As we wait and anticipate the market release of a new hair treatment there may be times when the waiting gets to us and we feel disappointed, frustrated, and even depressed. This is understandable. However, like many other times in life, a simple change of perspective can lift our mood and positively impact how we feel about a situation. When we look at these companies, are we looking at them as commodities? Are they people who owe you something? Or, are they actually rare groups of folks who are working to bring a gift to your life? How often do you really feel grateful to these companies for the work they are doing?
I hope you’re all having a good Friday and feeling good out there. Two weeks ago I posted my first “Feel Good Friday” update which contained a hilarious video of Deion Sanders showing off his new hairline from a 5,000+ FUE procedure he had in 2017. That video is now unable to embed because its owner changed his account to private. Coincidentally, a week after I shared that video I noticed that Deion posted a new video to his own Instagram account of him going back to his clinic for another FUE hair transplant to “comeplete his comeback”, in his own words.
Originally spotted this on HairLossCure100’s twitter page. Concert Pharmaceutical’s therapy for alopecia areata, CTP-543, has been granted fast track designation from the FDA. CTP-543 is an oral JAK inhibitor (ruxolitinib). From what I’ve read, fast track designation encourages early and frequent communications between the FDA and the company during the development process to ensure issues and questions are resolved quickly.
More good research coming from the University of Alabama at Birmingham shows that a certain gene affecting mitochondrial function can dramatically reverse signs of aging in mice. The aging factors which were shown to be reversible include skin wrinkles, gray hair, and hair loss. Next comes the important phase where the researchers continue forward to translate this discovery to human use. Full article on the front page.
You always hear these stories about people who take a homeopathic approach to fighting baldness. It’s always some off-the-wall remedy like smearing a paste of ginger and cayenne pepper on your scalp three times a day or eating a special type of ginseng farmed only in a rural village in Tibet. We'll go on the record to say that it's highly unlikely that these remedies work at any level.
In our research and our conversations with experts, one name kept popping up repeatedly: Rogaine. As the first topical brand FDA-approved to help regrow hair (all the way back in 1988), Rogaine benefits from more than 20 years of clinical trials and consumer feedback. Rogaine was the first brand to offer a 5 percent minoxidil foam solution when it debuted Men’s Rogaine Unscented Foam in 2006, and virtually every treatment developed since (for both men and women) has been an imitation or derivation of that formula.
A DHT Blocker Shampoo is any shampoo formula that contains known DHT inhibiting agents. DHT inhibiting agents usually act by preventing 5 alpha reductase from converting testosterone to dihydrotestosterone (DHT). Leading research agrees that DHT is the foremost cause of hair loss. DHT binds to sensitive hair follicles causing them to shrink and eventually to stop producing hair altogether.

According to the press release, a fast track designation is “intended to facilitate the development of new therapies for serious conditions and with the potential to address an unmet medical need. A company with an investigational medicine receiving Fast Track designation may be eligible for more frequent communications with the FDA and may receive an expedited review of the new drug application.”


Originally spotted this on HairLossCure100’s twitter page. Concert Pharmaceutical’s therapy for alopecia areata, CTP-543, has been granted fast track designation from the FDA. CTP-543 is an oral JAK inhibitor (ruxolitinib). From what I’ve read, fast track designation encourages early and frequent communications between the FDA and the company during the development process to ensure issues and questions are resolved quickly.

