If you have something that works for you, don’t change. Search for products that have plenty of positive feedback and don’t just trust Amazon reviews, but dig deeper. Again, most shampoos that claim to halt hair loss and grow new hair are nothing more than snake oil. Stick with ingredients that are clinically proven to work and backed by scientific study.
In 1952, a New York dermatologist named Norman Orentreich invented hair plugs. He removed hair from the back of a patient’s head, where it still grew, and grafted it onto the front. In the decades since, the transplantation process has become more refined. Following the lead of the pioneering dermatologist Robert Bernstein, most doctors perform follicular-unit extraction; instead of crudely ripping up large parts of the scalp, they pluck and move individual follicular units.
Nioxin is available in literally dozens of options, but the most common packages are two-step (shampoo & conditioner) and three-step (shampoo & conditioner & leave-in scalp treatment). While there are no hard studies done on the efficacy of Nioxin, P&G has pointed to a study where 70% of Nioxin users notice denser, thicker looking hair after four weeks using the Nioxin 3-part system.
The optimal treatment for this condition is not known, and psychiatric referral may be indicated. Treatment options include cognitive behavior therapy19 and selective serotonin reuptake inhibitors, although strong evidence of a treatment effect has not been demonstrated. Preliminary evidence suggests positive treatment effects with acetylcysteine, olanzapine (Zyprexa), and clomipramine (Anafranil).19 A combination of cognitive behavior therapy and medications may be more effective than either approach alone.19
Bumble & bumble had fine-haired beauties in mind when creating this super-moisturizing (but still super-weightless) formula. The shampoo’s trifecta relies on damage-controlling panthenol (or you as you may know it, vitamin B5), strengthening wheat protein, and scalp-loving, deep-conditioning aloe vera. Strands are left prepped for big, voluminous blowouts or to be hand-tousled for texture, movement, and shine.
Researchers from South Korea have identified a new peptide called PTD-DBM which exhibits wound healing and hair regeneration effects in preclinical studies. The research is being led by Professor Kang-Yell Choi of Yonsei University. Choi’s team identified the peptide PTD-DBM which targets a protein called CXXC5. The interaction of these two proteins leads to stimulation of the Wnt pathway, which then initiates hair follicle neogenesis. Choi hopes to develop this peptide further into a potential hair growth drug candidate. A research paper about these findings was put out by the team earlier this year. Source article about this development here.
After the new article featuring Medipost’s hair growth cosmetic was published, Jay Lee PhD of Medipost, began chiming in on the comments section. He first shared that Medipost is currently engaging in a larger clinical trial for the CM3 product which would include higher scale Norwood’s. Then, in a following comment he revealed that Medipost is developing a potentially more advanced hair growth product as well. Here are his words:
“No probs. If you come across any other documentaries in the UK that you cannot view in the States feel free to ask me to watch it and feedback. I think sites like yours give people an incentive to keep looking forward with some optimism. Without doubt a feasible hair loss solution isn’t far away. I think it will most likely be a next gen hair transplant through hair cloning. But what ever it might be, as you said in a previous comment there have never been as many players in the hair loss industry. There will be a few false starts, but one, quickly followed by others will come through. It’s just the wait 🙁 But you never know with Shiseido, Brotzu and Haircell releasing data this year it could be sooner than we think 🙂 Kind regards” – Welsh Dragon
It wasn’t quite the “accident” it was portrayed to be. He worked out that the drug targeted a protein called SFRP1, which affects follicle growth. He looked into the literature and discovered there was a pre-existing osteoporosis drug, WAY-316606, designed to target this protein with much more precision. So he applied that to leftover slabs of scalp donated by hair transplant clinics. “We usually do experiments for over a week. We put the hair follicles in a dish and this drug enhanced hair shaft elongation within two days. But it also kept the hairs healthier. When you look at them, they’re larger, thicker hair follicles. So, it’s quite promising.”
Patients with tinea capitis typically present with patchy alopecia with or without scaling, although the entire scalp may be involved. Other findings include adenopathy and pruritus. Children may have an associated kerion, a painful erythematous boggy plaque, often with purulent drainage and regional lymphadenopathy. Posterior auricular lymphadenopathy may help differentiate tinea capitis from other inflammatory causes of alopecia. If the diagnosis is not clear from the history and physical examination, a skin scraping taken from the active border of the inflamed patch in a potassium hydroxide preparation can be examined microscopically for the presence of hyphae. Skin scrapings can also be sent for fungal culture, but this is less helpful because the fungi can take up to six weeks to grow.
