As promised, I am providing an update on the highly anticipated development of Shiseido and RCH-01. This may not be the exact update everyone was hoping to hear, but nonetheless, progress and continued development are what we need to succeed. The update in summary is this: according to my source we will be getting the data from Shiseido’s trial of RCH-01 in 2019. There is no scheduled date for the data presentation, but I anticipate it would be within the 1st quarter of the year. 
Learn to get used to it. Men with balding hair would like to wear caps as a way to mask or cover-up their thinning hair. But while this is understandable, wearing a cap will not make the issue go away. Rather, by teaching oneself to get used to your new look, the easier it will be to accept and the less awkward you'd feel if you're out in public. Wear a hat only when necessary, that is, if you need scalp protection.
With those pinned down, it wasn’t hard to determine which don’t actually work. Pretty much all the “active” ingredients listed in ineffective treatments — from biotin and zinc to emu oil and saw palmetto — have never been proven, and are instead marketed based on logical-seeming correlations. It would make sense that biotin, a B vitamin readily found in hair, skin, and nails, could help hair grow more quickly. And caffeine is a stimulant that works in coffee, so rubbing some on your scalp might wake some of those sleepy follicles… right?
Originally spotted this on HairLossCure100’s twitter page. Concert Pharmaceutical’s therapy for alopecia areata, CTP-543, has been granted fast track designation from the FDA. CTP-543 is an oral JAK inhibitor (ruxolitinib). From what I’ve read, fast track designation encourages early and frequent communications between the FDA and the company during the development process to ensure issues and questions are resolved quickly.
But in November, after 10 years of research, Rogaine introduced a new 5 percent minoxidil formulation for women. It’s a mousse (instead of a liquid) that needs to be applied only once a day instead of twice, which means that it can be more easily incorporated into a woman’s evening skin-care routine. Teal replaces the blue and silver palette of the men’s Rogaine, and the packaging bears a lotus flower. (Also last year, Pantene introduced its Hair Regrowth Treatment for Women, which is 2 percent minoxidil.)

Lipogaine Big 3 does contain ketoconazole, but only a couple other hair loss/thinning related ingredients. Their Big 5 does not contain ketoconazole, but it does contain a proprietary mix of 17 ingredients for hair loss/thinning. It seems to be a more complete shampoo overall, aside from the hair loss aspects. My initial thought is to go with a combination of Big 5 and Nizoral.
The Rogaine rep we spoke to explained that the different packaging (and therefore different prices) has to do with the FDA-approval process: “We discovered in clinical trials that the hair loss patterns between men and women are different,” she said by way of explanation. “Men typically have that bald spot on the crown of their head, where women generally have a general thinning throughout, but concentrated more on the top of the head. So for FDA approval, we had to come up with two different, gender-specific products, so the directions were more explanatory.”
There have been recent discussions on Italian hair forum websites that indicate the Brotzu lotion may very well be moving ahead and preparing for imminent release. After commenter “Ahmed” brought it to my attention, I went back to check the Bellicapelli forum (the site which had the information on the Brotzu presentation at the Sitri Congress in April). I found a response from user “carlitos71” on this page which seems to display the new theories on the Brotzu lotion.
The general medical consensus around laser treatments — caps and combs alike — is that low-level laser light therapy stimulates the cells within the hair follicle. These devices may also increase cell metabolism to promote thicker and more durable hair shafts, something that neither minoxidil or finasteride can do. To use the HairMax Ultima, all you have to do is glide the device over your scalp slowly. Treatments should take about eight minutes, and you should do it three days per week for the best results.
Approved by the FDA and available in over-the-counter form for both men and women, minoxidil has been found to work in two out of three men. However, and this is a huge problem, if you stop using it, then your hair will actually fall out again and potentially faster than before. Plus, you might not even notice any changes until you’ve been using this medication for at least four months!
Aloe vera. Aloe vera is one of the most traditional and common natural hair loss treatments. It is known to possess enzymes that promote hair growth and a healthy scalp by regulating the hair and scalp's pH level. Known as a hair miracle, it is also used to treat other hair/scalp conditions like scalp itchiness, scalp redness, and inflammation. It also helps in minimizing dandruff and making the hair shinier and stronger.

Key features: This classic anti-dandruff shampoo by Nizoral uses ketoconazol, an anti-fungal medication, as its main ingredient to treat flaking, scaling, itching, or inflammation caused by seborrheic dermatitis, and is still gentle enough to be used on fine or thinning hair. It's meant to be used just twice a week in between regular shampoos to manage dandruff.


