Lipogaine Big 3 does contain ketoconazole, but only a couple other hair loss/thinning related ingredients. Their Big 5 does not contain ketoconazole, but it does contain a proprietary mix of 17 ingredients for hair loss/thinning. It seems to be a more complete shampoo overall, aside from the hair loss aspects. My initial thought is to go with a combination of Big 5 and Nizoral.
Hair loss is often distressing and can have a significant effect on the patient's quality of life. Patients may present to their family physician first with diffuse or patchy hair loss. Scarring alopecia is best evaluated by a dermatologist. Nonscarring alopecias can be readily diagnosed and treated in the family physician's office. Androgenetic alopecia can be diagnosed clinically and treated with minoxidil. Alopecia areata is diagnosed by typical patches of hair loss and is self-limited. Tinea capitis causes patches of alopecia that may be erythematous and scaly and must be treated systemically. Telogen effluvium is a nonscarring, noninflammatory alopecia of relatively sudden onset caused by physiologic or emotional stress. Once the precipitating cause is removed, the hair typically will regrow. Trichotillomania is an impulse-control disorder; treatment is aimed at controlling the underlying psychiatric condition. Trichorrhexis nodosa occurs when hairs break secondary to trauma and is often a result of hair styling or overuse of hair products. Anagen effluvium is the abnormal diffuse loss of hair during the growth phase caused by an event that impairs the mitotic activity of the hair follicle, most commonly chemotherapy. Physician support is especially important for patients in this situation.
Weinstein has big dark eyebrows and a kind face. Kind of an Elliott Gould vibe. I looked at his head. There was a spotty, thatchy outcropping of gray-black hair. Not exactly an overflowing abundance, but hair, to be sure. “I had nothing on top,” Weinstein said. “You can see—I grew my hair back! And it grew back more or less the color I had when I was young.”
Now known as RCH-01, RepliCel’s procedure is a patented cellular replication and implantation technology designed to rejuvenate damaged and miniaturized hair follicles in a balding scalp. According to Buckler, the technology involves the extraction of as few as 20 hair follicles from the back of a patient’s scalp where healthy cycling hair follicles reside.  Specific cells are isolated from hair follicles and are cultured using the company’s proprietary cellular replication process.  The cultured cells are reintroduced or injected back into balding areas on a patient’s scalp and are expected to rejuvenate damaged hair follicles leading to the growth of new healthy hair fibers.
This is a short-term cure, applied while waiting for hair to grow, and therefore recommended for those with a mild to medium case of hair loss. In addition to being non-invasive, hair concealers and hair fibers are instant and affordable. Like wigs and hairpieces, they are used to effectively cover up balding spots while not getting in the way of growing hair. Compared to wigs, however, they are more natural looking and blend well with your natural hair, therefore drawing less attention when you're out in public.
While some medical practitioners are still on the fence about the effectiveness of laser treatments, studies have found that hair growth using laser therapy increased by 19 normal-size hairs per square centimetre. The regrowth is also observed as thicker, shinier and more manageable. It's a non-invasive, painless procedure that works for both men and women. However, the LLLT is not a stand-alone cure and is thus used in combination with other treatments.
The law enhances the FDA’s ability to modernize clinical trial designs and clinical outcome assessments, which will perhaps speed the development and review of novel medical products, including medical countermeasures. The Cures Act also directs the FDA to create so-called “intercenter institutes” to help coordinate  activities in major disease areas between the drug, biologics and device centers and improves the regulation of combination products. An example of one of these centers is the Oncology Center of Excellence.
The Rogaine rep we spoke to explained that the different packaging (and therefore different prices) has to do with the FDA-approval process: “We discovered in clinical trials that the hair loss patterns between men and women are different,” she said by way of explanation. “Men typically have that bald spot on the crown of their head, where women generally have a general thinning throughout, but concentrated more on the top of the head. So for FDA approval, we had to come up with two different, gender-specific products, so the directions were more explanatory.”
*all photos are models and not actual patients.If you are interested in a prescription product, Hims will assist in setting up a visit for you with an independent physician who will evaluate whether or not you are an appropriate candidate for the prescription product and if appropriate, may write you a prescription for the product which you can fill at the pharmacy of your choice.
Bumble & bumble had fine-haired beauties in mind when creating this super-moisturizing (but still super-weightless) formula. The shampoo’s trifecta relies on damage-controlling panthenol (or you as you may know it, vitamin B5), strengthening wheat protein, and scalp-loving, deep-conditioning aloe vera. Strands are left prepped for big, voluminous blowouts or to be hand-tousled for texture, movement, and shine.
Hair transplant surgery – which works by painstakingly moving grafts of hair (typically two to four follicles at a time) from the back of the head to the temples and crown, the first parts to drop – is becoming mainstream. Wayne Rooney was frank about his 48-hour, £30,000 follicular unit extraction at Harley Street Hair Clinic in 2011, and is widely credited with changing attitudes towards the procedure. Actor James Nesbitt had one as he feared he’d lose out on roles as a bald man. “It was something I struggled with,” he said, “and that was probably the vanity in me.”
Literally jumping right out of the woodwork, the company “HCell” has announced they have been granted an orphan designation from the US FDA for their novel treatment of pediatric alopecia areata. The treatment itself it described as a “topical Injection by regenerating hair through a proprietary blend of commercially procured biologic and autologous tissue.” The company also mentions having a treatment for androgenic alopecia in the works as well. More info to come soon. News release here. 

