I must have had about 5 readers email me today about the fascinating research coming out of Yokohama National University in Japan. Professor Junji Fukuda lead the efforts to successfully prepare “hair follicle germs” at large scale simultaneously. Essentially, the researchers prepared a cellular formulation with the right culturing materials to promote successful growth and development of tiny “hair follicle starter kits.” Source article here. 
In the operating room, Bernstein prepped the robot patient for implantation, puncturing the man’s scalp with a long needle. These are the “sites” where the hairs will go. Blood bubbled over his scalp, but the patient didn’t seem to notice. The patient and doctor chatted loosely about summer houses and beers and boats. “Would I be a candidate for a surgery after this surgery?” he asked.

Late last week, HairClone officially unveiled its crowdfunding campaign with the Euro-based crowdfunding company Capital Cell. HairClone is offering equity based crowdfunding, which means anyone who makes an investment (£500 minimum) owns equity in the HairClone company. Full details on the campaign are listed in the latest HairClone article on the main page of Follicle Thought.
Again, you’ll want to visit your doctor to get a blood test to check your levels in these vitamins. For example, women who have iron levels lower than 70 nanograms per milliliter are considered deficient. From there, work with your doctor to find an appropriate dose according to your deficiency level. Excessive or unnecessary supplementation can be dangerous.
A clinical researcher who has spent decades researching the fields of pattern hair loss, alopecia areata, endocrinology of the hair follicle and hair follicle morphogenesis, Hoffmann works in his private practice, as a teaching professor in the Department of Dermatology at the University of Marburg and as a researcher on histopathology on hair diseases. He has participated in dozens of clinical hair studies and is the inventor of TrichoScan®, a computerized technique to measure hair growth.
Trichotillomania may be difficult to diagnose if the patient is not forthcoming about pulling at his or her hair. Patients typically present with frontoparietal patches of alopecia that progress posteriorly and may include the eyelashes and eyebrows. Bare patches are typical, and the hair may appear uneven, with twisted or broken off hairs. Trichotillomania may lead to problems with self-esteem and social avoidance. Complications include infection, skin damage, and permanent scarring.18
I have only used this twice, but in that short time of use, I believe my hair shedding has increased. In fact, immediately following the last use my hair seemed to be coming out more than I had seen prior to ordering the shampoo at all. Experiencing hair loss, thinning, or excessive shedding (especially for a woman) can be very distressing, and to purchase a product in hopes that it will help to curb or even reverse the issue only to find it exacerbates the problem is INCREDIBLY stressful. I was hopeful about this product, given the overall reviews, but I'm afraid to use this product even one more time, for fear of making my hair loss worse.

All that said, our primary consideration for choosing hair loss shampoos for our list was whether it produced actual results. We also acknowledge that what might work for someone may not work for another, but we’re interested in the overall picture. Perhaps not surprisingly, the “big names” in the hair loss game – Lipogaine, Nizoral, etc. – made the grade, in part, because they’ve accumulated years of successful results.


Alopecia areata: Researchers believe that this is an autoimmune disease. Autoimmune means the body attacks itself. In this case, the body attacks its own hair. This causes smooth, round patches of hair loss on the scalp and other areas of the body. People with alopecia areata are often in excellent health. Most people see their hair re-grow. Dermatologists treat people with this disorder to help the hair re-grow more quickly.
In this simple, step-by-step book, I will reveal how to use a dermaroller to get new hair growth, a natural hair loss cure that helped me re-gain my old hair line, that doesn't involve any fancy drugs like minoxidil. In fact, all you really need in order to achieve the same results like me is a few basic ingredients that you can easily find online.

