Women’s magazine ‘New Beauty’ recently featured several prospective hair growth therapies in a print article. The feature contains several interesting and worthwhile anecdotes. Check the Articles main page to read about Dr. Cotsarelis’ new research on setipiprant for female alopecia, Histogen’s view on the number of injection sessions which may be necessary to get the most out of HSC, and more.
Finally, if these tests come back normal, your dermatologist may suggest a scalp biopsy of a couple of two-millimeter sections taken from your scalp under local anesthesia ($400 and up). It can determine whether genetic hair loss, telogen effluvium (a condition in which hair falls out from stress or rapid weight gain), or a disease (such as lupus) is the cause of your shedding, and your dermatologist can treat you accordingly.

I asked Joseph what it might feel like to get his hands on an actual, proven hair-growth product. The question gave him pause. “It’s hard to put into words,” he said. “This would be the biggest, freeing, liberating thing for so many people. I mean, there would be smiles from coast to coast. That’s the best way I can respond to that question. I think people would be smiling from coast to coast.”


Hair loss can be devastating to many men, but perhaps even more so for women, who have often suffered in silence. But, fact is, women make up nearly 40 percent of hair-loss sufferers in the United States. The psychological damage associated with hair loss is, for many women, extensive, especially in a society where hair-loss in men – though usually unwanted – is more or less an accepted fact of life.
There have also been studies on the effects of 1% pyrithione zinc shampoo and a 5% minoxidil solution. In one study, 200 men between the ages of 18 to 49 who experienced baldness between type III and type IV on the Norwood scale were given this treatment for a six-month period. They found that minoxidil, when used on its own, was approximately twice as powerful as pyrithione zinc at stimulating hair growth, but that both products were successful at increasing the amount of visible hair when used over a 26-week period.
It’s also possible that some of Harklinikken’s users are women whose hair would have grown back even if they’d done nothing. Many women who arrive in a dermatologist’s office with prior diagnoses of female pattern hair loss actually have what’s called telogen effluvium. That’s a period of acute shedding of hair — meaning up to 60 percent of hair — three months after a triggering event like pregnancy, significant weight loss or starting or stopping hormone medications.
This particular research which was published in the Nature journal showed that a synthetic version of sandalwood, called Sandalore, binds to the OR2AT4 receptor in hair folliles and prolongs their anagen (growth) phase. The hair follicles studied were treated in a petri dish. Paus has subsequently announced that a completed clinical trial of 20 female volunteers using a topical version of Sandalore showed a reduction of daily hair loss. There is also another larger clinical trial ongoing now which hopes to confirm the effect and announce results in early 2019. Paus has gone as far to say “there is even a chance that this might be able to bring the hair back.” We’ll keep our fingers crossed.

Other options include microneedling ($1,200 and up per treatment) and platelet-replacement therapy (also $1,200 and up per treatment), which are usually offered in conjunction. Your scalp will be numbed first so you don’t feel the pinpricks involved in microneedling. They promote hair regeneration by spurring wound healing, and platelet-replacement therapy involves injecting growth factors into those wounds. “Combination therapy typically works better than monotherapy and usually yields results after three monthly treatments,” says Sadick, and should be teamed with an at-home minoxidil treatment.
When you're investing considerable time and money on a mix of hair treatments and cures, the last things you should be doing are those that will only aggravate your condition. Likewise, when your hair has finally grown back, the last thing you would want is for you to go through another horrific episode of hair loss. Preventing further - or another case of hair loss, and stopping it before it actually happens should be your goal.
Besides cost considerations, a hair transplant is generally prescribed as a last resort for permanent hair loss problems. It is also not allowed for people under the age of 25, those with a continuing problem of hair loss, as well as those with other health conditions like uncontrolled diabetes, serious heart problems and hypertension. Patients whose hair loss is caused by other factors, such as a skin or scalp disorder or who suffer from a psychological condition that causes them to pull at their hair are not recommended for this procedure. Since the procedure requires taking a sample from the back of the head, those who do not have enough follicles from this section that can be used for transplant are not also eligible.
A clinical researcher who has spent decades researching the fields of pattern hair loss, alopecia areata, endocrinology of the hair follicle and hair follicle morphogenesis, Hoffmann works in his private practice, as a teaching professor in the Department of Dermatology at the University of Marburg and as a researcher on histopathology on hair diseases. He has participated in dozens of clinical hair studies and is the inventor of TrichoScan®, a computerized technique to measure hair growth.
Alexey Terskikh PhD of Sanford Burnham Prebys research institute has news to share about his hair follicle research. The Articles page gives you all the highlights on what advancements Terskikh has made over the past three years and when he is planning to take his cloning method to FDA human trials. This is one example of a peer reviewed journal article which actually developed to human translation in a timely manner. Happy Friday
Key features: This sage shampoo and tea tree conditioner set by Maple Holistics is full of good-for-you nutrients. The shampoo is made with Argan oil, green tea, and jojoba oil, and includes anti-fungal ingredients that are effective at soothing inflammation and fighting dandruff caused by yeast. The conditioner is infused with keratin and vitamin b5 for repairing, moisturizing, and strengthening strands, as recommended by Dr. Zeichner. This option is also sulfate- and paraben-free, making it a great option for color-treated and fine hair.