In 1952, a New York dermatologist named Norman Orentreich invented hair plugs. He removed hair from the back of a patient’s head, where it still grew, and grafted it onto the front. In the decades since, the transplantation process has become more refined. Following the lead of the pioneering dermatologist Robert Bernstein, most doctors perform follicular-unit extraction; instead of crudely ripping up large parts of the scalp, they pluck and move individual follicular units.


I started combining two of them right away – because they both had different ingredients that I really wanted. I combine the Hair Surge for the caffeine, ketoconazole, and saw palmetto, along with the Regenepure DR for the Emu oil. I use a bit of both every day – and though I haven’t noticed a lot of hair coming back in – I HAVE noticed that a whole lot less is falling out. I used to see lots of hair in the tub or in my hand after drying. Hopefully some baby hairs will start so show themselves soon.
It’s also possible that some of Harklinikken’s users are women whose hair would have grown back even if they’d done nothing. Many women who arrive in a dermatologist’s office with prior diagnoses of female pattern hair loss actually have what’s called telogen effluvium. That’s a period of acute shedding of hair — meaning up to 60 percent of hair — three months after a triggering event like pregnancy, significant weight loss or starting or stopping hormone medications.
Minoxidil and oral finasteride are the only treatments currently approved by the U.S. Food and Drug Administration for the treatment of androgenetic alopecia. Both of these drugs stimulate hair regrowth in some men, but are more effective in preventing progression of hair loss. Although there are a number of other treatments listed in various texts, there is not good evidence to support their use.8
Follicum’s origins trace back to 2004, when two Lund University researchers targeting arteriosclerosis stumbled across a modified protein called osteopontin, which grew hair in mice. The researchers knew nothing about the hair-growth industry, but were quickly informed that there were big market demands, especially in Asia. “If you lose hair in Asia, you lose a lot of your credibility,” Jan Alenfall, the C.E.O. of Follicum, said. “This was really a serendipity finding.”
In the initial decade after the first identification of the hedgehog gene around 1980, there was almost no research devoted to the impact of the SHH pathway upon human hair. However, this started to change in the mid-1990s (e.g., this from 1998) and culminated in the seminal work on this subject that was published in the US in 1999: “Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog“.
Patel said the problem with those treatments is that they have not been subjected to large or head-to-head research. There's great variation in how doctors give the plasma treatments and in laser-based devices, so it's hard for patients to know whether they're getting a proven regimen. Nutrafol seems promising, he said, but he does not think that company-funded research showing its effectiveness has been replicated. He has not recommended it yet.
Other medical conditions — most commonly telogen effluvium and seborrheic dermatitis — can also cause hair loss, but most people can trace their follicular woes back to androgenetic alopecia, so we focused our search there. We started with more than 200 products, including all-natural solutions and high-tech gadgets, while skipping treatments that focus only on volumizing or thickening hair. We also limited our scope to the scalp, and left out specialty products designed only for eyebrows or beards.

