Follica is developing a wounding device that when coupled with a hair stimulant like minoxidil, is found to be more effective at triggering new growth. They like to call this wounding process ‘skin disruption’. The idea behind this treatment is that after the skin is wounded, cells migrate to that area to repair. They then must choose between two paths: healing the skin (making epidermis) or making hair. It is there where Follica sees the window of opportunity, where they can encourage the cells to do the latter and regenerate new and more hair.
I’ve been updating the Ultimate Guide to Hair Regeneration 2018 a bit over the last several weeks. There are two new companies who made the list, although you’ve most likely heard of them before, and some positions have changed. Position changes usually happen when pivotal news gets reported or progress is made by a particular company. I’ve been meaning to work on the Guide for a while now and only recently found time for it in between writing new articles and other activities. 
In Vancouver, a Canadian company called RepliCel focusses on the hair follicle’s “dermal-sheath cup cells,” its C.E.O., Lee Buckler, explained. Buckler believes that DHT attacks these cup cells “like a parasite.” Like Histogen, RepliCel’s consumer product would be an injectable. The company would generate new versions of your cup cells, which would be implanted into your “affected area”—the places where your hair has fallen out. Boom: new hairs. (Theoretically.)
In either sex, hair loss from androgenetic alopecia occurs because of a genetically determined shortening of anagen, a hair's growing phase, and a lengthening of the time between the shedding of a hair and the start of a new anagen phase. (See "Life cycle of a hair.") That means it takes longer for hair to start growing back after it is shed in the course of the normal growth cycle. The hair follicle itself also changes, shrinking and producing a shorter, thinner hair shaft — a process called "follicular miniaturization." As a result, thicker, pigmented, longer-lived "terminal" hairs are replaced by shorter, thinner, non-pigmented hairs called "vellus."
There seems to be some contention over whether hair products like hair sprays, hair gels and serums can lead to hair loss. What's true though is that frequent use of these products can damage your hair, either make it thinner or more prone to breakage. Limit the use of these products for those occasions when you absolutely need to. If you use hair products with harsh chemicals, especially hair sprays, wash your hair at night with a mild shampoo to get rid of the chemicals.

Originally spotted this on HairLossCure100’s twitter page. Concert Pharmaceutical’s therapy for alopecia areata, CTP-543, has been granted fast track designation from the FDA. CTP-543 is an oral JAK inhibitor (ruxolitinib). From what I’ve read, fast track designation encourages early and frequent communications between the FDA and the company during the development process to ensure issues and questions are resolved quickly.


Joseph and his readership, he said, are convinced that we are at a “peak moment” for the industry. He ticked off “platelet-rich plasma” and “injectable cell therapies” and other high-level technologies that are being developed by companies from New York to San Diego, Tokyo, and Stockholm. He won’t make bets on who’s going to win the arms race. But, he says, “if you were the first, that’d be fun for the trillion dollars that you’d make. Over the next few years? It’s prime time.”

The truth is, the amount of propylene glycol in hair loss treatments is not likely to cause any real harm and the FDA has given the chemical approval for many uses. But even though it is safe, we wanted to ensure that our top picks would be as comfortable to use as possible. So when Dr. Khadavi told us that “a third of my patients get irritated from minoxidil products because of propylene glycol,” we decided to cut any treatments with it. In any case, it’s the minoxidil that helps curb hair loss and not the propylene glycol.
It is no surprise that Donald Trump is obsessed with hair loss. “Never let yourself go bald,” he once told a Trump Organization executive. “The worst thing a man can do is go bald.” During their brief dalliance, Stormy Daniels confronted him about his hair. “I was like, ‘Dude, what’s up with that?’ ” she said, to In Touch, in 2011. Trump laughed. Then he told her that he worried that “if he cut his hair or changed it, that he would lose his power and his wealth.” Recently, Trump’s physician admitted that the President takes the anti-baldness medicine Propecia.
Buckler said it started in 2003 with the academic research of Hoffmann and McElwee at the University of Marburg in Marburg, Germany. At the time they were trying to understand what was happening in the hair follicles of people suffering from androgenetic alopecia—a common form of hair loss in both men and women—or the underlying cause of hair loss.
There seems to be some contention over whether hair products like hair sprays, hair gels and serums can lead to hair loss. What's true though is that frequent use of these products can damage your hair, either make it thinner or more prone to breakage. Limit the use of these products for those occasions when you absolutely need to. If you use hair products with harsh chemicals, especially hair sprays, wash your hair at night with a mild shampoo to get rid of the chemicals.
McElwee is an associate professor in the Department of Dermatology and Skin Health at the University of British Columbia (UBC) in British Columbia, Canada and director of the Hair Research Laboratory in the Vancouver Coastal Health Research Institute (VCHI) at Vancouver General Hospital (VGH). A hair research scientist, McElwee is one of only a small group of research scientists worldwide who studies hair biology and associated diseases.