Laser devices: Brushes, combs, and other hand-held devices that emit laser light might stimulate hair growth. These devices might make hair look more youthful in some people. Because the FDA classifies these products as medical devices, the products do not undergo the rigorous testing that medicines undergo. The long-term effectiveness and safety for these devices are not known.


“Re the post 10/17/18 I really liked your response to the request made by one of your readers to email companies asking for information. So I decided to do what you suggested and sent emails to Organ Technologies, Rivertown and Follicum (no particular reason) basically thanking them for their work and wishing them success with their products. Interestingly I received a very nice response from Organ Technologies which really surprised me. Correct me if I’m wrong but I think the sentiment is to be thankful and encouraging to what is being done appose to being negative that we have yet to get what we all want.”
Sadick suggests avoiding “products with dyes and preservatives, like parabens and synthetic fragrances.” Ingredients that thicken the hair include amino acids, biotin, ginseng root, and menthol or peppermint oil — these are what you want to look for. “Amino acids provide the building blocks to build new strands, while biotin, part of the B-vitamin complex, is required by hair to metabolize amino acids and can help strengthen hair,” Sadick says. “Antioxidants such as vitamin E and ginseng are beneficial to promote hair growth because they reduce free radicals from sun, stress, or overprocessing and have anti-inflammatory properties.” Last but not least are the botanicals, which are great as they are rich in antioxidants and other compounds that stimulate blood flow and promote hair growth.
A diet that is poor or lacking in certain nutrients, particularly iron, protein, and vitamin B, which are essential in the production of keratin, can cause a long telogen phase and a very short anagen stage. On the other hand, excess supply of vitamin A in the body, especially those taken through supplements, can prove to be toxic and can cause a range of adverse body effects including loss of appetite, fatigue and consequently, hair loss.
In the nineteen-forties, a Brooklyn anatomist named James Hamilton studied prisoners in Oklahoma who, having been convicted of sexual assault, were castrated. Hamilton identified testosterone as the root of hair loss, and showed that men castrated before or during puberty did not go bald. He then injected groups of castrated adult men with testosterone and—duly, cruelly—watched their hair fall out.
Drugs normally used for rheumatoid arthritis and bone marrow cancer, they are now being studied for their uses as a hair growth medicine. These are a new class of medicines labeled as JAK inhibitors. In one study, 6 out of 9 patients dramatically went from bald to a full head of hair after taking Ruxolitinib for 5 months. In another study several subjects were able to regrow full heads of hair. Unfortunately, sustained use of such drugs will have severe side effects. Many of these concerns would be side stepped if a topical formula could be developed. Researchers at the Department of Dermatology and Genetics and Development at Columbia University Medical center are now studying other JAK inhibitors in placebo controlled studies.
 For hair transplant clinics, this is the ultimate goal. Bald people would make a mad dash to their clinics to get their new heads of hair. Since the main limitation of hair transplantation surgery is how many hairs can be harvested from the back of the scalp before it appears thin, stem cloning (the growing of dermal papilla cells) will solve that problem in totality. Recent research that has taken place in California has taken a big step toward the cure for hair loss. 

And just like that, more fascinating hair-related research was published in PLOS Biology. A team of researchers lead by Dr. Nathan Hawkshaw of the University of Manchester have identified the drug ‘WAY-316606’ as a potential candidate for hair regrowth. WAY-316606 is an existing drug used to treat osteoporosis. It’s not clear at this time whether WAY-316606 is approved and on the market, or if it was partially developed to treat the bone disease.
The most common form of hair loss is androgenetic alopecia, or, in other words, male or female pattern baldness or hair loss. Androgenetic alopecia is genetic and affects an estimated 50 million men and 30 million women in the United States. Among white women in the U.S., an average of 19% are affected by female pattern hair loss, but that percentage increases with age. The prevalence is nearly doubled in Australia at 32% and much lower in Korea and China at < 6%. As of 2015, no studies had been done on the prevalence of female pattern hair loss in Brazil or Africa.