However, ketoconazole is still not FDA approved for hair loss treatment, which means it cannot be endorsed or marketed as such. Put simply, ketoconazole likely curbs hair loss, but additional research is needed for the FDA to give it approval. While it is safe to use as a supplement to our top picks, we wanted to recommend products with as much scientific backing as possible. So, we stuck with FDA approved minoxidil or FDA cleared laser treatments. But we’ll keep a close eye on products like ketoconazole shampoos and update as new research appears.
Hair transplant/surgery. A hair transplant or surgery is the quickest treatment for permanent cases of hair loss, although the most expensive. In pattern baldness, for example, where the top of the head is the most affected area, a hair transplant allows the surgeon to use existing hair to implant it into the bald sections of the head. It works by removing a graft or follicular sample in parts of the head that still have hair (usually this is the back of the head as this area is most resistant to hormonal changes), and placing this graft in the areas that are bald.
What's to know about alopecia areata? Alopecia areata is an autoimmune disorder that usually results in unpredictable, patchy hair loss. Approximately 7 million people in the U.S. have alopecia areata, and it can affect anyone of any age or gender. There is no cure for alopecia areata although some treatments are available to help hair regrow more quickly. Read now

A company not previously discussed in online news, SWITCH BIOTECH, has sights on developing a drug for androgenic alopecia. As you will see, the company is still in the very early stages of developing a therapy for AGA, however they are a knowledgeable dermatology-focused company and have a unique method of drug development. Here’s a quote from their website about working on AGA:


I am so happy with this product. I have thinning hair and have used many products in the past trying to at least stop it. I don't expect a miracle for it to grow back but I would love to just stop the hair falling out. Immediately after using this just one day I already noticed improvements. I was told my hair shined more, it was softer and also fuller. The hair falling out has improved a lot. I have not personally noticed hair growth yet but its only been 2 weeks now and I can say without a doubt it has made my hair healthier. I will be getting more for sure
If you have something that works for you, don’t change. Search for products that have plenty of positive feedback and don’t just trust Amazon reviews, but dig deeper. Again, most shampoos that claim to halt hair loss and grow new hair are nothing more than snake oil. Stick with ingredients that are clinically proven to work and backed by scientific study.
I feel inspired to share on the Updates thread a few uplifting comments I received from readers in the past week. Following my admonition to a previous commenter that sending out short, supportive emails to hair growth companies (without asking for extra information that you know they are not ready to share) would be a worthwhile endeavor and boost morale, I received some encouraging responses from two frequent visitors of this site who followed through on the idea. Their comments are shared below. 🙂
As I entered a small operating room at Bernstein’s Midtown East medical practice, a front-desk secretary shouted out, “Hope you got a strong stomach!” Inside, a patient dozed in an operating chair, while nurses held a strip of back-of-the-head skin—something like a fat hairy caterpillar—with tweezers. They began dissecting the follicular units under a microscope.

These days, when forced into windy outdoor situations, Trump is nearly always seen wearing a Make America Great Again cap. But, one wintry, blustery day this February, Trump walked up the steps of Air Force One capless. In the engrossing video footage, you can see the hair on the back of Trump’s head part and rise, shooting up with power, almost in two separate flaps—one to the left, one to the right.
McElwee is an associate professor in the Department of Dermatology and Skin Health at the University of British Columbia (UBC) in British Columbia, Canada and director of the Hair Research Laboratory in the Vancouver Coastal Health Research Institute (VCHI) at Vancouver General Hospital (VGH). A hair research scientist, McElwee is one of only a small group of research scientists worldwide who studies hair biology and associated diseases.
Kuntzman described the “snake oil” era of hair restoration, in the early twentieth century, when salesmen offered nonsense treatments, often with horrific results. One involved “cylinders of skin taken from the abdomen and sewn into your scalp to function as a sort of belt loop” for new hairs, Kuntzman said; another used paraffin injections that left some customers with lifelong horn-like head bumps. Most of the really ugly stuff ended in 1938, when the Food and Drug Administration began regulating the industry.
During a hair transplant procedure, a dermatologist or cosmetic surgeon removes tiny patches of skin, each containing one to several hairs, from the back or side of your scalp. Sometimes a larger strip of skin containing multiple hair groupings is taken. He or she then implants the hair follicle by follicle into the bald sections. Some doctors recommend using minoxidil after the transplant, to help minimize hair loss. And you may need more than one surgery to get the effect you want. Hereditary hair loss will eventually progress despite surgery.