Over the past year, the Hair Restoration Laboratories’ Professional Strength DHT Blocking Hair Loss Shampoo (and accompanying DHT Blocking Hair Loss Conditioner) has been a top seller on Amazon and many other sites. Combined, the daily use Shampoo and Conditioner has more DHT blockers than any shampoo/conditioner set presently available. Among the key DHT Blockers in this set are: Caffeine, Saw Palmetto, Black Cumin Seed Oil, Cayenne Fruit Extract, Rosemary Leaf Oil, Pumpkin Seed Oil, Green Tea Leaf Extract, Pea Extract and many more. By helping to block DHT, they should be a great asset in helping to halt the miniaturization of the hair follicles and regrow healthier and thicker hair.
Finally, if these tests come back normal, your dermatologist may suggest a scalp biopsy of a couple of two-millimeter sections taken from your scalp under local anesthesia ($400 and up). It can determine whether genetic hair loss, telogen effluvium (a condition in which hair falls out from stress or rapid weight gain), or a disease (such as lupus) is the cause of your shedding, and your dermatologist can treat you accordingly.
“We don’t know why, but we have universally established that the cells back there are immune to the attack,” Buckler said. That’s why doctors have worked at relocating follicles from the back of the head to the front to attempt to cure baldness. “That’s proven. If you relocate those cells, they’ll remain immune. “But that is a messy, bloody surgical procedure.”
Laser treatments are the latest frontier in staving off hair loss, and they’ll be the first choice for fans of sci-fi. As silly as they may sound, these treatments do work — the American Journal of Clinical Dermatology in 2014 reported a “statistically significant difference” in hair density with no “serious adverse events” or side effects.The bad news: Laser treatments tend to be expensive, progress is slow, and they don’t always produce stellar results.

I represent a hair company that helps with keeping your hair healthy and detoxifying the scalp of any toxins. I have a bunch of testimonials from women with hair loss from stress, pregnancy, aging, and other cases. I’d be willing to introduce you to these products. I use these products and my hair has transformed as wel.. Let me know if you’re interested. I’m sorry to be a bother!
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I’ve been looking forward to sharing this with you all. It makes me laugh everytime I watch it. But really, look at how happy he really is and how much joy he feels from restoring his hair. The man is an NFL Hall of Famer, also played MLB, and made millions of dollars throughout his career; and he looks like a kid getting free ice cream on a Friday afternoon because his hair grafts are beginning to sprout. I find it inspiring, to be honest. Keep dreaming, keep believing. We’re all looking forward to having our own “I got some hair!”  moment.
Men’s Rogaine Extra Strength Solution is the liquid version of our top pick. It didn’t make our final cut because it includes propylene glycol, which causes irritation in roughly one-third of its users. With that said, Dr. Wolfeld finds that it can be even more effective in practical daily use. In his experience, “the solution can penetrate and get into your scalp a little bit better” than the foam — especially if you’re not taking the time and effort to apply the foam correctly. This seems crazy to us since the foam so quickly dissolved into a liquid in our tests, but if you’re worried, try a one-month supply of the liquid and make the switch to foam if you notice any irritation.
Would there be any harm/benefit in combining the use of two hair-loss prevention shampoos, to take advantage of different ingredients and functions? Mainly Nizoral, at the twice a week recommendation, plus the Argan Oil Shampoo twice a week? I have somewhat oily hair and do get dandruff from time to time, but I do feel after washing my hair, it can feel dry and stiff. Just wondering if a combination of the two (one for dandruff, and one for healthy, thicker hair) might prove effective. Also, would you have any recommendations on a combo? Thanks!
Consider other factors besides color. Color is important - your wig or hair piece should match your natural hair to look natural. However, consider also texture. You wig should feel like real hair; it should have a smooth and silky feel. For those that need full coverage, choose a wig that bounces to give the illusion of volume. A wig that has a lacing that fits your natural hair also helps in making sure that you have a more natural looking hairline.
Besides cost considerations, a hair transplant is generally prescribed as a last resort for permanent hair loss problems. It is also not allowed for people under the age of 25, those with a continuing problem of hair loss, as well as those with other health conditions like uncontrolled diabetes, serious heart problems and hypertension. Patients whose hair loss is caused by other factors, such as a skin or scalp disorder or who suffer from a psychological condition that causes them to pull at their hair are not recommended for this procedure. Since the procedure requires taking a sample from the back of the head, those who do not have enough follicles from this section that can be used for transplant are not also eligible.