But in November, after 10 years of research, Rogaine introduced a new 5 percent minoxidil formulation for women. It’s a mousse (instead of a liquid) that needs to be applied only once a day instead of twice, which means that it can be more easily incorporated into a woman’s evening skin-care routine. Teal replaces the blue and silver palette of the men’s Rogaine, and the packaging bears a lotus flower. (Also last year, Pantene introduced its Hair Regrowth Treatment for Women, which is 2 percent minoxidil.)
Dr. Carlos Wesley, a hair restoration surgeon in Manhattan, said that women in his practice respond better to P.R.P. than men do, which may have something to do with the fact that women with genetic hair loss tend to have more inflammatory cells around the follicles. From 2013 to 2014, he said, he had an 83 percent increase in female patients, in part because of P.R.P.
This is an organic shampoo which contains the key ingredient Biotin, often said to topically strengthen existing hair strands. Pura d’Or shampoo also has a proprietary ingredient based on Saw Palmetto, which supposedly blocks DHT – the key culprit in pattern baldness. Some users say it hasn’t just protected their existing hair but has promoted the growth of healthy new hair as well.
Skeptics (among them, Dr. Wesley) are starting to come around after a 2014 randomized double-blind study published in the American Journal of Clinical Dermatology found a “statistically significant” difference in hair density for women who used a laser comb compared with those who used a sham device. (“Comb” is something of a misnomer. The device looks like a hairbrush crossed with a cordless phone; it is glided back and forth across the scalp, roughly a half-inch at a time, usually about 15 minutes three times a week.)
“Everyone wants to try it,” Altman told me. “We get inundated with e-mails saying, ‘Tell me what the price is, I really don’t care, I’ll buy it.’ ” Weinstein looked at me. “You have your hair,” he said. “I don’t know why you’re interested in this,” Altman chimed in, with wildly unrealistic but much appreciated enthusiasm for my reporting. “ ’Cause eighty million people don’t! There’ll be eighty million people reading this article!”

Laser treatments. Low-level laser therapy (LLLT) is used for the prevention and reversal of hair loss. Also known as red light therapy, cold laser, and soft laser, it is a form of light/heat treatment (therefore generally safer) that is used on cases of pattern baldness and alopecia areata. The procedure uses a device that emits light that penetrates into the scalp. The more commonly used lasers are the excimer, helium-neon and fractional erbium-glass. The procedure can increase the blood flow in the scalp to stimulate the follicles that are in resting or dormant phase to go into anagen, and at the same time, prevent the production of DHT, which destroys the hair follicles.

Follicle Thought is pleased to announce a new sponsor of this website, Hair Restoration Laboratories, LLC. The company produces quality anti-DHT shampoo and conditioner products. I have reviewed the ingredients of the shampoo and conditioner and find them to be very thoughtful and well researched. Also important to scalp health, the products contain no sulfates, no parabens, no silicones and no artificial ingredients.  

While thinning generally worsens after menopause, doctors said hormone treatments typically do not improve hair growth. Minoxidil lotion or foam, which can be purchased over the counter, is the first line of treatment. About half of women who use it have not lost more hair a year later, Cotsarelis said. Spironolactone, a blood-pressure drug, can also help, doctors said. Some may also try finasteride — approved to treat baldness in men — off-label. The evidence that it works in women is weak, Patel said.


In the nineteen-forties, a Brooklyn anatomist named James Hamilton studied prisoners in Oklahoma who, having been convicted of sexual assault, were castrated. Hamilton identified testosterone as the root of hair loss, and showed that men castrated before or during puberty did not go bald. He then injected groups of castrated adult men with testosterone and—duly, cruelly—watched their hair fall out.
Finasteride (brand name Propecia) is the closest to a hair loss cure pill that scientists have discovered to date. This is a DHT hair loss cure. DHT is made when 5 alpha reductase converts testosterone, and Propecia has been found to be an effective inhibitor of DHT by preventing this process from happening. It works internally, at the root of the cause. Therefore, DHT sensitive hair follicles in the front and top of the scalp don’t have to fight off nearly as much DHT.

