"We developed a protocol to drive human pluripotent stem cells to differentiate into dermal papilla cells and confirmed their ability to induce hair growth when transplanted into mice," said Prof. Terskikh. The next step in their research is "to transplant human dermal papilla cells derived from human pluripotent stem cells back into human subjects."
Hair changes about as fast as grass grows, which is to say it’s extraordinarily slow and not visible to anyone checking impatiently in the mirror every day. But during regular follow-up appointments, Harklinikken uses high-tech equipment to photograph and magnify the scalp and count new hairs and active follicles, which motivates users to adhere to the regimen. Too many people give up on treatments like Rogaine and low-level-light devices before they’ve had a chance to work, Dr. Senna said.
Minoxidil and oral finasteride are the only treatments currently approved by the U.S. Food and Drug Administration for the treatment of androgenetic alopecia. Both of these drugs stimulate hair regrowth in some men, but are more effective in preventing progression of hair loss. Although there are a number of other treatments listed in various texts, there is not good evidence to support their use.8
This shampoo has one of the top ratings of any shampoo sold online. KIMI Naturals must be doing something right! Saw palmetto, biotin, argan oil, and keratin are some of the highlight ingredients in this shampoo. They offer a 60 day money back guarantee, so if you’re not happy with the results after you give it a go, get you’re money back. On their KIMI Naturals website, they also sell a vitamin supplement and scalp treatment which they sell together with this shampoo as a 3-pack system.

DH—or as it’s less commonly known, Dihydrotestosterone—is the bodily byproduct that (in the TL;DR explanation) shrinks hair follicles until they’re so thin and short they just fall out. Keranique’s unique blend includes a DHT-inhibitor, which penetrates the scalp and follicles to deliver a keratin amino complex, developed to add resilience and protection. This one can contribute to improved texture, healthier strands, and yes, even new growth.