Alopecia areata. This condition, called patchy hair loss, is the opposite of pattern baldness. Whereas in the former, thinning hair follows a pattern, alopecia areata is marked by smooth and bald patches anywhere on the scalp. The bald patches are circular, and can be as small as a pencil eraser or as big as a quarter. It begins with one or two spots that multiply on other parts of the head. The condition is caused by an autoimmune disease where the antibodies mistake the hair as the "enemy" and start attacking it, resulting into hair loss.
Coconut milk / coconut oil. Coconut milk/oil, like aloe vera, is one of the oldest and most common natural ingredients for promoting hair growth and growing healthy, shiny hair. Coconut is rich in protein, iron and other minerals that promote healthy hair and prevent breakage. Apply the coconut milk/oil on your bald spots or all over the scalp, and leave it on overnight. Rinse the next day with cool water. You can do this every time you wash your hair.
I am so happy with this product. I have thinning hair and have used many products in the past trying to at least stop it. I don't expect a miracle for it to grow back but I would love to just stop the hair falling out. Immediately after using this just one day I already noticed improvements. I was told my hair shined more, it was softer and also fuller. The hair falling out has improved a lot. I have not personally noticed hair growth yet but its only been 2 weeks now and I can say without a doubt it has made my hair healthier. I will be getting more for sure
The key ingredient in Nizoral is ketoconazole, which reduces hair follicle inflammation that contributes to hair loss. Ketoconazole also kills fungi that cause dandruff, but there’s not so much of it as to be toxic (which large amounts of ketoconazole can be). It has been argued that dandruff may contribute to hair loss; while there’s no direct link, it’s certainly worth noting here.
In our research and our conversations with experts, one name kept popping up repeatedly: Rogaine. As the first topical brand FDA-approved to help regrow hair (all the way back in 1988), Rogaine benefits from more than 20 years of clinical trials and consumer feedback. Rogaine was the first brand to offer a 5 percent minoxidil foam solution when it debuted Men’s Rogaine Unscented Foam in 2006, and virtually every treatment developed since (for both men and women) has been an imitation or derivation of that formula.
For the first twenty years of my life, I took having hair for granted. One day, in college, I woke up and looked in the mirror, and was convinced that my hair was falling out. Not receding—dropping, that minute. Later that day, I told a roommate. He took a beat, and then asked, not without kindness, “Were you on PCP?” That semester, in a creative-writing workshop, I was moved enough to write a long, confused story about a teen-ager with male-pattern baldness who suffers a meltdown and robs the hot-dog counter where he works. By my late twenties, hair loss was something that I thought about all the time. I understood, largely, that my obsession was a specific expression of a more general anxiety. I’ve never been to therapy. There are many things that have led me to consider it. But one of the most distinct, definable, and pressing has been my obsession with hair loss.
I am a 45 yr female that has experienced hair loss to the point of having to hire a plumber twice (over 3 years) to unclog our drain in our main bathroom although I am pretty cautious about picking up my hair. My ponytail is about 1/2 the size that it was 5 years ago. i had excessive hair loss after the birth of my last 2 of 3 children. It is noticeably thinner although my employees, friends and husband seem to think my hair is thick. I can see my scalp very easily. (No patchy alopecia though) I started using viviascal professional strength about 2 months ago and hair surge shampoo only about 2 weeks ago. The bottle has about 1/3 left and i am wondering what is to be expected from this product. I have to use at least 8 pumps ( it seems to be double the volume of normal shampoo that i use) and it does not seem to later that well until after a min or so. Additonally i am using the hair surge supplement. When should i see less hair falling out? When should i expect visible results. Any other suggestions? I know it says to use 5 of 7 days, but i use it daily to make sure i am getting the full benefit ( if any) from this product. Currently i am looking at 100 buck a month for the shampoo alone if i keep this up. Any advice is welcome. Thanks

And just like that, more fascinating hair-related research was published in PLOS Biology. A team of researchers lead by Dr. Nathan Hawkshaw of the University of Manchester have identified the drug ‘WAY-316606’ as a potential candidate for hair regrowth. WAY-316606 is an existing drug used to treat osteoporosis. It’s not clear at this time whether WAY-316606 is approved and on the market, or if it was partially developed to treat the bone disease.


As I entered a small operating room at Bernstein’s Midtown East medical practice, a front-desk secretary shouted out, “Hope you got a strong stomach!” Inside, a patient dozed in an operating chair, while nurses held a strip of back-of-the-head skin—something like a fat hairy caterpillar—with tweezers. They began dissecting the follicular units under a microscope. 