“It all comes from the tissue taken from the back of the head. The hair follicle has a lot of Type 1 collagen in it,” he said. “We can isolate the hair-growing or collagen-producing cells and use them to start hair growth or regenerate degenerative tendons or tissues of skin. And it is a more natural way of doing it. There is nothing more natural than using your own cells to make your skin look healthy, to heal damaged tendons or to have a thicker head of hair.”

Chemotherapy is also one of the primary causes of balding among cancer patients, men and women alike. While not all chemotherapy treatments result in hair loss, some that involves the use of drugs like Altretamine, Carboplatin, Docetaxel, and Idarubicin can cause hair thinning and hair fall. In such cases, the hair loss varies from person to person and the dosage of drugs administered. Hair fall doesn't occur at once, but rather after several weeks of treatment until hair fall rate increases after one or two months of exposure to chemotherapy. Radiation therapy as part of cancer treatment can also result into hair loss but typically only in areas where the radiation is targeted.

The machine hummed, and the robotic arm extended out a thin steel needle, which it repeatedly and automatically punched into the marked-off area on the man’s head. It’s yanking out hair follicles, Bernstein explained: he had programmed the machine pre-procedure; now the robot knew exactly how deep to penetrate the skin and how far apart to make each incision. The patient rustled a bit and a nurse stopped him: “You can’t move your head.” Then, hoping to help him stabilize himself, she added, “You can hold on to the robot.”

Hair transplantation involves harvesting follicles from the back of the head that are DHT resistant and transplanting them to bald areas. A surgeon will remove minuscule plugs of skin that contain a few hairs and implant the plugs where the follicles are inactive. Around 15 percent of hairs emerge from the follicle as a single hair, and 15 percent grow in groups of four or five hairs.
As I entered a small operating room at Bernstein’s Midtown East medical practice, a front-desk secretary shouted out, “Hope you got a strong stomach!” Inside, a patient dozed in an operating chair, while nurses held a strip of back-of-the-head skin—something like a fat hairy caterpillar—with tweezers. They began dissecting the follicular units under a microscope.
Products like these come from huge pharma companies and are the direct beneficiaries of tens and even hundreds of millions of dollars worth of research and development, compliance, production and advertising. Since drugs have the capacity to significantly change your bodily functions and can cause threatening and undesirable side effects, there’s a need for the government to protect consumers via tough regulations.
Minoxidil (Rogaine). Minoxidil is one of the most common and popular forms of medication for hair loss, particularly pattern baldness, but also generally used in cases of alopecia areata. It is an over-the-counter drug that comes in either liquid or foam form and is applied on the scalp, particularly on the bald patches, to promote hair growth and stop further hair loss.
I hope you’re all having a good Friday and feeling good out there. Two weeks ago I posted my first “Feel Good Friday” update which contained a hilarious video of Deion Sanders showing off his new hairline from a 5,000+ FUE procedure he had in 2017. That video is now unable to embed because its owner changed his account to private. Coincidentally, a week after I shared that video I noticed that Deion posted a new video to his own Instagram account of him going back to his clinic for another FUE hair transplant to “comeplete his comeback”, in his own words.
Generally, hair problems, especially hair thinning and hair loss, occur around the anagen phase or the resting phase. As we age, the length of the anagen phase also decreases as the hair follicles receive less and less nourishment from the body. The result is hair that is weaker and thinner after every cycle. In some cases, the hair enters the resting phase too early (or the catagen phase is too short) and this is when excessive shedding also happens.
Due to the concern of several readers, I’ve removed the link to the new Trinov website that has popped up on the net. For now, the website only contains an email address subscription box which really poses no issue to anyone who subscribed. At this time, it’s not confirmed who the actual owner of the new Trinov site is, so use your discretion until we find out more regarding this matter. Until more information is known the website will not be shared on Follicle Thought.
“Smelling” Receptor Keeps Hair Growing – Many of you may have noticed the headlines regarding sandalwood and hair growth over the past week. The research everyone is talking about comes from Ralf Paus and his team at the Monasterium Laboratory GmbH. For the record, Paus is also the main researcher behind the WAY-316606 hair growth discovery. This time Paus et al identified an olfactory receptor in hair follicles, OR2AT4,  which plays a role in regulating hair growth or inhibition. Olfacory receptors are responsible for detecting odors in cell membranes and provide the basis for our sense of smell, they do carry out additional functions though, as demonstrated by Paus. 
Minoxidil: This medicine is applied to the scalp. It can stop hairs from getting thinner and stimulate hair growth on the top of the scalp. The U.S. Food and Drug Administration (FDA) has approved minoxidil to treat hair loss. It is the only hair re-growth product approved for men and women. A dermatologist may combine minoxidil with another treatment. 