"We developed a protocol to drive human pluripotent stem cells to differentiate into dermal papilla cells and confirmed their ability to induce hair growth when transplanted into mice," said Prof. Terskikh. The next step in their research is "to transplant human dermal papilla cells derived from human pluripotent stem cells back into human subjects."
RepliCel is a regenerative medicine company focused on developing autologous cell therapies (or therapies that involve one individual as both donor and recipient) that address conditions linked to a deficit of healthy cells required for normal healing and function. Located in Vancouver, British Columbia, the company has developed first-of-their-kind cell therapies that will, they hope, treat conditions that now affect 1 in 3 Americans: pattern baldness, aging and sun-damaged skin, and chronic tendon degeneration.
And just like that, more fascinating hair-related research was published in PLOS Biology. A team of researchers lead by Dr. Nathan Hawkshaw of the University of Manchester have identified the drug ‘WAY-316606’ as a potential candidate for hair regrowth. WAY-316606 is an existing drug used to treat osteoporosis. It’s not clear at this time whether WAY-316606 is approved and on the market, or if it was partially developed to treat the bone disease.
Christiano is more of a skeptic. Lab results are nice, she said, but “you can grow mouse or rat hair sixteen ways till Sunday. They grow beautifully!” She laughed. “Humans, not so much.” She points out that there’s so much we still don’t understand. For one: Why does the hair on the back of men’s heads stick around, even when all the rest drops? She also counsels caution when playing God with hair loss. Some companies are seeking hair-restoration cures by attempting to modify developmental-cell pathways. Those pathways, Christiano says, “are potent, and so it’s tempting, but you have to make sure it’s well enough controlled that you don’t initiate a cancer signal.”
The history and physical examination are often sufficient to determine a specific etiology for hair loss. It is convenient to divide the various causes into focal (patchy) and diffuse etiologies, and proceed accordingly. Patchy hair loss is often due to alopecia areata, tinea capitis, and trichotillomania. Diffuse hair loss is commonly due to telogen or anagen effluvium. Androgenetic alopecia may be diffuse or in a specific pattern, and may progress to complete baldness.
DHT blockers and thickening agents combine forces to come to the rescue of hair follicle in dire straights. Good Lab packs this shampoo with just about every ingredient that has any clinical data whatsoever supporting it. Included is their hair boost blend, a patented combination of ingredients to help fight DHT. For it’s full effect, you might want to consider using this shampoo with the Good Lab conditioner and thickening serum.
In Michael Wolff’s “Fire and Fury,” Kuntzman’s theory is bolstered. Wolff writes that Ivanka Trump “often described the mechanics behind it to friends: an absolutely clean pate—a contained island after scalp-reduction ­surgery—surrounded by a furry circle of hair around the sides and front, from which all ends are drawn up to meet in the center and then swept back and secured by a stiffening spray.”
Buckler said it started in 2003 with the academic research of Hoffmann and McElwee at the University of Marburg in Marburg, Germany. At the time they were trying to understand what was happening in the hair follicles of people suffering from androgenetic alopecia—a common form of hair loss in both men and women—or the underlying cause of hair loss.
“While nutritious eating isn’t going to bring your hair back by any means, eating plenty of protein-rich foods and healthy fats can make the hair that you still have look thicker and shinier.” Skimping on the B vitamins in particular can interfere with the formation of hair cells and, therefore, hair growth. The best sources of Bs are protein-packed foods like chicken, fish, eggs, and pork, as well as leafy greens such as spinach. (These foods are also good for melting belly fat, so it’s a win win).
When it comes to organic products there are popular and high-quality brands you can choose from. Some chemicals can have quite harsh effects on longer hair, which means that they are not always suitable for women.  There are several organic brands that can be effective for those sensitive to these chemicals and in some cases can be more effective. Among the organic shampoos available are Reborn MAX and PhytoWorx.  Two brands that use caffeine are Apex Crown from Wick & Strom, and Ultrax Labs Hair Surge.
The follicles on the sides of the scalp are more genetically resistant to DHT, which is why male pattern baldness often results in a “crown” of hair. But its downsides are serious. “With women, finasteride is not an option,” says Dr. Wolfeld. “It’s not FDA-approved for women to take, so we don’t prescribe it.” In fact, due to the drug’s effect on hormone levels, pregnant women are advised to not even touch broken or crushed tablets.
Due to the concern of several readers, I’ve removed the link to the new Trinov website that has popped up on the net. For now, the website only contains an email address subscription box which really poses no issue to anyone who subscribed. At this time, it’s not confirmed who the actual owner of the new Trinov site is, so use your discretion until we find out more regarding this matter. Until more information is known the website will not be shared on Follicle Thought.
The Rogaine rep we spoke to explained that the different packaging (and therefore different prices) has to do with the FDA-approval process: “We discovered in clinical trials that the hair loss patterns between men and women are different,” she said by way of explanation. “Men typically have that bald spot on the crown of their head, where women generally have a general thinning throughout, but concentrated more on the top of the head. So for FDA approval, we had to come up with two different, gender-specific products, so the directions were more explanatory.”
I hope you’re all having a good Friday and feeling good out there. Two weeks ago I posted my first “Feel Good Friday” update which contained a hilarious video of Deion Sanders showing off his new hairline from a 5,000+ FUE procedure he had in 2017. That video is now unable to embed because its owner changed his account to private. Coincidentally, a week after I shared that video I noticed that Deion posted a new video to his own Instagram account of him going back to his clinic for another FUE hair transplant to “comeplete his comeback”, in his own words.
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Scientists from the Indiana University School of Medicine have for the first time created skin with hair follicles using mice stem cells. Research was led by Professor Karl Koehler. The team was able to grow both the epidermis and dermis layers of skin to create a realistic skin model. An interesting quote from Professor Koehler: “It looks like a little ball of pocket lint that floats around in the culture medium. The skin develops as a spherical cyst and then the hair follicles grow outward in all directions – like dandelion seeds.”
When in doubt, read the usage recommendations found on your hair loss shampoo’s container. Those recommendations are there to ensure that you get the best results from your shampoo without causing damage to your scalp or hair. Also, always pay attention to a product’s list of ingredients to make sure that it doesn’t contain something which may cause an allergic reaction.
Blow dryers, flat irons, and other devices: Frequent use of a blow dryer tends to damage hair. The high heat from a blow dryer can boil the water in the hair shaft leaving the hair brittle and prone to breakage. Dermatologists recommend that you allow your hair to air dry. Then style your hair when it is dry. Dermatologists also recommend limiting the use of flat irons (these straighten hair by using high heat) and curling irons.
Women’s magazine ‘New Beauty’ recently featured several prospective hair growth therapies in a print article. The feature contains several interesting and worthwhile anecdotes. Check the Articles main page to read about Dr. Cotsarelis’ new research on setipiprant for female alopecia, Histogen’s view on the number of injection sessions which may be necessary to get the most out of HSC, and more.
But you must start these medical therapies before you lose all your hair. McAndrews likens it to brushing your teeth, in that both are preventative measures. “The sooner you start doing it, the better at slowing down this aging process,” he explains, adding, “Is toothpaste perfect? No, you’re still getting tooth decay with toothpaste, but you’re slowing down tooth decay.”
Dr. Zeichner recommends choosing a shampoo and conditioner that matches the issue you're experiencing. If you have thinning or shedding hair, he says to opt for strengthening products made with keratin or to choose one infused with vitamins and antioxidants, as these can all strengthen strands and create a better environment for your hair follicles to function.
NFL Hall of Fame player Deion Sanders has recently undergone a hair transplant. He has not been shy about discussing it publicly and over the last several weeks has actually continued to put out a slew of hilarious and outrageous posts pertaining to his renewed follicles. For his first announcement to social media, he posted this jubilant and priceless video to his Instagram:
It appears that the gene-editing company Sangamo Therapeutics has an interest in hair growth technology. Sangamo is an interesting company with technology applications in gene therapy, genome editing, cell therapy, and gene regulation. Gene therapy, especially, is at the cutting-edge of medical technology innovation. The company has multiple therapies at phase 1/2 of the clinical trial process for various diseases. 