A little farther up the follicle is the mysterious feature called the bulge. That's where follicle stem cells live. When they get the right set of chemical signals, these self-renewing cells divide. They don't divide like normal cells, in which both halves become new cells that keep splitting and developing. Only one half of the follicle stem cell does that. The other half becomes a new stem cell, and stays put for future regeneration.
3. Hair fibers. The best (and easiest) way to hide a widening part or sparse patch is with hair fibers. They’re tiny, charged fibers that adhere to your scalp (until your next shampoo). Toppik Hair Building Fibers ($25) come in a range of colors so you can easily find one that matches your own hair. (In a pinch, you can also brush a powdered eye shadow that matches your hair color along your part.)
Egg mask. Eggs are one of the riches sources of protein, which is the building block of keratin, as well as other minerals like zinc, iron, selenium, phosphorous and iodine. Mix an egg white with a tablespoon of olive oil and honey to make a paste. Apply it on your hair and leave on for 20 minutes. Rinse and shampoo using cold water. You can apply this egg mask on your hair once a week.
Pfizer Reports Positive AA Trial Results – A JAK3 inhibitor and a tyrosine kinase inhibitor (TYK2/JAK1) have shown statistically significant results in a phase 2a trial conducted by Pfizer. The company announced the results on September 15, 2018 at the European Academy of Dermatology and Venerology Congress. Subjects of the trial received oral doses of the drugs over a 6 month period. The TYK2/JAK1 inhibitor showed the greater efficacy, improving hair regrowth by 49.5 points on the Severity of Alopecia Tool scale, compared to an improvement of 33.6 points by the JAK3 inhibitor. However, Pfizer has apparently decided to move forward with its JAK3 inhibitor due to 2 adverse events in the TYK2/JAK1 inhibitor cohort during the trial. Pfizer’s JAK3 candidate, PF-06651600, was also recently granted Breakthrough Designation from the US FDA for treating alopecia areata.
“I think their effectiveness is not as significant as finasteride or minoxidil,” says Dr. Wolfeld, “however, it’s something that can be used quite easily by patients at home. If they use it two or three times a week, I tell them it can help to thicken their hair.” Results can take up to 18 months to show up, so Dr. Wolfeld stresses that patience is a virtue.
While thinning generally worsens after menopause, doctors said hormone treatments typically do not improve hair growth. Minoxidil lotion or foam, which can be purchased over the counter, is the first line of treatment. About half of women who use it have not lost more hair a year later, Cotsarelis said. Spironolactone, a blood-pressure drug, can also help, doctors said. Some may also try finasteride — approved to treat baldness in men — off-label. The evidence that it works in women is weak, Patel said.
The key ingredient in Nizoral is ketoconazole, which reduces hair follicle inflammation that contributes to hair loss. Ketoconazole also kills fungi that cause dandruff, but there’s not so much of it as to be toxic (which large amounts of ketoconazole can be). It has been argued that dandruff may contribute to hair loss; while there’s no direct link, it’s certainly worth noting here.
Alexey Terskikh PhD of Sanford Burnham Prebys research institute has news to share about his hair follicle research. The Articles page gives you all the highlights on what advancements Terskikh has made over the past three years and when he is planning to take his cloning method to FDA human trials. This is one example of a peer reviewed journal article which actually developed to human translation in a timely manner. Happy Friday
McElwee is an associate professor in the Department of Dermatology and Skin Health at the University of British Columbia (UBC) in British Columbia, Canada and director of the Hair Research Laboratory in the Vancouver Coastal Health Research Institute (VCHI) at Vancouver General Hospital (VGH). A hair research scientist, McElwee is one of only a small group of research scientists worldwide who studies hair biology and associated diseases.
The thing is that these big drug companies have shelled out millions and even billions of dollars to research, develop, market and then sell a drug-based product that consumers want. Therefore, they will do everything in their power to protect and guard their products against any drug-free alternatives. The kicker is even if said alternatives are cheaper and safer for consumers, while also achieving the same goals for them! This is the crux of claim enforcement, which is really about claim ownership and claim protection from the perspective of the big drug companies.