When men have hereditary hair loss, they often get a receding hairline. Many men see bald patches, especially on the top of the head. Women, on the other hand, tend to keep their hairline. They see noticeably thinning hair. The first sign of hair loss for many women is a widening part. In rare cases, men see noticeably thinning hair. And in rare cases, women can see a receding hairline or bald patches. The reasons for this are unknown.
A separate study, published in Skin Therapy Letter — a professional reference site for dermatologists — found that women also benefit from using the more potent 5 percent minoxidil treatment. “Patient-reported improvement in hair volume and coverage appears to be greater with 5 percent minoxidil foam,” reads the report. Plus, because the 5 percent treatment is stronger, women only have to apply it once a day to get the same results as they would with the 2 percent treatment applied twice daily.
“I think their effectiveness is not as significant as finasteride or minoxidil,” says Dr. Wolfeld, “however, it’s something that can be used quite easily by patients at home. If they use it two or three times a week, I tell them it can help to thicken their hair.” Results can take up to 18 months to show up, so Dr. Wolfeld stresses that patience is a virtue.
Yet another company has made news this week for phase 2 trial progress. Concert Pharmaceuticals announced today that they have completed enrollment for their phase 2a trial using CTP-543 in alopecia areata. CTP-543 is an oral JAK inhibitor which acts on JAK 1 and 2, it’s also known as ruxolitinib. Concert’s version of ruxolitinib has been modified by the company’s proprietary deuterium chemistry technology which the company hopes will improve its effects on AA.
Tissue expansion. In this procedure, a material called a tissue expander is inserted under portions of the scalp with hair. Saline water is injected for six to eight weeks in order to expand or stretch this portion of hair-bearing skin. The bags are eventually removed and the expanded hair-bearing skin is cut away and moved to the adjacent bald area. This is typically used to address hair loss as a result of burns or injuries on the scalp.
Key features: Dr. Zeichner recommends the Keratin Oil Shampoo and Conditioner by OGX for thinning or fine hair that needs the extra strength. This budget-friendly option uses keratin proteins mixed with argan oil to nourish, condition, and strengthen strands, and it's only $16 for the set. The smoothing formula can also increase elasticity for less breakage and split ends.
JW Pharma, a Korean biotech company that specializes in the Wnt pathway, has entered a cooperative agreement with the University of Pennsylvania to development a compound called CWL08006 for hair regeneration purposes. JW Pharma has a pool of Wnt targeting therapies, and apparently CWL08006 makes a great candidate for hair growth. Of course, Dr. George Cotsarelis of UPenn is involved, and the two teams plan to begin preclinical testing by 2019 (I’m a little surprised at that timeline for preclinical). One of the more interesting facets of the report, JW intends “to accelerate its commercialization by launching tests on the human body for cosmetics that utilizes the drug’s mechanism, next year.” If the candidate works well in the cosmetic tests, a version of it could be made available much sooner than the clinical drug pathway, but for now it’s not possible to speculate a time frame for that yet. Good news all in all. 
This is a bestselling shampoo on Amazon. The list of ingredients is extremely lengthy. The product contain a number of natural organic DHT blockers (including saw palmetto) and various nourishing hair vitamins. Additional beneficial ingredients include amla oil, argan oil, pumpkin seed oil, rosemary oil, tea tree oil, green tea extract, niacin and biotin.
Unfortunately, as of now the video is only available on BCC Newsbeat for people living in the UK. I haven’t been able to watch it yet but am searching for a solution for those of us abroad to view the episode. One of the personalities featured in the film, Perry O’Bree, has created an interesting Youtube Video promoting the message that #HairLossHappens and that those who experience it are not alone. I find it to be a courageous and uplifting message. The topic often is often overlooked and understated, and the truth is that hair loss is much more of an important issue than how it is portrayed in society. Kudos to Perry.