Hey there, I'm Shawn, the founder of Tools of Men! This site was created to help out other guys by teaching them proper grooming habits and the basics of sensible style. We try to make things here a bit of fun while giving you clear info. If you want to get in touch with us, drop us a line on the contact page or via social media. Thanks for checking out the site - and make sure to come back again!
Key features: Ducray's Kelual Anti-Dandruff shampoo is the best choice for hair loss from severe dandruff or scalp issues. Dr. Zeichner specifically recommended the Ducray brand for soothing inflammation and itchiness on the scalp caused by seborrheic dermatitis. At $28 for a 3.3-ounce bottle, this is a pricier option, but people say the heavy-duty formula really works for severe dandruff.

You’ll find ketoconazole in Nizoral anti-dandruff shampoo, and preliminary research indicates that it may be effective in treating hair loss. Researchers found that both 2% ketoconazole and minoxidil regimens improved hair density, size, and proportion of anagen follicles. Ketoconazole also is effective in treating a fungus called Pityriasis that often inhabits the scalp.
Weinstein has big dark eyebrows and a kind face. Kind of an Elliott Gould vibe. I looked at his head. There was a spotty, thatchy outcropping of gray-black hair. Not exactly an overflowing abundance, but hair, to be sure. “I had nothing on top,” Weinstein said. “You can see—I grew my hair back! And it grew back more or less the color I had when I was young.”
Harklinikken (“hair clinic” in Danish) inspires great loyalty. Four out of five users come as referrals from satisfied customers, said Lars Skjoth, the company’s founder and chief scientist. The results are certainly compelling. After four months of daily application — that is, working the tea-colored tonic into the hair section by section, then letting it sit on the scalp for six hours — most users regain at least 30 percent of lost density, and some as much as 60 percent, according to company figures.
Replicel has secured a key investment and partnership from the YOFOTO Health Industry Co. of China. YOFOTO will be leading clinical trials for Replicel’s tendon repair (RCT-01) and skin rejuvenation (RCS-01) therapies in China. Shiseido maintains the license to use the hair growth therapy (RCH-01) throughout all of Asia. But it’s good news all around as YOFOTO will provide money for Replicel’s continued development. New partnerships are a good sign for Replicel. Next stop is the that Shiseido data, I’m hoping for the best. 🙂
Because there are a lot of products in the crowded marketplace that claim they can regrow your hair, it’s a necessity for the legitimate ones to have disclaimers on their websites. Essentially, these disclaimers state that the products haven’t been evaluated by the FDA and so can’t be guaranteed to provide the benefits they claim to provide—at least not from the standpoint of the regulators.
Minoxidil typically comes in 2% and 5% dosage. With the former, hair growth is not visible up until the fourth month (16 weeks) of use, but it could be faster with the 5% dosage.This is most effective especially if you haven't been bald for more than 5 years, your bald patches are less than 10cm across, and most of all, if the bald spots still have some tiny, fine hairs. Studies found that people who have used minoxidil have observed at least minimal to moderate hair growth. The new hair is typically downy soft, but with continued use, it will grow in thickness as the rest of the hair.
2. Volumizing shampoos and treatments. Typically, these work by depositing ingredients, like wheat protein and keratin, that adhere to the hair shaft to a) thicken it and b) create spaces between hairs so you look like you have more of it. Try Kiehl’s Rice & Wheat Volumizing Shampoo ($18) with hydrolyzed wheat protein; Rogers likes Redken Cerafill Defy Shampoo and Conditioner ($20 each) with ceramides that bulk up hair.