While diet alone won’t save your hair, there may be some truth to the old adage that you are what you eat. “You’re not going to have the healthiest hair if you’re living off doughnuts, because being nutrient-deficient weakens strands and makes them more prone to breakage,” says Denise Kernan, owner of DK Hair Techs, Inc., a member of the International Society for Hair Restoration Surgery, and a hair transplant technician who has worked on everyone from senators to sports stars to actors to mafia guys (she won’t name names to protect the privacy of her clients).
Jimenez, J. J., Wikramanayake, T. C., Bergfeld, W., Hordinsky, M., Hickman, J. G., Hamblin, M. R., & Schachner, L. A. (2014). Efficacy and Safety of a Low-level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-controlled, Double-blind Study. American Journal of Clinical Dermatology, 15(2), 115–127.

Trichotillomania may be difficult to diagnose if the patient is not forthcoming about pulling at his or her hair. Patients typically present with frontoparietal patches of alopecia that progress posteriorly and may include the eyelashes and eyebrows. Bare patches are typical, and the hair may appear uneven, with twisted or broken off hairs. Trichotillomania may lead to problems with self-esteem and social avoidance. Complications include infection, skin damage, and permanent scarring.18


Please help. My hair has always been my pride and joy. I figured since it is pretty damn healthy, it could deal with some bleach damage. And I figured the master stylist who did all the color-corrections would know how much would be too much. I was wrong, and now I want to burst into tears every time I look at my hair or touch it. I just don’t know what to do. my hair has also NEVER been shorter than this and it breaks and falls out. What should i do to regrow hair?
How about if you’d rather not get your head punctured? In Sweden, a company called Follicum is now doing Phase IIA clinical studies and planning to communicate results by the end of the year. The end product will be a cream or a lotion, one that could be applied as few as three times a week. In the first trial, Follicum claims, more than seventy-five per cent of patients experienced hair growth. This is the real dream, the one so artfully captured in the Hims ads: pop a pill, slap on some cream, and get Hair God locks.
Last fall, the San Francisco startup Hims began a small publicity blitz. Its ads were all over in-boxes and social-media feeds and TV screens; they were even out in real life, on paper placards. Above a picture of a handsome young man with long, luscious dark hair, there was a bold claim: “Thanks to science, baldness is now optional.” Hims, which also sells shampoos and erectile-dysfunction medication, has a minimalist aesthetic, designed by Partners & Spade. (The agency has done work for famed disruptors such as Warby Parker and Casper.) It also has an in-house journal called Savoir Faire. And, within all that attractive packaging and identity branding, the company was very casually offering the holy grail. My latent obsession led me to ask some questions of the ad campaign. It turns out that Hims’s baldness pills are just finasteride, and their topical solution minoxidil. Thanks to expired patents on those products, Hims is able to sell them cheap. And yet ultimately they’re providing the same old solution. Another false prophet.
Keranique Hair Regrowth 3-Piece Treatment Set for Women, Lipogaine for Women, Pantene Minoxidil 2% Hair Regrowth Treatment for Women, Prominox 1 Hair Loss Shampoo, Prominox 2 Hair Loss Conditioner, Prominox 3 Hair Growth Stimulator, Prominox 6 Leave-In Hair Loss Conditioner, REDKEN Cerafil Retaliate 2% Hair Regrowth Treatment for Women, Rogaine for Women Hair Regrowth Treatment
Sadick suggests avoiding “products with dyes and preservatives, like parabens and synthetic fragrances.” Ingredients that thicken the hair include amino acids, biotin, ginseng root, and menthol or peppermint oil — these are what you want to look for. “Amino acids provide the building blocks to build new strands, while biotin, part of the B-vitamin complex, is required by hair to metabolize amino acids and can help strengthen hair,” Sadick says. “Antioxidants such as vitamin E and ginseng are beneficial to promote hair growth because they reduce free radicals from sun, stress, or overprocessing and have anti-inflammatory properties.” Last but not least are the botanicals, which are great as they are rich in antioxidants and other compounds that stimulate blood flow and promote hair growth.
Over the past year, the Hair Restoration Laboratories’ Professional Strength DHT Blocking Hair Loss Shampoo (and accompanying DHT Blocking Hair Loss Conditioner) has been a top seller on Amazon and many other sites. Combined, the daily use Shampoo and Conditioner has more DHT blockers than any shampoo/conditioner set presently available. Among the key DHT Blockers in this set are: Caffeine, Saw Palmetto, Black Cumin Seed Oil, Cayenne Fruit Extract, Rosemary Leaf Oil, Pumpkin Seed Oil, Green Tea Leaf Extract, Pea Extract and many more. By helping to block DHT, they should be a great asset in helping to halt the miniaturization of the hair follicles and regrow healthier and thicker hair.
For hair transplant clinics, this is the ultimate goal. Bald people would make a mad dash to their clinics to get their new heads of hair. Since the main limitation of hair transplantation surgery is how many hairs can be harvested from the back of the scalp before it appears thin, stem cloning (the growing of dermal papilla cells) will solve that problem in totality. Recent research that has taken place in California has taken a big step toward the cure for hair loss.