In this section we take a look at current hair loss cures in 2018. Using one or more of the treatments below is your best shot at keeping your hair around. However, if a cure is defined as a permanent fix to an ailment, these are far from that definition. Each of these treatments have their own limitations. Most are seen more as hair loss management treatments, rather than permanent hair loss cures.
Contact immunotherapy. Another drug that can be administered for cases of alopecia areata is contact immunotherapy and is recommended for severe cases. Diphenylcyclopropenon (DPCP) is applied on the scalp every week, and the dosage of the drug is increased over time until a mild allergic reaction is observed, which signals that the drug is taking effect. Regrowth may be observed within three months from the beginning of treatment.

Clearly, minoxidil is not a miracle drug. While it can produce some new growth of fine hair in some — not all — women, it can't restore the full density of the lost hair. It's not a quick fix, either for hair loss in women . You won't see results until you use the drug for at least two months. The effect often peaks at around four months, but it could take longer, so plan on a trial of six to 12 months. If minoxidil works for you, you'll need to keep using it to maintain those results. If you stop, you'll start to lose hair again.
Patel said the problem with those treatments is that they have not been subjected to large or head-to-head research. There's great variation in how doctors give the plasma treatments and in laser-based devices, so it's hard for patients to know whether they're getting a proven regimen. Nutrafol seems promising, he said, but he does not think that company-funded research showing its effectiveness has been replicated. He has not recommended it yet.
Each hair develops from a follicle — a narrow pocket in the skin — and goes through three phases of growth. Anagen (A), the active growth phase, lasts two to seven years. Catagen (), the transition phase, lasts about two weeks. During this phase, the hair shaft moves upward toward the skin's surface, and the dermal papilla (the structure that nourishes cells that give rise to hair) begins to separate from the follicle. Telogen (C), the resting phase, lasts around three months and culminates in the shedding of the hair shaft.
Trichotillomania may be difficult to diagnose if the patient is not forthcoming about pulling at his or her hair. Patients typically present with frontoparietal patches of alopecia that progress posteriorly and may include the eyelashes and eyebrows. Bare patches are typical, and the hair may appear uneven, with twisted or broken off hairs. Trichotillomania may lead to problems with self-esteem and social avoidance. Complications include infection, skin damage, and permanent scarring.18

SOURCES: George Cotsarelis, MD, director, Hair and Scalp Clinic, University of Pennsylvania School of Medicine, Philadelphia. Andrew Kaufman, MD, assistant professor, department of dermatology, University of California, Los Angeles; medical director, Center for Dermatology Care, Thousand Oaks, Calif. Tom Barrows, PhD, director of product development, Aderans Research Institute Inc., Atlanta. Cotsarelis, G. and Millar, S.E. Trends in Molecular Medicine, July 2001; vol 7: pp 293-301. American Society for Dermatologic Surgery web site. American Academy of Facial and Reconstructive Plastic Surgery web site. American Hair Loss Council web site. Springer, K. American Family Physician, July 1, 2003; vol 68: pp 93-102. Hair Loss Help web site, "Interview with Dr. Ken Washenik from Bosley." Fuchs, E. Developmental Cell, July 2001: vol 1: pp 13-25.


A clinician diagnoses female pattern hair loss by taking a medical history and examining the scalp. She or he will observe the pattern of hair loss, check for signs of inflammation or infection, and possibly order blood tests to investigate other possible causes of hair loss, including hyperthyroidism, hypothyroidism, and iron deficiency. Unless there are signs of excess androgen activity (such as menstrual irregularities, acne, and unwanted hair growth), a hormonal evaluation is usually unnecessary.

All that said, our primary consideration for choosing hair loss shampoos for our list was whether it produced actual results. We also acknowledge that what might work for someone may not work for another, but we’re interested in the overall picture. Perhaps not surprisingly, the “big names” in the hair loss game – Lipogaine, Nizoral, etc. – made the grade, in part, because they’ve accumulated years of successful results.
“The most common cause of hair loss in both men and women is androgenetic alopecia, which is genetic pattern hair loss,” explains Dr. Michael B. Wolfeld, a board-certified plastic surgeon and an assistant clinical professor of plastic surgery at the Icahn School of Medicine at Mount Sinai Hospital in New York. The root cause of this type of hair loss is dihydrotestosterone (DHT), a byproduct of testosterone that shrinks certain hair follicles until they eventually stop producing hair.