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It's for this reason that grocery stores have shelves stocked full with hair care and hair grooming products of all forms and kinds, for different purposes, and even specialized and customized for use of men and women. In one study, it was found that more than half of the men in the UK use about six to ten hair grooming products alone, from the staple shampoos and conditioners to hair gels and other styling products.
This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. Contact afpserv@aafp.org for copyright questions and/or permission requests.
Unfortunately, as of now the video is only available on BCC Newsbeat for people living in the UK. I haven’t been able to watch it yet but am searching for a solution for those of us abroad to view the episode. One of the personalities featured in the film, Perry O’Bree, has created an interesting Youtube Video promoting the message that #HairLossHappens and that those who experience it are not alone. I find it to be a courageous and uplifting message. The topic often is often overlooked and understated, and the truth is that hair loss is much more of an important issue than how it is portrayed in society. Kudos to Perry.
The law enhances the FDA’s ability to modernize clinical trial designs and clinical outcome assessments, which will perhaps speed the development and review of novel medical products, including medical countermeasures. The Cures Act also directs the FDA to create so-called “intercenter institutes” to help coordinate  activities in major disease areas between the drug, biologics and device centers and improves the regulation of combination products. An example of one of these centers is the Oncology Center of Excellence.
Also known as Rogaine, this over-the-counter (OTC) medication can be used for men or women with alopecia areata or androgenic alopecia. This drug comes in foam or liquid form and is spread on the scalp each day. It may cause more hair loss at first, and new growth may be shorter and thinner than before. You may also need to use it six months or more to prevent further loss and promote regrowth.
Drugs normally used for rheumatoid arthritis and bone marrow cancer, they are now being studied for their uses as a hair growth medicine. These are a new class of medicines labeled as JAK inhibitors. In one study, 6 out of 9 patients dramatically went from bald to a full head of hair after taking Ruxolitinib for 5 months. In another study several subjects were able to regrow full heads of hair. Unfortunately, sustained use of such drugs will have severe side effects. Many of these concerns would be side stepped if a topical formula could be developed. Researchers at the Department of Dermatology and Genetics and Development at Columbia University Medical center are now studying other JAK inhibitors in placebo controlled studies.

While thin hair is nothing to be ashamed of, it's perfectly natural to look for a way to maintain the luscious locks you know and love — and the easiest way to do that is by incorporating the best shampoos for thinning hair into your beauty routine. Whether it's due to stress, hormonal changes, or simply aging, thinning hair and hair loss is something we as women all face at one point or another during our lifetimes. But before we talk about a treatment, let's break down some of the possible reasons behind your thinning hair.


Would there be any harm/benefit in combining the use of two hair-loss prevention shampoos, to take advantage of different ingredients and functions? Mainly Nizoral, at the twice a week recommendation, plus the Argan Oil Shampoo twice a week? I have somewhat oily hair and do get dandruff from time to time, but I do feel after washing my hair, it can feel dry and stiff. Just wondering if a combination of the two (one for dandruff, and one for healthy, thicker hair) might prove effective. Also, would you have any recommendations on a combo? Thanks!
As we wait and anticipate the market release of a new hair treatment there may be times when the waiting gets to us and we feel disappointed, frustrated, and even depressed. This is understandable. However, like many other times in life, a simple change of perspective can lift our mood and positively impact how we feel about a situation. When we look at these companies, are we looking at them as commodities? Are they people who owe you something? Or, are they actually rare groups of folks who are working to bring a gift to your life? How often do you really feel grateful to these companies for the work they are doing?
In essence, it is widely known as Microneedling, and it has the power to completely revive your head and scalp from within. It will, among other things, help rejuvenate your scalp skin, help remove old skin cells and embedded oils (sebum) that are currently blocking and clogging your hair follicles, and most of all, it will reactivate the hair follicles in your head to make them grow hairs again. How amazing is that?
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