Hair loss is something that affects a huge proportion of men, and yet unfortunately there is no cure. Though you may have heard of certain medicines such as Propecia (finasteride) or Regaine (minoxidil), it is far more accurate to think of these medicines as effective long-term treatments. There are interesting experimental options being trialled currently, yet these established treatments can be effective at preventing hair loss in up to 90% of men.
The answer, to be brutally honest, is no. Combine that with the fact that many shampoo manufacturers are hungry for a quick buck and make false claims about ingredients that haven’t been proven to work, and you have a market that can be treacherous to navigate. There are even fake reviews – which is a whole additional layer of deceit when you think about it.
Researchers from South Korea have identified a new peptide called PTD-DBM which exhibits wound healing and hair regeneration effects in preclinical studies. The research is being led by Professor Kang-Yell Choi of Yonsei University. Choi’s team identified the peptide PTD-DBM which targets a protein called CXXC5. The interaction of these two proteins leads to stimulation of the Wnt pathway, which then initiates hair follicle neogenesis. Choi hopes to develop this peptide further into a potential hair growth drug candidate. A research paper about these findings was put out by the team earlier this year. Source article about this development here.
The Holy Grail remains a drug that will promote regrowth, but this might not be so far away. Earlier this year, Manchester University announced that an osteoporosis drug had been found to have “dramatic results” promoting hair growth when applied to tissue samples in pre-clinical trials. The resultant frenzy left the PhD student responsible, Dr Nathan Hawkshaw, a little dazed. “Every other week, something comes out about hair loss and it doesn’t generate as much media coverage as what I experienced,” he grumbles. He’s in this for the science – there aren’t many fields where you get to mess around with real human tissue – but such is the distress caused by hair loss and such is the potential customer base that interest is always high.

Pattern balding is most common among middle-aged men, but signs can actually begin as early as the mid-20s. Once the hair loss starts, it generally takes about 15-25 years for most men with this condition to lose most of their hair. In some cases though, the progression of the condition can be fast so that others are already completely bald in just five years.
We’re not exactly sure about that “growth potential” stuff; for our purposes, the question is whether the product works to stop hair loss. Several of the confusing phrases the company uses actually address that question. The shampoo works to protect mitochondrial DNA, an important component in protecting and growing hair follicles, with fatty acids. It also contains ingredients which prevent further damage to the follicles. In other words, it protects and strengthens the hair you already have.
I just received an email sharing a new Trinov website: TrinovAnticaduta.com. This one does appear to be an official website for Trinov. The page is in Italian and can be translated, it mainly features a sign up form to download the “Trinov ebook” for either the men or women’s version. I downloaded the men’s Trinov ebook, however it is a pdf in the Italian language and cannot be translated. There is also a short YouTube video for Trinov featured on the page. Fidia Pharma’s logo is at the  bottom of the TrinovAnticaduta page and for good measure I looked up the domain on Whois and saw that the page is registered to Fidia. Things will just keep getting more interesting from here.
Thank you so much for responding, Domen! Another question after further research this weekend. – have you heard of/used/reviewed a product called Regenepure,? The shampoo contains 1% ketoconazole and is the same price as Lipogaine, Used every day, that would seem to eliminate the need for adding Nizoral to the weekly regimen. Curious to hear what you know about that product. Thanks again!!!
While thinning generally worsens after menopause, doctors said hormone treatments typically do not improve hair growth. Minoxidil lotion or foam, which can be purchased over the counter, is the first line of treatment. About half of women who use it have not lost more hair a year later, Cotsarelis said. Spironolactone, a blood-pressure drug, can also help, doctors said. Some may also try finasteride — approved to treat baldness in men — off-label. The evidence that it works in women is weak, Patel said.
HairMax is known for their lasercomb products — an FDA approved hair loss treatment. They’ve started to branch out and now they offer a supplement, topical, and this shampoo (as well as a matching conditioner). One of the standout ingredients in this shampoo is the gotu kola. We have a full write up about gotu kola and its relationship to hair loss here.
Please help. My hair has always been my pride and joy. I figured since it is pretty damn healthy, it could deal with some bleach damage. And I figured the master stylist who did all the color-corrections would know how much would be too much. I was wrong, and now I want to burst into tears every time I look at my hair or touch it. I just don’t know what to do. my hair has also NEVER been shorter than this and it breaks and falls out. What should i do to regrow hair?
Over the past year, the Hair Restoration Laboratories’ Professional Strength DHT Blocking Hair Loss Shampoo (and accompanying DHT Blocking Hair Loss Conditioner) has been a top seller on Amazon and many other sites. Combined, the daily use Shampoo and Conditioner has more DHT blockers than any shampoo/conditioner set presently available. Among the key DHT Blockers in this set are: Caffeine, Saw Palmetto, Black Cumin Seed Oil, Cayenne Fruit Extract, Rosemary Leaf Oil, Pumpkin Seed Oil, Green Tea Leaf Extract, Pea Extract and many more. By helping to block DHT, they should be a great asset in helping to halt the miniaturization of the hair follicles and regrow healthier and thicker hair.
"Others are taking hair follicles out of human scalp and growing them with dermal papilla cells," Cotsarelis says. "If they grow in culture, you might be able to recombine them with skin cells and form new follicles. This would let you expand the number of follicles you get for a hair transplant. This may not be that far off -- five to 10 years, maybe. There's very good evidence you will be able to do that."
Due to the concern of several readers, I’ve removed the link to the new Trinov website that has popped up on the net. For now, the website only contains an email address subscription box which really poses no issue to anyone who subscribed. At this time, it’s not confirmed who the actual owner of the new Trinov site is, so use your discretion until we find out more regarding this matter. Until more information is known the website will not be shared on Follicle Thought.