RepliCel’s technology has proven to grow new hair without transplants, creams or pills because it’s using a patient’s own stem cells to regenerate hair. Buckler said the basis for the company’s science comes from research conducted in the early 2000s in Europe by noted hair biology and dermatology experts Dr. Kevin McElwee, PhD, and Dr. Rolf Hoffmann, MD, who originally discovered the critical cell responsible for hair follicle growth. It is now being tested in human Phase II trials that began in July 2016 in Japan. Two other products of the company are for conditions where there are too few healthy fibroblasts, such as chronic tendinosis and damaged skin.
Male patten baldness affects about 20% of men by the time they’re 20 and rises roughly in line with age: about 30% of men will experience significant hair loss by 30, 40% of men by 40, half of men aged 50, and so on. If you’ve retained your hair by middle-age, you’re one of the lucky ones. I’m elated to say that I’m well thatched at 37, but the grey specks in my beard bother me enough to know that if I did lose my hair, I’d be dismayed. For some reason, there is something inherently conical, sorry comical, about baldness; some people can deal with that and indeed, emerge stronger and surer of themselves. It’s fair to say Jason Statham wouldn’t have been a match for a prehistoric shark with his 1995 hair. But for others it’s just not so easy.

Head over to the main Articles page to read an update from head researcher Junji Fukuda PhD of Yokohama National University. This is the research that spurred the “french fry hair cure” craze of recent news headlines. I asked Junji in a Q&A if he has received any interest from bigger companies to commercialize his technology. Find his answer and more insight to what lead him to hair follicle research in the full article.


NIZORAL???? What? Are u joking 🙃? NIZORAL make you loose hair , NIZORAL is not á shampoo is a synthetic imidazole antifungal drug used primarily to treat fungal infections. Ketoconazole is sold commercially as a tablet for oral administration (although this use has been discontinued in a number of countries), and in a variety of formulations for topical administration, such as creams (used to treat tinea; cutaneous candidiasis, including candidal paronychia; and pityriasis versicolor) and shampoos (used primarily to treat dandruff—seborrhoeic dermatitis of the scalp).
Her hope is that the procedure (she has helped start a company named Rapunzel to develop it) will eventually become another lunchtime cosmetic treatment. Once a patient has had her cells harvested and cultured, they could be stored indefinitely; then, after giving her doctor a month’s notice (the time it takes to grow the million needed), she could pop in for injections. Costs would likely be on par with hair transplants, roughly $10,000 and up.
Our specially formulated natural remedy for hair loss and shedding is made with natural ingredients. We use high quality products, such as D Panthenol, tea tree oil and evening primrose, to nourish the scalp. This eliminates current hair loss and prevents future problems. It targets the root of falling hair, and penetrates the scalp and hair follicles for itch free, flake free skin that is nourished and ultra hydrated. Our formula rejuvenates and regenerates skin and hair follicles for revitalized, beautiful hair.
Another type of hair loss is alopecia areata, in which hair on the head (and sometimes on the body) falls out in patches. In most cases this type of hair loss resolves itself within a few months, however in some cases it can lead to more severe forms of hair loss such as alopecia totalis (loss of all hair on the scalp) or alopecia universalis (loss of all hair on the body). Alopecia areata is most common in people aged 15-29 and there are various treatments for it: minoxidil, corticosteroid injections, topical corticosteroid creams or lotions, dithranol cream, immunotherapy and light therapy. However none of these can be thought of as a cure for alopecia areata, as they are only temporary solutions.
Anagen is the growth phase. This lasts for about 3 - 5 years, where you can observe your hair growing half an inch every month. Full-length hair from this phase is about 18 - 30 inches long. Studies show that this phase may also be affected by other factors. Asian hair, for example, has been found to have a longer anagen phase. Weather is also a factor; hair growth can be faster in summer than in winter.

