Category: Alopecia Areata, Alopecia Pipeline, Hair Care Products, Hair Growth Pipeline Tags: Alopecia News, Autoimmune Disease Hair Growth, Carboxytherapy For Alopecia, Cures For Hair Loss, Cures For Hair Loss Coming Soon, Cynata Therapeutics, Deion Sanders Hair, Deion Sanders Hair Transplant Results, Gray Hair Cure, Grey Hair Cure, Hair Growth Cosmetic, Hair Loss Cure, Hair Loss News, Hair Stem Cell Cosmetic, JW Pharma Wnt Hair Growth, Organ Technologies Hair Cloning, PTD-DBM Hair Growth, Sandalore, Switch Biotech Hair Growth, WAY-316606 Hair Growth, Yonsei University Hair Research
Researchers from UCLA in the lab of Jing Huang have recently shown that certain molecules which activate the cellular process known as autophagy also drive hair follicles into the anagen (growth) phase. The researchers studied different metabolite molecules and other molecules which are FDA approved and on the market as drugs. The most recognizable drugs from the study were metformin and rapamycin, one is a diabetes medicine and the other an immunosuppressant. Dr. Huang says her lab is looking to study these drugs for human hair growth soon. In my opinion, results from that study are something to look out for. Full article on the Articles page.
Anagen is the growth phase. This lasts for about 3 - 5 years, where you can observe your hair growing half an inch every month. Full-length hair from this phase is about 18 - 30 inches long. Studies show that this phase may also be affected by other factors. Asian hair, for example, has been found to have a longer anagen phase. Weather is also a factor; hair growth can be faster in summer than in winter.

In Michael Wolff’s “Fire and Fury,” Kuntzman’s theory is bolstered. Wolff writes that Ivanka Trump “often described the mechanics behind it to friends: an absolutely clean pate—a contained island after scalp-reduction ­surgery—surrounded by a furry circle of hair around the sides and front, from which all ends are drawn up to meet in the center and then swept back and secured by a stiffening spray.”
In most cases though, it's all a matter of attitude. Being bald should not be a cause of stigma. It does not make you less of a person or less masculine, less virile, and less attractive and appealing. In fact, a clean shaven head is becoming a popular trend among men these days, and there are certainly many bald men who have managed to make themselves look clean, elegant and suave despite their hair loss. Learn to come to terms with it. It's hair loss, yes, but not brain damage. It does not affect your core.
In Michael Wolff’s “Fire and Fury,” Kuntzman’s theory is bolstered. Wolff writes that Ivanka Trump “often described the mechanics behind it to friends: an absolutely clean pate—a contained island after scalp-reduction ­surgery—surrounded by a furry circle of hair around the sides and front, from which all ends are drawn up to meet in the center and then swept back and secured by a stiffening spray.”
David made this claim back in 2000. But fast-forward a few years and his enhanced compensation strategy begins to look a little quaint. Androgenetic alopecia, or male pattern baldness, afflicts about half of all men aged 50 and they can’t all reinvent the sitcom. And significant advances in the £3bn hair regrowth industry mean that they have other, seemingly easier, options. The man who is “ideally bald” (to use Vladimir Nabokov’s description of his comic hero, Pnin) may soon become a rare sight.
“The most common cause of hair loss in both men and women is androgenetic alopecia, which is genetic pattern hair loss,” explains Dr. Michael B. Wolfeld, a board-certified plastic surgeon and an assistant clinical professor of plastic surgery at the Icahn School of Medicine at Mount Sinai Hospital in New York. The root cause of this type of hair loss is dihydrotestosterone (DHT), a byproduct of testosterone that shrinks certain hair follicles until they eventually stop producing hair. 

