“Curis (now-dormant company) had performed a lot of studies on targeting the Hedgehog pathway for hair growth with very promising results, however, their compounds caused orthosteric activation of the pathway (turning it on everywhere and robustly which is not safe) vs. Oxy133 which causes a much more regulated and limited allosteric activation of the pathway only in stem cells. This could make Oxy133 a blockbuster. Let’s see what happens.” 
Trichotillomania may be difficult to diagnose if the patient is not forthcoming about pulling at his or her hair. Patients typically present with frontoparietal patches of alopecia that progress posteriorly and may include the eyelashes and eyebrows. Bare patches are typical, and the hair may appear uneven, with twisted or broken off hairs. Trichotillomania may lead to problems with self-esteem and social avoidance. Complications include infection, skin damage, and permanent scarring.18

There have been recent discussions on Italian hair forum websites that indicate the Brotzu lotion may very well be moving ahead and preparing for imminent release. After commenter “Ahmed” brought it to my attention, I went back to check the Bellicapelli forum (the site which had the information on the Brotzu presentation at the Sitri Congress in April). I found a response from user “carlitos71” on this page which seems to display the new theories on the Brotzu lotion.
Hair transplantation involves harvesting follicles from the back of the head that are DHT resistant and transplanting them to bald areas. A surgeon will remove minuscule plugs of skin that contain a few hairs and implant the plugs where the follicles are inactive. Around 15 percent of hairs emerge from the follicle as a single hair, and 15 percent grow in groups of four or five hairs.
As we wait and anticipate the market release of a new hair treatment there may be times when the waiting gets to us and we feel disappointed, frustrated, and even depressed. This is understandable. However, like many other times in life, a simple change of perspective can lift our mood and positively impact how we feel about a situation. When we look at these companies, are we looking at them as commodities? Are they people who owe you something? Or, are they actually rare groups of folks who are working to bring a gift to your life? How often do you really feel grateful to these companies for the work they are doing?