We've heard it all before: clients waking up one day in shock after discovering a coin-sized bald spot on their heads; women agonizing over the strands of hair they see on the shower floor; men looking for topical creams and shampoos to prevent the early onset of balding. Even more are tales of men and women on the search for the perfect wig or toupee to cover up the loss of their hair as a result of medication for a chronic illness.


One of the downsides to the product is that you pay hand over foot for all those special ingredients DS packed into this bottle. It’s not the cheap crap that most manufacturers throw into your standard shampoos. It is expensive stuff, and using it daily means there’s no real way of making it last a long time either. The bottom line is you have to bite the bullet but with all the ingredients in this bottle, you’re getting your money’s worth.
2. Pyrithione zinc shampoo. Traditional volumizing shampoos will give the hair you have a lift so it looks fuller (we like the sulfate-free L’Oréal Paris EverPure Volume Shampoo, $8). But some research suggests shampoos with the antidandruff ingredient zinc pyrithione can mitigate hair loss that’s caused by conditions like dandruff, says Mirmirani. Try Head & Shoulders Deep Moisture Shampoo ($6), and use a conditioner without silicones — they can make hair appear limper, especially if it's applied near the roots (we like Love Beauty and Planet Coconut Water & Mimosa Flower Conditioner, $9).
The trick about all of these hair-loss products and treatments is that they’ll stop working as soon as you stop using them. “They have to be ready for a lifetime commitment,” says Rieder. But, just like brushing your teeth, as long you keep on keeping on with the scientifically proven preventative treatments, those hairs on your head should be just fine.
BBC Newsbeat has released a documentary yesterday titled “Too Young To Go Bald.” The program gives a candid look into the lives of several young adults dealing with various forms of alopecia. Chidera Eggerue, a blogger dealing with traction alopecia, meets up with a female British rapper who previously underwent a hair transplant for her traction alopecia. Also in the documentary, vlogger Perry O’Bree who is dealing with androgenic alopecia shares about his own experiences.
In Vancouver, a Canadian company called RepliCel focusses on the hair follicle’s “dermal-sheath cup cells,” its C.E.O., Lee Buckler, explained. Buckler believes that DHT attacks these cup cells “like a parasite.” Like Histogen, RepliCel’s consumer product would be an injectable. The company would generate new versions of your cup cells, which would be implanted into your “affected area”—the places where your hair has fallen out. Boom: new hairs. (Theoretically.)
In just the past few years, we’ve made remarkable strides in understanding Trump’s head. In March, 2016, with Trump the presumptive G.O.P. nominee, Gawker’s Ashley Feinberg published a diligent and compelling investigation, “Is Donald Trump’s Hair a $60,000 Weave?” It pointed to a high-end clinic called Ivari International that, for a while, at least, had the kind of complicated ties to Trump and Trump Tower that we’d later see in the dignitaries of various hostile foreign governments.
However, each formula contains a different mix of ingredients and will act on preventing the hair loss process in a unique way. Perhaps one of the best things about these anti DHT shampoos is that they are mostly natural and organic compositions with little to no side effects. Probably your biggest risk in using one of these shampoos is a red or itchy scalp, which typically goes away after a couple hours following your shower.