The most common form of hair loss is androgenetic alopecia, or, in other words, male or female pattern baldness or hair loss. Androgenetic alopecia is genetic and affects an estimated 50 million men and 30 million women in the United States. Among white women in the U.S., an average of 19% are affected by female pattern hair loss, but that percentage increases with age. The prevalence is nearly doubled in Australia at 32% and much lower in Korea and China at < 6%. As of 2015, no studies had been done on the prevalence of female pattern hair loss in Brazil or Africa.

Anagen effluvium is abnormal diffuse hair loss (usually abrupt) during the anagen phase due to an event that impairs the mitotic or metabolic activity of the hair follicle. The incidence of anagen effluvium after chemotherapy is approximately 65%24; it is most commonly associated with cyclophosphamide, nitrosoureas, and doxorubicin (Adriamycin). Other causative medications include tamoxifen, allopurinol, levodopa, bromocriptine (Parlodel), and toxins such as bismuth, arsenic, and gold. Other medical and inflammatory conditions, such as mycosis fungoides or pemphigus vulgaris, can lead to anagen effluvium.25


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Always shampoo and condition your hair regularly. Let your hair breath by avoiding wigs that are made with cotton and nylon caps that absorb moisture and lead to drier and more damaged hair. Instead, choose those with netted caps. Make sure your wig isn't too tight. Secure it with hypoallergenic double-sided tapes. Do not put your wig on over wet hair to avoid the growth of mildew and bacteria. 

I also reached out to Histogen and Follicum a few weeks ago as well thanking them for all their hard work in bringing a safe and effective treatment to people all over the globe with hairloss issues and expressed how much we all value these companies. I held back from asking about market release as you had suggested. I received a very nice reply from Histogen.
Laser treatments are the latest frontier in staving off hair loss, and they’ll be the first choice for fans of sci-fi. As silly as they may sound, these treatments do work — the American Journal of Clinical Dermatology in 2014 reported a “statistically significant difference” in hair density with no “serious adverse events” or side effects.The bad news: Laser treatments tend to be expensive, progress is slow, and they don’t always produce stellar results.