Managing hair loss is just as important as treating it. Now that we've talked about the different treatment options and cures available to reverse hair loss and promote increased growth, let's talk about how you can manage your condition and at the same time prevent further hair loss. The first is more psychological, while the second is more practical.


I recently published an article covering a story in the press of SkinTE helping to possibly save the life of a burn patient (see Articles). In that post I shared an image from SkinTE’s website which shows an application for hair growth. What some may not be aware of is the fact that Dr. Denver Lough, CEO of PolarityTE, has done some legitimate hair follicle research while at Johns Hopkins University. Whether or not this will increase the chances of a “HairTE” product to become a success, we can’t say. However, it may be of interest to recall two peer reviewed articles that Lough and colleagues published involving the proteins LGR5+ and LGR6+ stem cells and hair growth.
Like the long-suffering friend who inspired her to undergo the procedure, Ms. Telford quickly saw an improvement in her hair. New hair growth usually take at least four months, but at the two-month mark, she has already spotted some baby hairs. “Not a gazillion,” she said, “but it’s a start.” She’s planning to return for follow-up treatments every six months, and has high hopes of ditching the wigs and wearing her hair in a pixie.

Key features: Dr. Zeichner recommends the Keratin Oil Shampoo and Conditioner by OGX for thinning or fine hair that needs the extra strength. This budget-friendly option uses keratin proteins mixed with argan oil to nourish, condition, and strengthen strands, and it's only $16 for the set. The smoothing formula can also increase elasticity for less breakage and split ends.


After the robot was done, two nurses picked off the skin grafts and hairs and put them in petri dishes. While they prepared them for implantation, Bernstein explained the real future of the business: cloning. Bernstein has partnered with a Columbia University geneticist, Angela Christiano, who is working on duplicating hairs. The problem with hair transplantation is that you’re moving hairs around, not creating new ones. Women affected by female-pattern hair loss, in particular, are left out: they don’t have a thick back patch of “donor hair” to work with.
It's for this reason that grocery stores have shelves stocked full with hair care and hair grooming products of all forms and kinds, for different purposes, and even specialized and customized for use of men and women. In one study, it was found that more than half of the men in the UK use about six to ten hair grooming products alone, from the staple shampoos and conditioners to hair gels and other styling products.
It has a very powerful mix of ingredients that addresses many of the known causes of hair loss. Revita contains emu oil and copper peptides, which help your hair follicles absorb the key nutrients in the shampoo. A revision to the product recently removed Ketoconazole, which eliminates dandruff by killing off the fungi that causes it. So if you’re looking for that particular ingredient this will no longer be a good option for you.
Lund, Sweden, March 7, 2018: Follicum AB (“Follicum” or “the company”) today announced that the first patient has been treated in the Phase IIa clinical trial in Germany with its lead candidate FOL-005 on 60 patients with hair loss. The study is conducted at Clinical Research Center for Hair and Skin Science (“CRC”) in Berlin and bioskin, Hamburg, Germany. The global market for pharmaceutical hair loss products for both men and women is estimated to be worth $3 billion. The available drug products have unwanted side-effects that limit their use.

