What's to know about alopecia areata? Alopecia areata is an autoimmune disorder that usually results in unpredictable, patchy hair loss. Approximately 7 million people in the U.S. have alopecia areata, and it can affect anyone of any age or gender. There is no cure for alopecia areata although some treatments are available to help hair regrow more quickly. Read now
Hair transplant/surgery. A hair transplant or surgery is the quickest treatment for permanent cases of hair loss, although the most expensive. In pattern baldness, for example, where the top of the head is the most affected area, a hair transplant allows the surgeon to use existing hair to implant it into the bald sections of the head. It works by removing a graft or follicular sample in parts of the head that still have hair (usually this is the back of the head as this area is most resistant to hormonal changes), and placing this graft in the areas that are bald.
The general medical consensus around laser treatments — caps and combs alike — is that low-level laser light therapy stimulates the cells within the hair follicle. These devices may also increase cell metabolism to promote thicker and more durable hair shafts, something that neither minoxidil or finasteride can do. To use the HairMax Ultima, all you have to do is glide the device over your scalp slowly. Treatments should take about eight minutes, and you should do it three days per week for the best results.
Hair grooming, but more importantly, having a head-full of hair is as important to men as it is to women. To women, it may be an important accessory of beauty, and for men, it adds to a sense of manliness, enhances their looks and makes them more appealing and attractive to women. Balding to men is associated with aging (only old men are expected to lose hair) and therefore, having hair on one's head is a sign of virility and masculinity.
The best fix by far for replacing lost hair is a transplant. Back in the day, docs used plugs that resembled cornrows (definitely not natural looking). Today, guys have more options. You can go for “the strip method” where a doctor surgically removes a strip of hair from the back of your head, dissects every hair graft under a microscope, and then plants the individual grafts onto hair-thin areas of your scalp with tiny incisions.
Late last week, HairClone officially unveiled its crowdfunding campaign with the Euro-based crowdfunding company Capital Cell. HairClone is offering equity based crowdfunding, which means anyone who makes an investment (£500 minimum) owns equity in the HairClone company. Full details on the campaign are listed in the latest HairClone article on the main page of Follicle Thought.
Generally, hair problems, especially hair thinning and hair loss, occur around the anagen phase or the resting phase. As we age, the length of the anagen phase also decreases as the hair follicles receive less and less nourishment from the body. The result is hair that is weaker and thinner after every cycle. In some cases, the hair enters the resting phase too early (or the catagen phase is too short) and this is when excessive shedding also happens.
In the nineteen-forties, a Brooklyn anatomist named James Hamilton studied prisoners in Oklahoma who, having been convicted of sexual assault, were castrated. Hamilton identified testosterone as the root of hair loss, and showed that men castrated before or during puberty did not go bald. He then injected groups of castrated adult men with testosterone and—duly, cruelly—watched their hair fall out.
I hope you’re all having a good Friday and feeling good out there. Two weeks ago I posted my first “Feel Good Friday” update which contained a hilarious video of Deion Sanders showing off his new hairline from a 5,000+ FUE procedure he had in 2017. That video is now unable to embed because its owner changed his account to private. Coincidentally, a week after I shared that video I noticed that Deion posted a new video to his own Instagram account of him going back to his clinic for another FUE hair transplant to “comeplete his comeback”, in his own words.
Farrell makes what he calls “hair systems.” They’re not quite wigs or toupees—you can keep them on for weeks at a time. They cost more than a thousand dollars. Farrell was in New York for a week, holding meetings with clients in his hotel room. Now his rolling suitcases were packed. Malaysia, Singapore, South Africa, Russia: he’s almost always on the road, satiating international demand for high-end hair pieces.
This video is equally hilarious. Once again, there is inspiration here. Deion had a 5,000+ FUE last year and received good results from it. But he’s not done yet, he has the resources to have another procedure and get as close as he can to the result that he really wants, so he did. Surely, he’s just about maxing-out his donor area now. Once again, congratulations to Deion for pursuing his hair growth goals. Enjoy the video and have a big laugh. OOOOeeee.