Dr. Carlos Wesley, a hair restoration surgeon in Manhattan, said that women in his practice respond better to P.R.P. than men do, which may have something to do with the fact that women with genetic hair loss tend to have more inflammatory cells around the follicles. From 2013 to 2014, he said, he had an 83 percent increase in female patients, in part because of P.R.P.
To do the exercise, simply rub the fingernails of both hands - except the thumbs - against each other as hard as possible. Make sure not to let the surface of the nails rub against each other - just the tips. In acupressure therapy, it is believed that the hair follicles on the scalp are connected to the fingernails and by doing the exercise, it will stimulate blood circulation and nutrients into the follicles, therefore promoting hair growth.
The cause of female-pattern hair loss is unknown, but doctors said there is a strong genetic component. The risk can come from male or female relatives. Though it looks as if the hair is falling out, that's not really what's happening. Cotsarelis said hair follicles are becoming smaller and producing hairs that may be so small that you can't see them.  Women tend to retain more normal, thick hairs than balding men do.
Last fall, the San Francisco startup Hims began a small publicity blitz. Its ads were all over in-boxes and social-media feeds and TV screens; they were even out in real life, on paper placards. Above a picture of a handsome young man with long, luscious dark hair, there was a bold claim: “Thanks to science, baldness is now optional.” Hims, which also sells shampoos and erectile-dysfunction medication, has a minimalist aesthetic, designed by Partners & Spade. (The agency has done work for famed disruptors such as Warby Parker and Casper.) It also has an in-house journal called Savoir Faire. And, within all that attractive packaging and identity branding, the company was very casually offering the holy grail. My latent obsession led me to ask some questions of the ad campaign. It turns out that Hims’s baldness pills are just finasteride, and their topical solution minoxidil. Thanks to expired patents on those products, Hims is able to sell them cheap. And yet ultimately they’re providing the same old solution. Another false prophet.
A clinical researcher who has spent decades researching the fields of pattern hair loss, alopecia areata, endocrinology of the hair follicle and hair follicle morphogenesis, Hoffmann works in his private practice, as a teaching professor in the Department of Dermatology at the University of Marburg and as a researcher on histopathology on hair diseases. He has participated in dozens of clinical hair studies and is the inventor of TrichoScan®, a computerized technique to measure hair growth.
More good research coming from the University of Alabama at Birmingham shows that a certain gene affecting mitochondrial function can dramatically reverse signs of aging in mice. The aging factors which were shown to be reversible include skin wrinkles, gray hair, and hair loss. Next comes the important phase where the researchers continue forward to translate this discovery to human use. Full article on the front page.
Chemotherapy is also one of the primary causes of balding among cancer patients, men and women alike. While not all chemotherapy treatments result in hair loss, some that involves the use of drugs like Altretamine, Carboplatin, Docetaxel, and Idarubicin can cause hair thinning and hair fall. In such cases, the hair loss varies from person to person and the dosage of drugs administered. Hair fall doesn't occur at once, but rather after several weeks of treatment until hair fall rate increases after one or two months of exposure to chemotherapy. Radiation therapy as part of cancer treatment can also result into hair loss but typically only in areas where the radiation is targeted.
Lee Buckler, CEO of Replicel, stated in an interview this week that he expects Shiseido to release clinical trial results in 2018. This is great news that everything is still on track for the anticipated 2018 release of Replicel’s RCH-01 technology in Japan. Lee mentioned “It’s entirely up to Shiseido what they do in regards to this product. There’s certainly a possibility that they could decide if the data is positive, to launch the product in Japan…”. Yes, it seems likely that if the data is positive, Shiseido would go to market with one of the biggest technological breakthroughs of the century. Full interview here. 
Literally jumping right out of the woodwork, the company “HCell” has announced they have been granted an orphan designation from the US FDA for their novel treatment of pediatric alopecia areata. The treatment itself it described as a “topical Injection by regenerating hair through a proprietary blend of commercially procured biologic and autologous tissue.” The company also mentions having a treatment for androgenic alopecia in the works as well. More info to come soon. News release here. 
Always shampoo and condition your hair regularly. Let your hair breath by avoiding wigs that are made with cotton and nylon caps that absorb moisture and lead to drier and more damaged hair. Instead, choose those with netted caps. Make sure your wig isn't too tight. Secure it with hypoallergenic double-sided tapes. Do not put your wig on over wet hair to avoid the growth of mildew and bacteria.
Your hair can suffer from many health-related factors. A diet that is lacking in vitamins and minerals lack proper hydration as well as damage from styling. Make sure you eat a varied and balanced diet with plenty of nutrient-rich foods including fruit and vegetables. Try and limit using heat to style. This includes hairdryers and straightening irons.
DS Laboratories have covered all the bases with this shampoo, circulation, cleansing action, and anti-DHT properties. It starts acting on the first day of use but most users of the shampoo start to see results after about 4-6 months of use. When you wash with the shampoo, you leave it on the scalp for about 2 minutes before rinsing to allow you scalp to absorb all the ingredients. For the best results, DS Laboratories suggest using Revita at least 5 times per week.

Choosing where and who will perform your hair transplant is as important a consideration as to what kind of hair transplant to get. Of utmost consideration is that this should be done by the dermatologist /surgeon, and not his/her technician. The surgeon himself/herself should also oversee the design of your hairline and how the extraction of the graft will be done.