The history and physical examination are often sufficient to determine a specific etiology for hair loss. It is convenient to divide the various causes into focal (patchy) and diffuse etiologies, and proceed accordingly. Patchy hair loss is often due to alopecia areata, tinea capitis, and trichotillomania. Diffuse hair loss is commonly due to telogen or anagen effluvium. Androgenetic alopecia may be diffuse or in a specific pattern, and may progress to complete baldness.
Tinea capitis requires systemic treatment; topical antifungal agents do not penetrate hair follicles. If the causative agent is a Trichophyton species, treatment options include oral terbinafine (Lamisil), itraconazole (Sporanox), fluconazole (Diflucan), and griseofulvin.15 These agents have similar efficacy rates and potential adverse effects, but griseofulvin requires a longer treatment course. Griseofulvin is the preferred treatment for infections caused by Microsporum species, but definitive studies are lacking.15,16 There are limited data about empiric treatment before culture results are available. Because griseofulvin may have lower cure rates in the treatment of T. tonsurans infections, it may not be as effective when used empirically.15 All close contacts of patients with tinea capitis should be examined for signs of infection and treated, if necessary.
Lee Buckler, CEO of Replicel, stated in an interview this week that he expects Shiseido to release clinical trial results in 2018. This is great news that everything is still on track for the anticipated 2018 release of Replicel’s RCH-01 technology in Japan. Lee mentioned “It’s entirely up to Shiseido what they do in regards to this product. There’s certainly a possibility that they could decide if the data is positive, to launch the product in Japan…”. Yes, it seems likely that if the data is positive, Shiseido would go to market with one of the biggest technological breakthroughs of the century. Full interview here. 
Central centrifugal cicatricial (scarring) alopecia: This type of hair loss occurs most often in women of African descent. It begins in the center of the scalp. As it progresses, the hair loss radiates out from the center of the scalp. The affected scalp becomes smooth and shiny. The hair loss can be very slow or rapid. When hair loss occurs quickly, the person may have tingling, burning, pain, or itching on the scalp. Treatment may help the hair re-grow if scarring has not occurred.
It is called the vampire treatment because blood is taken from the patient that removes the platelet rich plasma. Then, the PRP is injected back into the scalp. This energizes the scalp with new active blood flow. Treatment is available at select clinics but widespread adoption may become the norm. It is less invasive than hair transplants but costs more if you count the cost of doing many sessions.
MAX BioPharma, a company working with Hedgehog pathway therapeutics, wants to test its lead compound for hair growth in  mouse model. If data from this experiment turns out to be positive the company says it will reach out to cosmetic or larger pharma partners to commercialize the product. While we currently don’t know how this therapy will fare for hair growth, in the past we have seen impressive potential from stimulators of the Hedgehog pathway.
Things get interesting when we discover a patent which was filed by Sangamo in May 2017 titled “Targeted Treatment of Androgenic Alopecia.” As with virtually all patents, the lengthy text of the patent is difficult to read or to create a concise summary from. An intriguing aspect of this news is Sangamo works in several technology spaces, including previously mentioned genome editing and gene therapy, either would make an advanced type of hair growth therapy we have never seen before. One caveat to mention is the company’s pipeline does not currently display any indication for alopecia, meaning the therapy is not fully developed yet, so it will be some time before trials begin. We certainly hope to hear more from Sangamo Therapeutics as soon as possible about their interesting development for hair growth technology.
But Buckler said hair growth isn’t the only perk to his company’s discovery. It turns out that use in skin repair and tendon regeneration are also possibilities of the technology. “While we were delving deep into the hair follicle, we discovered another cell population,” he said. The hair follicle is actually a minor organ. There are two different cell groupings. One grows hair fibers. Another grows the tissue that the hair follicle fiber grows in.” And it is within this latter cell grouping that the magical main structural protein found in skin and other connective tissues—collagen—is found.
Another shampoo which is part of a “system” that includes conditioner and serum. And it’s yet another shampoo which has worked well on its own for many people. The HairGenesis shampoo (and the other products) contains a proprietary formula that is patent-pending, and the company says that the goal of the shampoo is to prepare hair for “maximum growth potential.” It also uses a lot of impressive sounding phrases to describe what the HairGenesis shampoo does.
It can be safe provided you use registered, regulated healthcare or pharmaceutical services. LloydsPharmacy Online Doctor offers both Propecia and finasteride for men suffering from male pattern baldness through a safe and discreet online prescription service, and you will be able to order minoxidil or Regaine through our online shop or in one of our pharmacy stores.
Certainly a company with a unique background and game plan, HairClone has received some recent media attention. The UK biotech startup was featured in this month’s publication of “Consulting Room” online magazine. In the article both Dr. Bessam Farjo and Paul Kemp of HairClone provided insight as to the company’s current progress and plans for the future. Things seem to be coming along well for HairClone and we should expect to hear from them again within the next several weeks. Full story is on Articles main page.
Because hair concealers work like wigs, choosing one that's right for you is important. More than anything, it should be as natural looking and as subtle as possible. Pick one that matches your natural hair color. Most hair fibers come in nine colors, and if you want to achieve a good color fit, you can blend two colors. Apply first the dark color and then the lighter color.

Contact immunotherapy. Another drug that can be administered for cases of alopecia areata is contact immunotherapy and is recommended for severe cases. Diphenylcyclopropenon (DPCP) is applied on the scalp every week, and the dosage of the drug is increased over time until a mild allergic reaction is observed, which signals that the drug is taking effect. Regrowth may be observed within three months from the beginning of treatment.


Pura d’or also have a hair loss conditioner compliment to this shampoo but we think it’s a bit overkill to use both(as a bottle of this stuff runs on the pricey side)—but if you love the shampoo the conditioner is also a very popular product that couldn’t hurt. Leave it in for about 3 minutes and let your scalp absorb all those vitamins and minerals.


The law enhances the FDA’s ability to modernize clinical trial designs and clinical outcome assessments, which will perhaps speed the development and review of novel medical products, including medical countermeasures. The Cures Act also directs the FDA to create so-called “intercenter institutes” to help coordinate  activities in major disease areas between the drug, biologics and device centers and improves the regulation of combination products. An example of one of these centers is the Oncology Center of Excellence.
Finasteride inhibits an enzyme that converts testosterone to DHT, or dihydrotestosterone, the hormone that causes hair loss in men, and unlike minoxidil, this drug can actually help hair grow back, as well as prevent further loss. All you have to do is take one pill a day, and according to Dr. Evan Rieder, dermatologist in the Ronald O. Perelman Department of Dermatology at NYU Langone Health, two-thirds of men taking this treatment will see improvements in hair density over time. 