More good research coming from the University of Alabama at Birmingham shows that a certain gene affecting mitochondrial function can dramatically reverse signs of aging in mice. The aging factors which were shown to be reversible include skin wrinkles, gray hair, and hair loss. Next comes the important phase where the researchers continue forward to translate this discovery to human use. Full article on the front page.


Key features: This classic anti-dandruff shampoo by Nizoral uses ketoconazol, an anti-fungal medication, as its main ingredient to treat flaking, scaling, itching, or inflammation caused by seborrheic dermatitis, and is still gentle enough to be used on fine or thinning hair. It's meant to be used just twice a week in between regular shampoos to manage dandruff.
Kerastem, a company developing an autologous fat-derived stem cell therapy for hair growth, has reported positive data from their phase 2 trial. The results have come from a 6 month clinical trial involving 70 patients. In this study, the patients received a one-time injection of fat-derived stem cells, and purified fat, into their scalp. Kerastem reports an average increase of 29 hairs per cm2 from the treatment, or an increase of 17% from baseline. The press release does mention that the treatment “successfully stimulates hair growth in people with early stage hair loss”, so that is something to take into consideration when evaluating the results. For more info visit Kerastem’s website. 

“Let’s see, how did it work with Jason?” Farrell said, when I met him, in a sun-drenched suite on the thirty-fourth floor of the Marriott in downtown Manhattan. He was wearing all black: black boots, black-leather bomber jacket, perfectly snug black T-shirt. Tattoos poked out from his jacket sleeves, down to the tops of his hands—black roses and black birds and things. His dark, curly hair bounced past his chin. “I believe he just called up and made an appointment! I don’t consider myself a hair guy to the stars at all. I work with regular people throughout the world.”
Hair loss is more common than you think and it can happen to anyone. According to Michele J Farber, MD of Schweiger Dermatology Group in NYC, causes range from, “androgenetic or hormone-related hair loss, stress related-hair loss, also called telogen effluvium, and dandruff. Medications, vitamin deficiencies, thyroid disorders, excess styling, and autoimmune disorders can also cause hair loss and thinning.” But the good news is, there are viable solutions, starting with topical growth treatments.

While not a cure for hair loss, this will clear up the muddy waters no doubt. DNA-testing is just starting to be commercially available and by 2020 you’ll be able to count on the likelihood that it will be much more advanced and affordable. Knowing for a fact at an early age whether or not someone will be predisposed to losing their hair will make a huge difference.  This will help that individual be able to plan, budget, and research their options before their hair even begins thinning.


What’s equally frustrating for women is that their hair loss is not as clearly understood as hair loss in men and, according to an article in www.dermentz.org, “..presents itself quite differently from the more recognizable male pattern baldness which usually begins with a receding frontal hairline that progresses to a bald patch on top of the head.” The same article also says that it’s uncommon for women to follow a male pattern unless there is excessive production of androgens in her body.