You might think, "It's just hair", but think about this: What would you do if you wake up one day without a single strand of hair on your head? However, as we've mentioned, hair loss is a natural physiological process. In the hair growth cycle, old hair has to be shed in order for new hair to grow. As we age, our body's capacity to produce hair also slows down, similar to when our bones stop growing at a certain point in our lives.
The general medical consensus around laser treatments — caps and combs alike — is that low-level laser light therapy stimulates the cells within the hair follicle. These devices may also increase cell metabolism to promote thicker and more durable hair shafts, something that neither minoxidil or finasteride can do. To use the HairMax Ultima, all you have to do is glide the device over your scalp slowly. Treatments should take about eight minutes, and you should do it three days per week for the best results.

A diet that is poor or lacking in certain nutrients, particularly iron, protein, and vitamin B, which are essential in the production of keratin, can cause a long telogen phase and a very short anagen stage. On the other hand, excess supply of vitamin A in the body, especially those taken through supplements, can prove to be toxic and can cause a range of adverse body effects including loss of appetite, fatigue and consequently, hair loss.
David made this claim back in 2000. But fast-forward a few years and his enhanced compensation strategy begins to look a little quaint. Androgenetic alopecia, or male pattern baldness, afflicts about half of all men aged 50 and they can’t all reinvent the sitcom. And significant advances in the £3bn hair regrowth industry mean that they have other, seemingly easier, options. The man who is “ideally bald” (to use Vladimir Nabokov’s description of his comic hero, Pnin) may soon become a rare sight.
Where is the bald spot? What exactly are the dimensions of this bald spot? It’s all so stupid, so tiringly stupid. In May, Trump’s former personal physician, Harold Bornstein, revealed that Trump had sent people to seize all of his personal health records. Bornstein called it a “raid” that left him feeling “raped, frightened, and sad.” He also claimed that it was revenge for having revealed to the media that Trump was on Propecia.
The thing is that these big drug companies have shelled out millions and even billions of dollars to research, develop, market and then sell a drug-based product that consumers want. Therefore, they will do everything in their power to protect and guard their products against any drug-free alternatives. The kicker is even if said alternatives are cheaper and safer for consumers, while also achieving the same goals for them! This is the crux of claim enforcement, which is really about claim ownership and claim protection from the perspective of the big drug companies.
From the top of my head, I don’t remember if the Lipogaine’s Big 3 Shampoo contains ketoconazole but if it does, then that’s a definite plus. Another thing you can do is buy Nizoral and use it in conjunction with The Big 5 Shampoo. So for example, use Nizoral on Mondays and Thursdays and The Big 5 in all the days in between. That way you’d get all the benefits.
"Others are taking hair follicles out of human scalp and growing them with dermal papilla cells," Cotsarelis says. "If they grow in culture, you might be able to recombine them with skin cells and form new follicles. This would let you expand the number of follicles you get for a hair transplant. This may not be that far off -- five to 10 years, maybe. There's very good evidence you will be able to do that."
To us, that meant any product with zero proven ingredients, case studies, or FDA clearance — which shrunk our list by a whopping 180 contenders. That’s right, there are only three treatments that have actually been cleared by the FDA and supported with clinical studies: finasteride (commonly marketed as Propecia), minoxidil, and laser treatments. And, since finasteride is prescription-only, it left us with two.
But the male propensity to internalise their feelings often leaves them particularly vulnerable. “I know guys who have changed their career paths because of their hair loss,” says Kobren. “I know a lawyer who began delivering potato chips so he could wear a cap to work. I know an NYPD officer who was so devastated by a bad transplant, he had to retire and he ended up on disability benefit.”