“Let’s see, how did it work with Jason?” Farrell said, when I met him, in a sun-drenched suite on the thirty-fourth floor of the Marriott in downtown Manhattan. He was wearing all black: black boots, black-leather bomber jacket, perfectly snug black T-shirt. Tattoos poked out from his jacket sleeves, down to the tops of his hands—black roses and black birds and things. His dark, curly hair bounced past his chin. “I believe he just called up and made an appointment! I don’t consider myself a hair guy to the stars at all. I work with regular people throughout the world.”
MAX BioPharma, a company working with Hedgehog pathway therapeutics, wants to test its lead compound for hair growth in  mouse model. If data from this experiment turns out to be positive the company says it will reach out to cosmetic or larger pharma partners to commercialize the product. While we currently don’t know how this therapy will fare for hair growth, in the past we have seen impressive potential from stimulators of the Hedgehog pathway.
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Cloning has seen many false starts and wrong turns, Christiano told me. Now her team is building “an artificial skin with a dermis and an epidermis, with molds made to mimic the dimensions of hair density,” she explained. “When the artificial skin matures we pull out the pre-formed hairs and insert them into the skin.” Bernstein is convinced that, in the next ten years, cloned hair will happen. “And then the supply and demand problem is solved,” Bernstein said. “Without Bernanke!”
A bathroom covered with loose strands or an ever-scrawnier ponytail can be startling but doesn't necessarily mean anything's wrong. By age 50, half of women will complain of hair loss. "As we age, overall hair density changes and individual strands become finer," says dermatologist Doris J. Day, MD. But just because thinning is natural doesn't mean you have to accept it. Here are 13 solutions to help you keep the hair out of your brush and on your head.
Last fall, the San Francisco startup Hims began a small publicity blitz. Its ads were all over in-boxes and social-media feeds and TV screens; they were even out in real life, on paper placards. Above a picture of a handsome young man with long, luscious dark hair, there was a bold claim: “Thanks to science, baldness is now optional.” Hims, which also sells shampoos and erectile-dysfunction medication, has a minimalist aesthetic, designed by Partners & Spade. (The agency has done work for famed disruptors such as Warby Parker and Casper.) It also has an in-house journal called Savoir Faire. And, within all that attractive packaging and identity branding, the company was very casually offering the holy grail. My latent obsession led me to ask some questions of the ad campaign. It turns out that Hims’s baldness pills are just finasteride, and their topical solution minoxidil. Thanks to expired patents on those products, Hims is able to sell them cheap. And yet ultimately they’re providing the same old solution. Another false prophet.
Treatment for adults with less than 50% of scalp involvement is intralesional triamcinolone acetonide injected intradermally using a 0.5-inch, 30-gauge needle. Maximal volume is 3 mL per session.11 Treatment may be repeated every four to six weeks until resolution or for a maximum of six months. Local adverse effects include transient atrophy and telangiectasia.
Finasteride comes in the form of a tablet and works by inhibiting the formation of DHT, a hormone which permanently damages hair follicles. They are only appropriate for use as a male pattern baldness treatment and must be taken once a day for 3-6 months for the effects to be seen. In one study, 90% of men with mild to moderate hair loss saw positive effects after taking finasteride for six months, with hair loss stopping and in some cases even reversing. Finasteride is therefore very effective while it is being taken, but will not continue to have an effect after treatment has ceased. Around a year after you have finished taking Propecia or finasteride, you can expect your hair loss to have resumed and any hair regrowth to have fallen out. For this reason, they are not cures so much as effective ongoing treatments.
For those of you who only check the Updates page, there was a new Brotzu Check-In article published yesterday. Giovanni Brotzu will be presenting data pertaining to his lotion’s use in androgenetic alopecia at an Italian hair research Congress this Saturday, April 14th. We hope to see photo results from the presentation. Check back to the Brotzu article next week for updates.
However, each formula contains a different mix of ingredients and will act on preventing the hair loss process in a unique way. Perhaps one of the best things about these anti DHT shampoos is that they are mostly natural and organic compositions with little to no side effects. Probably your biggest risk in using one of these shampoos is a red or itchy scalp, which typically goes away after a couple hours following your shower.
While thin hair is nothing to be ashamed of, it's perfectly natural to look for a way to maintain the luscious locks you know and love — and the easiest way to do that is by incorporating the best shampoos for thinning hair into your beauty routine. Whether it's due to stress, hormonal changes, or simply aging, thinning hair and hair loss is something we as women all face at one point or another during our lifetimes. But before we talk about a treatment, let's break down some of the possible reasons behind your thinning hair.
Due to the concern of several readers, I’ve removed the link to the new Trinov website that has popped up on the net. For now, the website only contains an email address subscription box which really poses no issue to anyone who subscribed. At this time, it’s not confirmed who the actual owner of the new Trinov site is, so use your discretion until we find out more regarding this matter. Until more information is known the website will not be shared on Follicle Thought.
Now known as RCH-01, RepliCel’s procedure is a patented cellular replication and implantation technology designed to rejuvenate damaged and miniaturized hair follicles in a balding scalp. According to Buckler, the technology involves the extraction of as few as 20 hair follicles from the back of a patient’s scalp where healthy cycling hair follicles reside.  Specific cells are isolated from hair follicles and are cultured using the company’s proprietary cellular replication process.  The cultured cells are reintroduced or injected back into balding areas on a patient’s scalp and are expected to rejuvenate damaged hair follicles leading to the growth of new healthy hair fibers.
When you notice one or more of these problems, you might be experiencing hair loss. For more information on the different stages of balding, have a look at the Norwood Scale. There, you can see the seven different stages of male pattern baldness. As hair loss progresses higher on the scale it becomes more difficult to keep your hair and potentially regrow lost hair.