Retin-A, or topical tretinoin, is sometimes used as a combination therapy with minoxidil for androgenic alopecia. It’s important to use this type of medication under the guidance of your doctor. In some circumstances, tretinoin can actually cause hair loss. Some people who have used it at home report that topical retinol creams, serums, and lotions may make hair loss worse.


One of the longest running companies in the hair growth industry, Histogen, has been granted an IND from the US FDA for the use of its growth factor biologic (HSC) in female androgenic alopecia. The product will be called “HSC660” for use in women. IND stands for ‘investigational new drug’, and is a necessary permit that companies must obtain before starting clinical trials with a new medicinal substance. 
Finally, if these tests come back normal, your dermatologist may suggest a scalp biopsy of a couple of two-millimeter sections taken from your scalp under local anesthesia ($400 and up). It can determine whether genetic hair loss, telogen effluvium (a condition in which hair falls out from stress or rapid weight gain), or a disease (such as lupus) is the cause of your shedding, and your dermatologist can treat you accordingly.
The trick about all of these hair-loss products and treatments is that they’ll stop working as soon as you stop using them. “They have to be ready for a lifetime commitment,” says Rieder. But, just like brushing your teeth, as long you keep on keeping on with the scientifically proven preventative treatments, those hairs on your head should be just fine.
The cause of female-pattern hair loss is unknown, but doctors said there is a strong genetic component. The risk can come from male or female relatives. Though it looks as if the hair is falling out, that's not really what's happening. Cotsarelis said hair follicles are becoming smaller and producing hairs that may be so small that you can't see them.  Women tend to retain more normal, thick hairs than balding men do. 

I started combining two of them right away – because they both had different ingredients that I really wanted. I combine the Hair Surge for the caffeine, ketoconazole, and saw palmetto, along with the Regenepure DR for the Emu oil. I use a bit of both every day – and though I haven’t noticed a lot of hair coming back in – I HAVE noticed that a whole lot less is falling out. I used to see lots of hair in the tub or in my hand after drying. Hopefully some baby hairs will start so show themselves soon.
Jimenez, J. J., Wikramanayake, T. C., Bergfeld, W., Hordinsky, M., Hickman, J. G., Hamblin, M. R., & Schachner, L. A. (2014). Efficacy and Safety of a Low-level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-controlled, Double-blind Study. American Journal of Clinical Dermatology, 15(2), 115–127.

However, the high incidence of androgenic alopecia is caused by the male hormones. Testosterone in the scalp is converted into dihydrotestosterone (DHT) that causes the follicles to shrink in size, therefore inhibiting the growth of hair, which eventually leads to baldness. However, hair follicles on the sides and back of the head do not have as much DHT compared to the top, hence why hair loss is concentrated on the crown of the head. Interestingly, DHT is known to help in the growth of the beard and hair on the chest, a reason why most bald men have hairy chests and grow their beards much faster.
I started combining two of them right away – because they both had different ingredients that I really wanted. I combine the Hair Surge for the caffeine, ketoconazole, and saw palmetto, along with the Regenepure DR for the Emu oil. I use a bit of both every day – and though I haven’t noticed a lot of hair coming back in – I HAVE noticed that a whole lot less is falling out. I used to see lots of hair in the tub or in my hand after drying. Hopefully some baby hairs will start so show themselves soon.
Follicle Thought is pleased to announce a new sponsor of this website, Hair Restoration Laboratories, LLC. The company produces quality anti-DHT shampoo and conditioner products. I have reviewed the ingredients of the shampoo and conditioner and find them to be very thoughtful and well researched. Also important to scalp health, the products contain no sulfates, no parabens, no silicones and no artificial ingredients. 
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Key features: Dr. Zeichner recommends the Keratin Oil Shampoo and Conditioner by OGX for thinning or fine hair that needs the extra strength. This budget-friendly option uses keratin proteins mixed with argan oil to nourish, condition, and strengthen strands, and it's only $16 for the set. The smoothing formula can also increase elasticity for less breakage and split ends.

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