Follicle Thought is interested in connecting with scientists and startups who are working on hair growth or hair loss prevention research. If you or a colleague is working on hair growth please get in touch on the Contact page, even if you are not ready to share news on the site yet. Follicle Thought can offer networking and other resources to benefit your development. Thanks
A DHT Blocker Shampoo is any shampoo formula that contains known DHT inhibiting agents. DHT inhibiting agents usually act by preventing 5 alpha reductase from converting testosterone to dihydrotestosterone (DHT). Leading research agrees that DHT is the foremost cause of hair loss. DHT binds to sensitive hair follicles causing them to shrink and eventually to stop producing hair altogether.
Regarding the RCH news, is your source more reliable than Lee Buckler since he seems to know more about RCH than Lee buckler himself. Recently, Lee Buckler tweeted “We anticipate seeing data from the RCH-01 study in Japan sometime before year-end but the real answer is whenever the investigators/hospitals in charge of the trial (not us) decide to release the data once it ready”
David made this claim back in 2000. But fast-forward a few years and his enhanced compensation strategy begins to look a little quaint. Androgenetic alopecia, or male pattern baldness, afflicts about half of all men aged 50 and they can’t all reinvent the sitcom. And significant advances in the £3bn hair regrowth industry mean that they have other, seemingly easier, options. The man who is “ideally bald” (to use Vladimir Nabokov’s description of his comic hero, Pnin) may soon become a rare sight.

Niacin, also known as vitamin B3, is another vitamin that you can find in a lot of men’s hair loss shampoos. Like biotin, niacin and its derivatives are scientifically proven to increase hair growth when topically applied to hair growth areas over the course of several months. However, it's important to call out that this pilot study used female participants.
During a hair transplant procedure, a dermatologist or cosmetic surgeon removes tiny patches of skin, each containing one to several hairs, from the back or side of your scalp. Sometimes a larger strip of skin containing multiple hair groupings is taken. He or she then implants the hair follicle by follicle into the bald sections. Some doctors recommend using minoxidil after the transplant, to help minimize hair loss. And you may need more than one surgery to get the effect you want. Hereditary hair loss will eventually progress despite surgery.
HCell Inc. announced this week in a press release the addition of two new members to its Board of Directors. Robert P. Ryan PhD and Marlene Haffner MD PhD comprise the additions to the Board. HCell mentions in the release that the respective additions will be supportive to HCell through their combined experience in orphan drug development and FDA regulatory processes.
Rogaine’s foam squirts out just like hair mousse and is applied with “cool, dry hands.” Applying means working the foam down to the scalp where you want to see thicker growth — for it to work, “it has to get into your scalp,” Dr. Wolfeld explains. “If it sits on your hair, it’s not really as effective.” Once massaged, it dissolves into a watery liquid that leaves a tingly sensation, “but no burning!” one of our balding testers was happy to discover.
That said, hair loss isn't as bad or as hopeless as it sounds. It shouldn't be cause for added personal stress or social stigma, nor should it be something that should make us feel more self-conscious and less confident as individuals. With the advances in technology, you don't have to be saddled anymore with the uncomfortable choice of wearing an ill-fitting, unnatural-looking hairpiece. There is now a wide array of options available to treat and cure hair loss, whether temporary or permanent.
Telogen effluvium is a nonscarring, noninflammatory alopecia of relatively sudden onset, with similar incidences between sexes and age groups. It occurs when large numbers of hairs enter the telogen phase and fall out three to five months after a physiologic or emotional stressor. The list of inciting factors is extensive and includes severe chronic illnesses, pregnancy, surgery, high fever, malnutrition, severe infections, and endocrine disorders. Causative medications include retinoids, anticoagulants, anticonvulsants, beta blockers, and antithyroid medications; discontinuation of oral contraceptive agents is another possible cause.17

The Holy Grail remains a drug that will promote regrowth, but this might not be so far away. Earlier this year, Manchester University announced that an osteoporosis drug had been found to have “dramatic results” promoting hair growth when applied to tissue samples in pre-clinical trials. The resultant frenzy left the PhD student responsible, Dr Nathan Hawkshaw, a little dazed. “Every other week, something comes out about hair loss and it doesn’t generate as much media coverage as what I experienced,” he grumbles. He’s in this for the science – there aren’t many fields where you get to mess around with real human tissue – but such is the distress caused by hair loss and such is the potential customer base that interest is always high.


After the groundbreaking 1999 study on mice, some researchers were mildly optimistic that SHH activation could also have positive implications on human hair growth in balding men and women. A new company that was formed in 2000 called Curis partnered with Procter & Gamble in 2005 to try and develop a topical Hedgehog agonist product for scalp hair growth.
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