Fenugreek. Fenugreek seeds have been found to help in treating hair fall and hair loss. They contain hormones and protein that rebuild the follicles and stimulate growth of hair. Soak a cup of fenugreek seeds in water overnight. Grind it to a paste and apply on your hair. Cover your hair with a shower cap and let it stay for 40 minutes, and then rinse. You can do this every day for a month.

NFL Hall of Fame player Deion Sanders has recently undergone a hair transplant. He has not been shy about discussing it publicly and over the last several weeks has actually continued to put out a slew of hilarious and outrageous posts pertaining to his renewed follicles. For his first announcement to social media, he posted this jubilant and priceless video to his Instagram:

Contact immunotherapy. Another drug that can be administered for cases of alopecia areata is contact immunotherapy and is recommended for severe cases. Diphenylcyclopropenon (DPCP) is applied on the scalp every week, and the dosage of the drug is increased over time until a mild allergic reaction is observed, which signals that the drug is taking effect. Regrowth may be observed within three months from the beginning of treatment.
After the robot was done, two nurses picked off the skin grafts and hairs and put them in petri dishes. While they prepared them for implantation, Bernstein explained the real future of the business: cloning. Bernstein has partnered with a Columbia University geneticist, Angela Christiano, who is working on duplicating hairs. The problem with hair transplantation is that you’re moving hairs around, not creating new ones. Women affected by female-pattern hair loss, in particular, are left out: they don’t have a thick back patch of “donor hair” to work with.
Lee Buckler, CEO of Replicel, stated in an interview this week that he expects Shiseido to release clinical trial results in 2018. This is great news that everything is still on track for the anticipated 2018 release of Replicel’s RCH-01 technology in Japan. Lee mentioned “It’s entirely up to Shiseido what they do in regards to this product. There’s certainly a possibility that they could decide if the data is positive, to launch the product in Japan…”. Yes, it seems likely that if the data is positive, Shiseido would go to market with one of the biggest technological breakthroughs of the century. Full interview here. 
This medication goes by the name Avodart. It is used for the treatment of BPH also known as enlarged prostate. However, there are a large number of users using it for the off label purpose of treating hair loss. Remember the 5 alpha reductase we mentioned that Propecia blocks? Well there are two types of 5 alpha reductase. Type I and Type II. Whereas Propecia has only been shown to block type II, Avodart blocks both types. This effect overall lowers DHT levels even more, further reducing the risk of damaged hair follicles. However, it faces the same limitations as Propecia. It must be taken daily and may lose its effectiveness overtime.
Hair changes about as fast as grass grows, which is to say it’s extraordinarily slow and not visible to anyone checking impatiently in the mirror every day. But during regular follow-up appointments, Harklinikken uses high-tech equipment to photograph and magnify the scalp and count new hairs and active follicles, which motivates users to adhere to the regimen. Too many people give up on treatments like Rogaine and low-level-light devices before they’ve had a chance to work, Dr. Senna said.
Like Anderson, he started to lose hair at 21 and tried similarly baroque remedies. “At the time, there was nothing except the snake oil you found at the back of muscle magazines.” He rubbed cayenne pepper into his scalp; he hung upside down; he visited a company that promised a miracle cure that turned out to involve a wig glued on to his head. He looked up a few British trichologists and surmised that trichology was a “study of bullshit” then visited an eminent hair surgeon whose eagerness to perform surgery immediately put him off the idea. It was the discovery of Propecia that ultimately “saved” him. “The drug stopped my hair loss. I had no adverse side effects. I regrew my hair on the crown.”
David made this claim back in 2000. But fast-forward a few years and his enhanced compensation strategy begins to look a little quaint. Androgenetic alopecia, or male pattern baldness, afflicts about half of all men aged 50 and they can’t all reinvent the sitcom. And significant advances in the £3bn hair regrowth industry mean that they have other, seemingly easier, options. The man who is “ideally bald” (to use Vladimir Nabokov’s description of his comic hero, Pnin) may soon become a rare sight.
Patel said the problem with those treatments is that they have not been subjected to large or head-to-head research. There's great variation in how doctors give the plasma treatments and in laser-based devices, so it's hard for patients to know whether they're getting a proven regimen. Nutrafol seems promising, he said, but he does not think that company-funded research showing its effectiveness has been replicated. He has not recommended it yet.
Harklinikken does not advertise, but the 25-year-old multinational company is beginning an aggressive expansion into the $3.6 billion hair-loss market in the United States, meaning you’re likely to hear a lot more about it. A New York clinic opened in June inside the Core Club in Midtown (you don’t need to be a member to get an appointment); and in August, Harklinikken consultations became available at some 70 Women’s Care Florida obstetrics and gynecology clinics. (Roughly 75 percent of the company’s 50,000 active users are female.)
PolarityTE is a biotech company based in Salt Lake City, UT that kind of launched onto the scene late last year. Shortly after the company was formed it announced that its innovative lead product ‘SkinTE’ would be launching a limited release in several hospitals across the country. The launch of SkinTE came abruptly with no previous clinical trials for the product. This is due to the fact that SkinTE is based on autologous materials, which means they come from a patient and are applied back to the same patient. There is, of course, some manipulation done to the skin sample which is taken from a patient, but the FDA has deemed it to be minor enough not to need lengthy trials to reach the market.