Minoxidil and oral finasteride are the only treatments currently approved by the U.S. Food and Drug Administration for the treatment of androgenetic alopecia. Both of these drugs stimulate hair regrowth in some men, but are more effective in preventing progression of hair loss. Although there are a number of other treatments listed in various texts, there is not good evidence to support their use.8
You might think, "It's just hair", but think about this: What would you do if you wake up one day without a single strand of hair on your head? However, as we've mentioned, hair loss is a natural physiological process. In the hair growth cycle, old hair has to be shed in order for new hair to grow. As we age, our body's capacity to produce hair also slows down, similar to when our bones stop growing at a certain point in our lives.
The law enhances the FDA’s ability to modernize clinical trial designs and clinical outcome assessments, which will perhaps speed the development and review of novel medical products, including medical countermeasures. The Cures Act also directs the FDA to create so-called “intercenter institutes” to help coordinate activities in major disease areas between the drug, biologics and device centers and improves the regulation of combination products. An example of one of these centers is the Oncology Center of Excellence.
A clinical researcher who has spent decades researching the fields of pattern hair loss, alopecia areata, endocrinology of the hair follicle and hair follicle morphogenesis, Hoffmann works in his private practice, as a teaching professor in the Department of Dermatology at the University of Marburg and as a researcher on histopathology on hair diseases. He has participated in dozens of clinical hair studies and is the inventor of TrichoScan®, a computerized technique to measure hair growth.
It’s also possible that some of Harklinikken’s users are women whose hair would have grown back even if they’d done nothing. Many women who arrive in a dermatologist’s office with prior diagnoses of female pattern hair loss actually have what’s called telogen effluvium. That’s a period of acute shedding of hair — meaning up to 60 percent of hair — three months after a triggering event like pregnancy, significant weight loss or starting or stopping hormone medications.
In most cases though, it's all a matter of attitude. Being bald should not be a cause of stigma. It does not make you less of a person or less masculine, less virile, and less attractive and appealing. In fact, a clean shaven head is becoming a popular trend among men these days, and there are certainly many bald men who have managed to make themselves look clean, elegant and suave despite their hair loss. Learn to come to terms with it. It's hair loss, yes, but not brain damage. It does not affect your core.
Certainly a company with a unique background and game plan, HairClone has received some recent media attention. The UK biotech startup was featured in this month’s publication of “Consulting Room” online magazine. In the article both Dr. Bessam Farjo and Paul Kemp of HairClone provided insight as to the company’s current progress and plans for the future. Things seem to be coming along well for HairClone and we should expect to hear from them again within the next several weeks. Full story is on Articles main page.
Pfizer Reports Positive AA Trial Results – A JAK3 inhibitor and a tyrosine kinase inhibitor (TYK2/JAK1) have shown statistically significant results in a phase 2a trial conducted by Pfizer. The company announced the results on September 15, 2018 at the European Academy of Dermatology and Venerology Congress. Subjects of the trial received oral doses of the drugs over a 6 month period. The TYK2/JAK1 inhibitor showed the greater efficacy, improving hair regrowth by 49.5 points on the Severity of Alopecia Tool scale, compared to an improvement of 33.6 points by the JAK3 inhibitor. However, Pfizer has apparently decided to move forward with its JAK3 inhibitor due to 2 adverse events in the TYK2/JAK1 inhibitor cohort during the trial. Pfizer’s JAK3 candidate, PF-06651600, was also recently granted Breakthrough Designation from the US FDA for treating alopecia areata.
I’ve been looking forward to sharing this with you all. It makes me laugh everytime I watch it. But really, look at how happy he really is and how much joy he feels from restoring his hair. The man is an NFL Hall of Famer, also played MLB, and made millions of dollars throughout his career; and he looks like a kid getting free ice cream on a Friday afternoon because his hair grafts are beginning to sprout. I find it inspiring, to be honest. Keep dreaming, keep believing. We’re all looking forward to having our own “I got some hair!” moment.
I noticed significant thinning, and hair all over the sink every morning, from breakage; I use a flat iron sometimes, and my hair is color-treated. I have since started using coconut oil to help manage my frizzy damaged naturally curly hair. It acts as a wonderful styling product, it lends shine and manageability, has also stopped the breakage, you just have to be very careful with the amount that you use. I also use castor oil and rosemary essential oil on my scalp at night and wash in the morning….egg is supposed to be useful for its proteins (must rinse after 20 min with cool water!!) And mayonnaise too, but I haven’t tried that. Best of luck, Friend….