The main type of hair loss in women is the same as it is men. It's called androgenetic alopecia, or female (or male) pattern hair loss. In men, hair loss usually begins above the temples, and the receding hairline eventually forms a characteristic "M" shape; hair at the top of the head also thins, often progressing to baldness. In women, androgenetic alopecia begins with gradual thinning at the part line, followed by increasing diffuse hair loss radiating from the top of the head. A woman's hairline rarely recedes, and women rarely become bald.
“I think their effectiveness is not as significant as finasteride or minoxidil,” says Dr. Wolfeld, “however, it’s something that can be used quite easily by patients at home. If they use it two or three times a week, I tell them it can help to thicken their hair.” Results can take up to 18 months to show up, so Dr. Wolfeld stresses that patience is a virtue.
In 1952, a New York dermatologist named Norman Orentreich invented hair plugs. He removed hair from the back of a patient’s head, where it still grew, and grafted it onto the front. In the decades since, the transplantation process has become more refined. Following the lead of the pioneering dermatologist Robert Bernstein, most doctors perform follicular-unit extraction; instead of crudely ripping up large parts of the scalp, they pluck and move individual follicular units.

According to practitioners of traditional Chinese medicine, hair health is tied to two things: kidney energy and the blood, which nourish the hair. The solution: acupuncture and Chinese herbs. While there isn't a lot of hard science to back this up, Maureen Conant, a TCM practitioner at Full Bloom Acupuncture in Seattle, says that she's seen women's hair stop falling out and then gradually regenerate after a few months of weekly treatments. 

Dr. Melissa Piliang, a dermatologist at the Cleveland Clinic, said that Rogaine works better on the top and crown (for reasons not fully understood, the frontal hairline tends to be more resistant to treatment) and ideally should be started as soon as women notice thinning. “Any regrowth you get is a minimal amount,” Dr. Piliang said. “So the more density when you start, the better results you get.”
In Vancouver, a Canadian company called RepliCel focusses on the hair follicle’s “dermal-sheath cup cells,” its C.E.O., Lee Buckler, explained. Buckler believes that DHT attacks these cup cells “like a parasite.” Like Histogen, RepliCel’s consumer product would be an injectable. The company would generate new versions of your cup cells, which would be implanted into your “affected area”—the places where your hair has fallen out. Boom: new hairs. (Theoretically.)
But here's one thing that most people miss when they talk about hair loss: It's part of the natural process of the hair growth cycle. Shedding hair is normal, and losing hair as we age is normal. However, there are instances when we are shedding hair at an abnormally faster rate than usual - and this is something that we have to pay attention to. It's also perfectly understandable and acceptable that some people would like to reverse the hair loss that comes as part of the aging process.
A few studies support the use of red ginseng, sometimes called panax ginseng (about $25), for hair regrowth. It can have an anti-apoptotic effect on the hair, Rogers says, meaning it slows cell death so hair follicles can grow for a longer period of time. But before taking any of these supplements, it’s important to consult your doctor; a lab test can confirm whether you need a particular supplement or if taking it will just be a waste of time and money.

NIZORAL???? What? Are u joking 🙃? NIZORAL make you loose hair , NIZORAL is not á shampoo is a synthetic imidazole antifungal drug used primarily to treat fungal infections. Ketoconazole is sold commercially as a tablet for oral administration (although this use has been discontinued in a number of countries), and in a variety of formulations for topical administration, such as creams (used to treat tinea; cutaneous candidiasis, including candidal paronychia; and pityriasis versicolor) and shampoos (used primarily to treat dandruff—seborrhoeic dermatitis of the scalp).
I started combining two of them right away – because they both had different ingredients that I really wanted. I combine the Hair Surge for the caffeine, ketoconazole, and saw palmetto, along with the Regenepure DR for the Emu oil. I use a bit of both every day – and though I haven’t noticed a lot of hair coming back in – I HAVE noticed that a whole lot less is falling out. I used to see lots of hair in the tub or in my hand after drying. Hopefully some baby hairs will start so show themselves soon.