Ms. Imhof, who lives in Land O’Lakes, Fla., was skeptical. The company’s before and after photos seemed too good to be true. But she went for a consultation and made the cut. (Harklinikken’s products are not available to anyone with autoimmune illnesses like alopecia or baldness from scarring, or anyone who is unlikely to see at least a 30 percent increase in growth.)
The pull test may be used to diagnose hair loss conditions.1 The examiner grasps approximately 40 to 60 hairs at their base using the thumb, index, and middle fingers and applies gentle traction away from the scalp. A positive result is when more than 10% of hairs (four to six) are pulled from the scalp; this implies active hair shedding and suggests a diagnosis of telogen effluvium, anagen effluvium, or alopecia areata. However, a negative test result does not necessarily exclude those conditions. The pull test is difficult to standardize because the pulling force is not distributed uniformly and because it is difficult to approximate the number of hairs grasped, thereby leading to false interpretations.
Due to the concern of several readers, I’ve removed the link to the new Trinov website that has popped up on the net. For now, the website only contains an email address subscription box which really poses no issue to anyone who subscribed. At this time, it’s not confirmed who the actual owner of the new Trinov site is, so use your discretion until we find out more regarding this matter. Until more information is known the website will not be shared on Follicle Thought.
Procerin Shampoo for hair loss is part of the Procerin For Men system. Recommended by many doctors and dermatologists it is available over-the-counter without a prescription. Procerin can help reverse hair loss in men suffering from Alopecia Areata and male pattern baldness.  >The Shampoo contains all-natural, powerful DHT blockers that have been tested. Procerin does not use any fillers, preservatives, artificial ingredients or additives. No dangerous or harmful side effects have been reported.  When combined with Procerin Supplement it is our best shampoo for men.
Women’s magazine ‘New Beauty’ recently featured several prospective hair growth therapies in a print article. The feature contains several interesting and worthwhile anecdotes. Check the Articles main page to read about Dr. Cotsarelis’ new research on setipiprant for female alopecia, Histogen’s view on the number of injection sessions which may be necessary to get the most out of HSC, and more.
In this section we take a look at current hair loss cures in 2018. Using one or more of the treatments below is your best shot at keeping your hair around. However, if a cure is defined as a permanent fix to an ailment, these are far from that definition. Each of these treatments have their own limitations. Most are seen more as hair loss management treatments, rather than permanent hair loss cures.
But here's one thing that most people miss when they talk about hair loss: It's part of the natural process of the hair growth cycle. Shedding hair is normal, and losing hair as we age is normal. However, there are instances when we are shedding hair at an abnormally faster rate than usual - and this is something that we have to pay attention to. It's also perfectly understandable and acceptable that some people would like to reverse the hair loss that comes as part of the aging process.
Thanks so much for the guidance! After further research I have to agree with you 100%. Lipogaine Big 3 does containe ketoconazole, which would eliminate the need for Nizoral, however the shampoo only contains a few hair loss/thinning related ingredients. The Big 5 contains 17 and just seems like a better overall product. That plus Nizoral twice weekly seems pretty solid to me.
There are a lot of reasons why your hair may be falling out. It could be hereditary (which you unfortunately can't control), or linked to health- or diet-related changes. Or it could be as simple as the fact that your scalp is stressed by excess buildup—oil, dandruff, multiple days' worth of dry shampoo—that's preventing new hair from growing. Or your strands are (literally) at the breaking point after daily sessions with the flat iron.

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That said, hair loss isn't as bad or as hopeless as it sounds. It shouldn't be cause for added personal stress or social stigma, nor should it be something that should make us feel more self-conscious and less confident as individuals. With the advances in technology, you don't have to be saddled anymore with the uncomfortable choice of wearing an ill-fitting, unnatural-looking hairpiece. There is now a wide array of options available to treat and cure hair loss, whether temporary or permanent.
They recommend using it up to 5 times a week for maximum effectiveness. Using it every day probably wouldn’t be a problem. You mean the Ultrax Labs Hair Solaye conditioner or conditioner in general? The company claims it works in conjunction with the shampoo and judging by the ingredient,s can also help to regrow hair to a small degree. But ketoconazole is way more important compared to other ingredients when it comes to treating hair loss, and the conditioner does not have it, so it’s not as important.
Kerastem, a company developing an autologous fat-derived stem cell therapy for hair growth, has reported positive data from their phase 2 trial. The results have come from a 6 month clinical trial involving 70 patients. In this study, the patients received a one-time injection of fat-derived stem cells, and purified fat, into their scalp. Kerastem reports an average increase of 29 hairs per cm2 from the treatment, or an increase of 17% from baseline. The press release does mention that the treatment “successfully stimulates hair growth in people with early stage hair loss”, so that is something to take into consideration when evaluating the results. For more info visit Kerastem’s website. 
The third and fourth stages are known as telogen and exogen, respectively. In telogen, the hair is supposed to be at "rest" until it finally detaches itself from the follicle and enters the exogen or shedding stage. Once the hair is detached from the follicle, the follicle remains inactive for about three months, after which a new cycle begins again.
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