors such as Ruxolitinib and Xeljanz are underway. Columbia researchers have had positive results with Xeljanz in 11 out of 12 subjects achieving some regrowth with no adverse side effects over 16 months of treatment. Investigators at Stanford and Yale are conducting three trials of oral and topical tofacitnib and Locks of Love Foundation is fuding another ruxolitinib study. At this time, there are about 15 publications looking at JAK inhibitors and their relationship to alopecia and its variants.