"Firstly, even the very good ones won’t get to the root of the issue - pardon the pun - and prevent or treat male or female pattern baldness which is caused by genetics, nor deal with hormonal issues at the heart of female hair loss. But they can help make the hair you do have stronger and healthier. And they can be useful in putting a hair loss regime in place, along with medication like Minoxidil or Finasteride and/ or a hair transplant.
“The most common cause of hair loss in both men and women is androgenetic alopecia, which is genetic pattern hair loss,” explains Dr. Michael B. Wolfeld, a board-certified plastic surgeon and an assistant clinical professor of plastic surgery at the Icahn School of Medicine at Mount Sinai Hospital in New York. The root cause of this type of hair loss is dihydrotestosterone (DHT), a byproduct of testosterone that shrinks certain hair follicles until they eventually stop producing hair.
"The majority of men lose their hair not through stress, or bad diet, or lack of sleep, but through the genetic trait of male pattern baldness which is hard to treat through shampoos or supplements alone. Women lose their hair for very different reasons, but the argument still stands that a lot of the hair loss products on the market are just offering false hope. That said, there are a few that really work."

Yesterday marked the “estimated study completion date” for setipiprant’s phase 2a trial in androgenetic alopecia in males. The participants of the trial received 1000 mg of setipiprant by oral tablets twice a day over a 6 month period. I expect the results to be presented sometime in 2nd half 2018. Here’s to hoping for positive results from this trial and expediency in beginning a phase 2b or phase 3 trial for setipiprant. Clinical trial page here.
Other therapies for the treatment of alopecia areata include topical mid- to high-potency corticosteroids, minoxidil, anthralin, immunotherapy (diphenylcyclopropenone, squaric acid dibutylester), and systemic corticosteroids.12 Currently available therapies often yield unsatisfactory results, and some clinicians rely on the high rate of spontaneous remission or recommend a hairpiece or wig if remission does not occur.13
If you do decide to start treatment to save your hair, a good place to start is with minoxidil, more commonly known as Rogaine. Don’t expect this hair-loss treatment to create luscious locks; minoxidil is better at slowing down or preventing more loss rather than promoting hair growth. But, according to Dr. Amy McMichael, professor and chair of Wake Forest Baptist Medical Center’s Department of Dermatology, it is effective “if used as recommended, with evidence of improvement seen around six to nine months.” Simply massage the foam or solution into your scalp once or twice daily, and for best results, use a formula with 5 percent concentration.
With those pinned down, it wasn’t hard to determine which don’t actually work. Pretty much all the “active” ingredients listed in ineffective treatments — from biotin and zinc to emu oil and saw palmetto — have never been proven, and are instead marketed based on logical-seeming correlations. It would make sense that biotin, a B vitamin readily found in hair, skin, and nails, could help hair grow more quickly. And caffeine is a stimulant that works in coffee, so rubbing some on your scalp might wake some of those sleepy follicles… right?
And, for all of these collective efforts, Christiano reminded me, the only things that have really worked were discovered accidentally. Soon to join minoxidil and finasteride will be Xeljanz, or tofacitinib: originally developed for rheumatoid arthritis, it has remarkable effects on hair growth for patients with alopecia areata, an autoimmune disorder that causes patients to lose hair in big patches over their entire bodies.
Due to the concern of several readers, I’ve removed the link to the new Trinov website that has popped up on the net. For now, the website only contains an email address subscription box which really poses no issue to anyone who subscribed. At this time, it’s not confirmed who the actual owner of the new Trinov site is, so use your discretion until we find out more regarding this matter. Until more information is known the website will not be shared on Follicle Thought.
Key features: Dr. Zeichner recommends the Keratin Oil Shampoo and Conditioner by OGX for thinning or fine hair that needs the extra strength. This budget-friendly option uses keratin proteins mixed with argan oil to nourish, condition, and strengthen strands, and it's only $16 for the set. The smoothing formula can also increase elasticity for less breakage and split ends.
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