These days, when forced into windy outdoor situations, Trump is nearly always seen wearing a Make America Great Again cap. But, one wintry, blustery day this February, Trump walked up the steps of Air Force One capless. In the engrossing video footage, you can see the hair on the back of Trump’s head part and rise, shooting up with power, almost in two separate flaps—one to the left, one to the right.
“Smelling” Receptor Keeps Hair Growing – Many of you may have noticed the headlines regarding sandalwood and hair growth over the past week. The research everyone is talking about comes from Ralf Paus and his team at the Monasterium Laboratory GmbH. For the record, Paus is also the main researcher behind the WAY-316606 hair growth discovery. This time Paus et al identified an olfactory receptor in hair follicles, OR2AT4, which plays a role in regulating hair growth or inhibition. Olfacory receptors are responsible for detecting odors in cell membranes and provide the basis for our sense of smell, they do carry out additional functions though, as demonstrated by Paus.
There seems to be some contention over whether hair products like hair sprays, hair gels and serums can lead to hair loss. What's true though is that frequent use of these products can damage your hair, either make it thinner or more prone to breakage. Limit the use of these products for those occasions when you absolutely need to. If you use hair products with harsh chemicals, especially hair sprays, wash your hair at night with a mild shampoo to get rid of the chemicals.
Yet another company has made news this week for phase 2 trial progress. Concert Pharmaceuticals announced today that they have completed enrollment for their phase 2a trial using CTP-543 in alopecia areata. CTP-543 is an oral JAK inhibitor which acts on JAK 1 and 2, it’s also known as ruxolitinib. Concert’s version of ruxolitinib has been modified by the company’s proprietary deuterium chemistry technology which the company hopes will improve its effects on AA.
Caffeine – Quickly finding its way in to many skincare products for both men and women, caffeine is a natural antioxidant that not only fights free radicals that accelerate the signs of aging, but also help to stimulate the growth of hair. In fact, in a recent study published on the National Institute of Health (NIH) website, it was discovered that there were ‘growth-promoting effects’ to the hair with regular application (source).
Deionized Water, Sodium Laureth Sulfate, Cocamidopropyl Betaine, Sodium Cocoyl Alaninate, Polyquaternium-7, Sodium PCA, Aloe Barbadensis Leaf Juice, Apigenin, Biotinoyl Tripeptide-1, Butylene Glycol, Camellia Sinensis (Green Tea) Leaf Extract, Fragrance (Parfum), Glycerin, Glycine (Amino Acid), Guar Hydroxypropyltrimonium Chloride, L-Arginine, Larix Europaea (Larch) Wood Extract, Niacinamide, Oleanolic Acid, PEG-150 Pentaerythrityl Tetrastearate, PEG-40 Hydrogenated Castor Oil, PEG-8 Caprylic/Capric Glycerides, PG-26-Buteth-26, Propolis, Sodium Metabisulfite (Antioxidant), Zinc Chloride, Methylchloroisothiazolinone, Methylisothiazolinone, Disodium EDTA, Citric Acid.
A popular skin care drug—which is intended to target eczema—was just found to have an unusual side effect: hair growth. According to an article on Newsweek, the FDA-approved drug dupilumab was given to a 13-year-old alopecia sufferer to treat her eczema. The patient, who hadn’t grown hair on her scalp since she was two, suddenly grew a significant amount of hair on her head after continual use of the drug, a study in the journal JAMA Dermatology reports.
In 2013, RepliCel began working with the Tokyo-based Shiseido Company, Limited—a Japanese multinational skin care, hair care, cosmetics and fragrance producer—on a collaboration giving Shiseido an exclusive geographic license to use RepliCel’s RCH-01 hair regeneration technology in Japan, China, South Korea, Taiwan and the ASEAN countries representing a population of approximately 2.1 billion people. “Shiseido and RepliCel will collaborate on the continued improvement of the technology and will conduct human clinical trials in each of their territories with the goal of commercializing a safe and effective hair regenerative treatment to help those suffering from pattern baldness and thinning hair,” Buckler said.