After the groundbreaking 1999 study on mice, some researchers were mildly optimistic that SHH activation could also have positive implications on human hair growth in balding men and women. A new company that was formed in 2000 called Curis partnered with Procter & Gamble in 2005 to try and develop a topical Hedgehog agonist product for scalp hair growth.
Nizoral is the gold-standard in hair loss prevention. Its main ingredient is ketoconazole. The nice thing about Nizoral is that you only need to use it twice a week (because ketoconazole binds to the proteins in your hair so it will keep working many days after use). If you were to use it daily your scalp would be drier than a desert and itchy as all heck.
And just like that, more fascinating hair-related research was published in PLOS Biology. A team of researchers lead by Dr. Nathan Hawkshaw of the University of Manchester have identified the drug ‘WAY-316606’ as a potential candidate for hair regrowth. WAY-316606 is an existing drug used to treat osteoporosis. It’s not clear at this time whether WAY-316606 is approved and on the market, or if it was partially developed to treat the bone disease.
Signage for Shiseido Co. is displayed outside the company's headquarters in Tokyo, Japan, on Friday, Feb. 28, 2014. Shiseido, Japan's largest cosmetics maker, is under reform after posting losses due to weak domestic sales and an impairment loss on goodwill associated with Bare Escentuals, which it bought in 2010. Photographer: Kiyoshi Ota/Bloomberg
The Rogaine rep we spoke to explained that the different packaging (and therefore different prices) has to do with the FDA-approval process: “We discovered in clinical trials that the hair loss patterns between men and women are different,” she said by way of explanation. “Men typically have that bald spot on the crown of their head, where women generally have a general thinning throughout, but concentrated more on the top of the head. So for FDA approval, we had to come up with two different, gender-specific products, so the directions were more explanatory.”
"Despite some of the claims, a shampoo or conditioner won’t be able to stop or slow hair loss, nor help with a receding hairline or thicken hair that’s becoming thinner," says trichologist Anabel Kingsley from The Philip Kingsley Trichology Clinic in London. "At best, a thickening shampoo will make hair temporarily thicker for a short period of time, but they certainly won’t help with hair loss or thinning."
1. Collagen powder. Preliminary studies suggest that marine-sourced collagen may stimulate hair growth, says New York City dermatologist Yoon-Soo Cindy Bae. Though more research is needed, participants in studies reported thicker hair after three to six months of daily use. Crushed Tonic Original Powder ($105) easily mixes into coffee, tea, and water.
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