3. Hair fibers. The best (and easiest) way to hide a widening part or sparse patch is with hair fibers. They’re tiny, charged fibers that adhere to your scalp (until your next shampoo). Toppik Hair Building Fibers ($25) come in a range of colors so you can easily find one that matches your own hair. (In a pinch, you can also brush a powdered eye shadow that matches your hair color along your part.)
Ms. Imhof, who lives in Land O’Lakes, Fla., was skeptical. The company’s before and after photos seemed too good to be true. But she went for a consultation and made the cut. (Harklinikken’s products are not available to anyone with autoimmune illnesses like alopecia or baldness from scarring, or anyone who is unlikely to see at least a 30 percent increase in growth.)
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Our products are made with high quality ingredients that are non-invasive and 100% safe. Our goal is to provide our customers a hair restoration experience without the negative side effects or increase in health risks in the long term. We are adamant about improving your appearance through the right methods, so you can look good and still maintain great health.
MAX BioPharma, a company working with Hedgehog pathway therapeutics, wants to test its lead compound for hair growth in  mouse model. If data from this experiment turns out to be positive the company says it will reach out to cosmetic or larger pharma partners to commercialize the product. While we currently don’t know how this therapy will fare for hair growth, in the past we have seen impressive potential from stimulators of the Hedgehog pathway.
If you think over-the-counter hair loss shampoos are for you or just want to promote growth and strength, Dr. Schwieger recommends formulas with antioxidants such as vitamin E and ginseng, amino acids, and B-vitamins to help rebuild hair and reduce environmental damage. She cautions against those with parabens, sulfates, and fragrances, which can irritate hair and reduce moisture. Ahead, eight vetted hair loss shampoos to try.
Hair concealers and hair fibers. These are one of the newest cosmetic answers to hair loss. As the name suggests, these products are applied on the scalp or hair to camouflage hair loss and give the appearance of fullness to thinning hair. Some of these are applied directly on the scalp, while others (hair fibers) are attached to the hair, much like hair extensions, to add volume.

Finasteride (Propecia). The drug is recommended for male use only, and is in pill form. The drug basically slows down hair loss, while promoting gradual hair growth. The drug works by stopping the enzyme, type II 5-alpha reductas, which is known to produce DHT. The dosage is one pill a day, and has been found to be effective on 80% of men. Like minoxidil, it works best if the bald patches still have tiny, fine hairs. Results are visible within six to three months, and studies of those who have continued its use for two years show longer, thicker hair than those who used it for only for a short time.
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“I think their effectiveness is not as significant as finasteride or minoxidil,” says Dr. Wolfeld, “however, it’s something that can be used quite easily by patients at home. If they use it two or three times a week, I tell them it can help to thicken their hair.” Results can take up to 18 months to show up, so Dr. Wolfeld stresses that patience is a virtue.
“Re the post 10/17/18 I really liked your response to the request made by one of your readers to email companies asking for information. So I decided to do what you suggested and sent emails to Organ Technologies, Rivertown and Follicum (no particular reason) basically thanking them for their work and wishing them success with their products. Interestingly I received a very nice response from Organ Technologies which really surprised me. Correct me if I’m wrong but I think the sentiment is to be thankful and encouraging to what is being done appose to being negative that we have yet to get what we all want.”
In essence, it is widely known as Microneedling, and it has the power to completely revive your head and scalp from within. It will, among other things, help rejuvenate your scalp skin, help remove old skin cells and embedded oils (sebum) that are currently blocking and clogging your hair follicles, and most of all, it will reactivate the hair follicles in your head to make them grow hairs again. How amazing is that?
Another shampoo which is part of a “system” that includes conditioner and serum. And it’s yet another shampoo which has worked well on its own for many people. The HairGenesis shampoo (and the other products) contains a proprietary formula that is patent-pending, and the company says that the goal of the shampoo is to prepare hair for “maximum growth potential.” It also uses a lot of impressive sounding phrases to describe what the HairGenesis shampoo does.

Like Anderson, he started to lose hair at 21 and tried similarly baroque remedies. “At the time, there was nothing except the snake oil you found at the back of muscle magazines.” He rubbed cayenne pepper into his scalp; he hung upside down; he visited a company that promised a miracle cure that turned out to involve a wig glued on to his head. He looked up a few British trichologists and surmised that trichology was a “study of bullshit” then visited an eminent hair surgeon whose eagerness to perform surgery immediately put him off the idea. It was the discovery of Propecia that ultimately “saved” him. “The drug stopped my hair loss. I had no adverse side effects. I regrew my hair on the crown.”