In fact, research posted in the Journal of Dermatology found that ketoconazole was effective in treating mice for dermatitis and hair loss. In clinical trials, researchers found that 15 men who used finasteride, minoxidil, and ketoconazole for a 90-day period benefitted from hair growth, getting a noticeably thicker head of hair than what they had at the beginning of the studies.
There’s a lot of misinformation, half-truths, and pseudoscience regarding hair loss, and there are also treatment programs that have been well-researched and tested in clinical settings. So, how do you find the difference? For starters, talk to the experts in the industry like dermatologists and general physicians about treatment programs. Avoid people advertising secret cures, all-natural remedies, and permanent fixes. If there was a way to stop baldness from happening, we’d all know about it already.
Scientists from the Indiana University School of Medicine have for the first time created skin with hair follicles using mice stem cells. Research was led by Professor Karl Koehler. The team was able to grow both the epidermis and dermis layers of skin to create a realistic skin model. An interesting quote from Professor Koehler: “It looks like a little ball of pocket lint that floats around in the culture medium. The skin develops as a spherical cyst and then the hair follicles grow outward in all directions – like dandelion seeds.”
There have also been studies on the effects of 1% pyrithione zinc shampoo and a 5% minoxidil solution. In one study, 200 men between the ages of 18 to 49 who experienced baldness between type III and type IV on the Norwood scale were given this treatment for a six-month period. They found that minoxidil, when used on its own, was approximately twice as powerful as pyrithione zinc at stimulating hair growth, but that both products were successful at increasing the amount of visible hair when used over a 26-week period.
3. Hair fibers. The best (and easiest) way to hide a widening part or sparse patch is with hair fibers. They’re tiny, charged fibers that adhere to your scalp (until your next shampoo). Toppik Hair Building Fibers ($25) come in a range of colors so you can easily find one that matches your own hair. (In a pinch, you can also brush a powdered eye shadow that matches your hair color along your part.)

You might think, "It's just hair", but think about this: What would you do if you wake up one day without a single strand of hair on your head? However, as we've mentioned, hair loss is a natural physiological process. In the hair growth cycle, old hair has to be shed in order for new hair to grow. As we age, our body's capacity to produce hair also slows down, similar to when our bones stop growing at a certain point in our lives.


Other therapies for the treatment of alopecia areata include topical mid- to high-potency corticosteroids, minoxidil, anthralin, immunotherapy (diphenylcyclopropenone, squaric acid dibutylester), and systemic corticosteroids.12 Currently available therapies often yield unsatisfactory results, and some clinicians rely on the high rate of spontaneous remission or recommend a hairpiece or wig if remission does not occur.13

You may not know it, but stress affects your health in a number of different ways. It can zap your energy, make you feel physically ill, and even cause your hair to fall out. That’s right, stress plays a big role in contributing to thinning hair. On its own, stress-related hair loss is usually temporary and grows back over time. However, it can also speed up other forms of hair loss like male pattern baldness.
Regarding the RCH news, is your source more reliable than Lee Buckler since he seems to know more about RCH than Lee buckler himself. Recently, Lee Buckler tweeted “We anticipate seeing data from the RCH-01 study in Japan sometime before year-end but the real answer is whenever the investigators/hospitals in charge of the trial (not us) decide to release the data once it ready”
Chronic dandruff can also lead to hair shedding if it’s left untreated or undertreated. “Many women with dandruff don’t use a dandruff shampoo regularly because they are concerned with the lack of cosmetic elegance and the concern that it won’t beautify their hair,” Fusco explains. “A dandruff shampoo and conditioner that contain ZP [zinc pyrithione] and ingredients that beautify the hair can be used every day, as they will control dandruff, reduce inflammation, and thereby diminish shedding.”
A little farther up the follicle is the mysterious feature called the bulge. That's where follicle stem cells live. When they get the right set of chemical signals, these self-renewing cells divide. They don't divide like normal cells, in which both halves become new cells that keep splitting and developing. Only one half of the follicle stem cell does that. The other half becomes a new stem cell, and stays put for future regeneration.
Our hair is part of what we call the integumentary system of the human body, which also includes the skin and nails. Hair is, in fact, a type of modified skin. It is made up of keratin, a form of protein, and is produced in tunnel-like structures in the skin called follicles. Inside the hair follicle is the hair bulb that is comprised of cells that deposit keratin and melanin, which is responsible for giving your hair its color. The hair that breaks through your skin from the follicle is the hair shaft. The shaft is basically composed of dead cells comprised of keratin fibres. In fact, the totality of hair on our head is a huge lump of dead cells, which explains why we don't experience any pain when we go for a haircut.

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Hair transplants will likely lead to better results in the long run (you are introducing new hairs to the balding areas), but you’ll still need to use minoxidil or finasteride after surgery to maintain the results. Like all hair loss treatments, hair transplants are best when combined with other methods, and you’ll want to speak with your doctor to see what combination is best for you.
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