In 2013, RepliCel began working with the Tokyo-based Shiseido Company, Limited—a Japanese multinational skin care, hair care, cosmetics and fragrance producer—on a collaboration giving Shiseido an exclusive geographic license to use RepliCel’s RCH-01 hair regeneration technology in Japan, China, South Korea, Taiwan and the ASEAN countries representing a population of approximately 2.1 billion people. “Shiseido and RepliCel will collaborate on the continued improvement of the technology and will conduct human clinical trials in each of their territories with the goal of commercializing a safe and effective hair regenerative treatment to help those suffering from pattern baldness and thinning hair,” Buckler said.
Women’s magazine ‘New Beauty’ recently featured several prospective hair growth therapies in a print article. The feature contains several interesting and worthwhile anecdotes. Check the Articles main page to read about Dr. Cotsarelis’ new research on setipiprant for female alopecia, Histogen’s view on the number of injection sessions which may be necessary to get the most out of HSC, and more.
Before deciding on the best shampoo for thinning hair, you'll want to figure out what the underlying cause is. According to Dr. Zeichner, the most common causes of hair loss are chronic tension on the hair follicles, breakage from chemical process treatments — which include perms, relaxers, or hair dye — and severe dandruff or scalp psoriasis. Chronic medial conditions, such as autoimmune diseases, are also a common reason for hair loss, so if you're unsure of the cause, it's important to see a doctor to rule out other possible conditions.
In Michael Wolff’s “Fire and Fury,” Kuntzman’s theory is bolstered. Wolff writes that Ivanka Trump “often described the mechanics behind it to friends: an absolutely clean pate—a contained island after scalp-reduction surgery—surrounded by a furry circle of hair around the sides and front, from which all ends are drawn up to meet in the center and then swept back and secured by a stiffening spray.”
While not a cure for hair loss, this will clear up the muddy waters no doubt. DNA-testing is just starting to be commercially available and by 2020 you’ll be able to count on the likelihood that it will be much more advanced and affordable. Knowing for a fact at an early age whether or not someone will be predisposed to losing their hair will make a huge difference. This will help that individual be able to plan, budget, and research their options before their hair even begins thinning.
The Holy Grail remains a drug that will promote regrowth, but this might not be so far away. Earlier this year, Manchester University announced that an osteoporosis drug had been found to have “dramatic results” promoting hair growth when applied to tissue samples in pre-clinical trials. The resultant frenzy left the PhD student responsible, Dr Nathan Hawkshaw, a little dazed. “Every other week, something comes out about hair loss and it doesn’t generate as much media coverage as what I experienced,” he grumbles. He’s in this for the science – there aren’t many fields where you get to mess around with real human tissue – but such is the distress caused by hair loss and such is the potential customer base that interest is always high.
But here's one thing that most people miss when they talk about hair loss: It's part of the natural process of the hair growth cycle. Shedding hair is normal, and losing hair as we age is normal. However, there are instances when we are shedding hair at an abnormally faster rate than usual - and this is something that we have to pay attention to. It's also perfectly understandable and acceptable that some people would like to reverse the hair loss that comes as part of the aging process.
Hair loss in alopecia areata occurs in three different patterns: patchy alopecia is circumscribed, oval-shaped, flesh-colored patches on any part of the body; alopecia totalis involves the entire scalp; and alopecia universalis involves the whole body. Evaluation of the scalp may reveal short vellus hairs, yellow or black dots, and broken hair shafts (which are not specific to alopecia areata). Microscopic examination of the hair follicles demonstrates exclamation mark hair (i.e., hairs that are narrower closer to the scalp and mimic an exclamation point; Figure 44). Nail pitting is also associated with alopecia areata.
Minoxidil and oral finasteride are the only treatments currently approved by the U.S. Food and Drug Administration for the treatment of androgenetic alopecia. Both of these drugs stimulate hair regrowth in some men, but are more effective in preventing progression of hair loss. Although there are a number of other treatments listed in various texts, there is not good evidence to support their use.8
We've heard it all before: clients waking up one day in shock after discovering a coin-sized bald spot on their heads; women agonizing over the strands of hair they see on the shower floor; men looking for topical creams and shampoos to prevent the early onset of balding. Even more are tales of men and women on the search for the perfect wig or toupee to cover up the loss of their hair as a result of medication for a chronic illness.
Along with male pattern baldness, there is also a condition known as female pattern baldness, in which hair thins on the top of the head. Less is known about this type of hair loss, but it is more common in women who have been through the menopause. Female pattern baldness cannot be treated with finasteride (as with male pattern baldness), but it can be treated with minoxidil. Minoxidil is rubbed into the scalp once or twice a day and should start to show results after about four months. After ceasing treatment with minoxidil, hair loss should resume within a few months.