Anagen is the growth phase. This lasts for about 3 - 5 years, where you can observe your hair growing half an inch every month. Full-length hair from this phase is about 18 - 30 inches long. Studies show that this phase may also be affected by other factors. Asian hair, for example, has been found to have a longer anagen phase. Weather is also a factor; hair growth can be faster in summer than in winter.
The Hair Stimulator is a shampoo from the new, fresh & hip brand Hims. The branding is really on point but let’s dig into the ingredients. Biotin, nettle leaf, tea tree and salicylic acid are the noteables. There’s some evidence to indicate that biotin and salicylic acid reduce scalp DHT levels. Additionally, Hims offers a comprehensive hair loss kit (includes the shampoo) for about $40 bucks a month that gets you hair loss prevention on multiple fronts.
You might be surprised to know that some of those shampoos, conditioners, and styling agents have harsh chemicals that do a number on your hair. You may want to consider switching to softer hair care products that are designed to slow down hair thinning in men. DHT-blocking shampoos and conditioners containing ingredients such as ketoconazole and pyrithione zinc have shown some promise in helping reverse hair loss by potentially disrupting the production of DHT, the hormone linked to male pattern baldness. These
Hair multiplication. Similar to the idea of cloning, this treatment involves taking out donor cells from the hair follicles and then growing and multiplying them in a laboratory. Once sufficient samples have been multiplied, these hair cells are then injected into the bald patches to stimulate hair growth. As a relatively new treatment, hair cloning is still in its research phase.
Pay attention to the foods you eat and how much you’re eating. For example, eating a variety of whole foods that are rich in vitamins and minerals will help fuel your body and the areas responsible for hair regrowth. If you suspect you may be deficient in certain vitamins, visit your doctor to get a blood test and address other dietary issues, such as eating disorders or health conditions that might block nutrient absorption.
What fans say: One user, who has an 11-year-old daughter with severe dandruff, said " I tried multiple OTC shampoos, home remedies, and two prescription scalp treatments. Nothing worked. I really panicked when I noticed a bald spot on her head! A friend suggested Ducray. After two or three shampoos, my daughter’s head was almost clear. I could not believe it. After several weeks of using this shampoo three or four times a week, the chunky flakes are completely gone and her scalp is no longer itchy and red."
However, this partnership ended in 2007 due to potential safety issues since SHH can potentially also cause basal cell carcinoma cancer. P&G was not willing to continue with the drug development work, since even a very minimal risk of developing cancer is not worth it for treating a cosmetic problem such as hair loss (at least in the eyes of government). Interesting comment from the at-the-time CEO of Curis:
Women with androgenic alopecia may consider trying prescription ketoconazole at a strength of 2 percent. This drug comes in the form of a shampoo and also goes by the name Nizoral. It’s an antifungal agent and may help reduce the body’s production of testosterone and other androgens that lead to hair loss. You can also find 1 percent strength at your local pharmacy, but it may not be as effective.
But there is a Canadian company who has been working diligently to change that. And if they’re right—and so far the research indicates they are—baldness may become a thing of the past for those who choose not to tolerate hair loss anymore. And they're not only attacking baldness, Aging skin and tendon degeneration are on the cutting block as well. It's great news for the tens of millions of older Americans who suffer from these malladies. But the most fascinating part lies in the source of the cure. It’s you. The company focuses on the development of cell therapies using a patient's own cells.

The average person loses 50 to 100 hairs per day naturally due to this cycle. But if the process is interrupted at any stage—for example, if the follicle doesn’t come back out of resting mode or starts to shrink—hair loss and hair thinning can result. Interruptions to the cycle can be caused by hormones, stress, poor diet, chemical hair treatments, certain medications, and, of course, good ol' genetics.

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