Central centrifugal cicatricial (scarring) alopecia: This type of hair loss occurs most often in women of African descent. It begins in the center of the scalp. As it progresses, the hair loss radiates out from the center of the scalp. The affected scalp becomes smooth and shiny. The hair loss can be very slow or rapid. When hair loss occurs quickly, the person may have tingling, burning, pain, or itching on the scalp. Treatment may help the hair re-grow if scarring has not occurred.
Female pattern baldness: Treatment and genetics While most women lose between 50 and 100 strands of hair per day, this hair is usually quickly replaced by new growth. When bald patches or thinning occurs, however, it may be a sign of female pattern baldness. In this article, learn more about the common causes and treatment of hair loss in women. Read now
Approved by the FDA and available in over-the-counter form for both men and women, minoxidil has been found to work in two out of three men. However, and this is a huge problem, if you stop using it, then your hair will actually fall out again and potentially faster than before. Plus, you might not even notice any changes until you’ve been using this medication for at least four months!
A separate study, published in Skin Therapy Letter — a professional reference site for dermatologists — found that women also benefit from using the more potent 5 percent minoxidil treatment. “Patient-reported improvement in hair volume and coverage appears to be greater with 5 percent minoxidil foam,” reads the report. Plus, because the 5 percent treatment is stronger, women only have to apply it once a day to get the same results as they would with the 2 percent treatment applied twice daily.
However, this partnership ended in 2007 due to potential safety issues since SHH can potentially also cause basal cell carcinoma cancer. P&G was not willing to continue with the drug development work, since even a very minimal risk of developing cancer is not worth it for treating a cosmetic problem such as hair loss (at least in the eyes of government). Interesting comment from the at-the-time CEO of Curis:
Giovanni Mele, a stylist who owns Giovanni and Pileggi in Center City, said many women with thinning hair try to wear their hair long. He thinks they're much better off with short, pixie-like styles with light layering on top. He recommends that lighter-skinned women choose colors that are a little darker than blond or gray. He is a fan of a hair-thickening product made by Nioxin.
Minoxidil (Rogaine). Minoxidil is one of the most common and popular forms of medication for hair loss, particularly pattern baldness, but also generally used in cases of alopecia areata. It is an over-the-counter drug that comes in either liquid or foam form and is applied on the scalp, particularly on the bald patches, to promote hair growth and stop further hair loss. 

I’ve been looking forward to sharing this with you all. It makes me laugh everytime I watch it. But really, look at how happy he really is and how much joy he feels from restoring his hair. The man is an NFL Hall of Famer, also played MLB, and made millions of dollars throughout his career; and he looks like a kid getting free ice cream on a Friday afternoon because his hair grafts are beginning to sprout. I find it inspiring, to be honest. Keep dreaming, keep believing. We’re all looking forward to having our own “I got some hair!”  moment.
Anagen effluvium is usually reversible, with regrowth one to three months after cessation of the offending agent. Permanent alopecia is rare. A large meta-analysis of clinical trials concluded that scalp cooling was the only intervention that significantly reduced the risk of chemotherapy-induced anagen effluvium.27 However, scalp cooling should be discouraged because it may minimize delivery of chemotherapeutic drugs to the scalp, leading to cutaneous scalp metastases.27
Finasteride has limitations though, such as the requirement of daily treatment, a limit to how many damaged hair follicles it can revive, and that it may lose its effectiveness overtime for some people. This drug has shown to be better at preventing further hair loss than reversing it (regrowth). Just keep in mind that some side effects might make the hair loss seem more appealing.

Alopecia areata: Researchers believe that this is an autoimmune disease. Autoimmune means the body attacks itself. In this case, the body attacks its own hair. This causes smooth, round patches of hair loss on the scalp and other areas of the body. People with alopecia areata are often in excellent health. Most people see their hair re-grow. Dermatologists treat people with this disorder to help the hair re-grow more quickly.
During this procedure, surgeons remove a narrow strip of scalp and divide it into hundreds of tiny grafts, each containing just a few hairs. Each graft is planted in a slit in the scalp created by a blade or needle in the area of missing hair. Hair grows naturally this way, in small clusters of one to four follicles, called follicular units. As a result, the graft looks better than the larger "plugs" associated with hair transplants of yesteryear.
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