Alexey Terskikh PhD of Sanford Burnham Prebys research institute has news to share about his hair follicle research. The Articles page gives you all the highlights on what advancements Terskikh has made over the past three years and when he is planning to take his cloning method to FDA human trials. This is one example of a peer reviewed journal article which actually developed to human translation in a timely manner. Happy Friday
One of the downsides to the product is that you pay hand over foot for all those special ingredients DS packed into this bottle. It’s not the cheap crap that most manufacturers throw into your standard shampoos. It is expensive stuff, and using it daily means there’s no real way of making it last a long time either. The bottom line is you have to bite the bullet but with all the ingredients in this bottle, you’re getting your money’s worth.
SM04554, Samumed’s topical for androgenic alopecia, is one of the company’s late stage programs. The other late stage program within Samumed is their drug for osteoarthritis. Phase 3 trials are very costly so the numbers here make sense for Samumed to be pushing forward. This news would indicate we should be hearing about Samumed initiating a phase 3 trial for the commercialization of SM04554 in the near future.
For hair transplant clinics, this is the ultimate goal. Bald people would make a mad dash to their clinics to get their new heads of hair. Since the main limitation of hair transplantation surgery is how many hairs can be harvested from the back of the scalp before it appears thin, stem cloning (the growing of dermal papilla cells) will solve that problem in totality. Recent research that has taken place in California has taken a big step toward the cure for hair loss.
Hey there, I'm Shawn, the founder of Tools of Men! This site was created to help out other guys by teaching them proper grooming habits and the basics of sensible style. We try to make things here a bit of fun while giving you clear info. If you want to get in touch with us, drop us a line on the contact page or via social media. Thanks for checking out the site - and make sure to come back again!
In this simple, step-by-step book, I will reveal how to use a dermaroller to get new hair growth, a natural hair loss cure that helped me re-gain my old hair line, that doesn't involve any fancy drugs like minoxidil. In fact, all you really need in order to achieve the same results like me is a few basic ingredients that you can easily find online.
Once male-pattern baldness starts, it’s not going to stop until every last hair on your head has shrunk or shed, though the rate at which this happens differs from person to person and depends on genetics. And since the grind of hair loss is unending, it’s important to start treatment as soon as your hairline starts bothering you. If you’re looking for a more quantitative metric, Dr. Paul McAndrews, clinical professor of dermatology at the USC School of Medicine and member of the International Society of Hair Restoration Surgery, assures me that “you have to lose half your hair before the human eye can tell.” (Of course, if you don’t care about losing your hair and are fine with going full Prince William and shaving your head, go for it. We’ve got some recommendations for razors and hair trimmers to help you out on that front.)

Thanks so much for the guidance! After further research I have to agree with you 100%. Lipogaine Big 3 does containe ketoconazole, which would eliminate the need for Nizoral, however the shampoo only contains a few hair loss/thinning related ingredients. The Big 5 contains 17 and just seems like a better overall product. That plus Nizoral twice weekly seems pretty solid to me.
Cloning has seen many false starts and wrong turns, Christiano told me. Now her team is building “an artificial skin with a dermis and an epidermis, with molds made to mimic the dimensions of hair density,” she explained. “When the artificial skin matures we pull out the pre-formed hairs and insert them into the skin.” Bernstein is convinced that, in the next ten years, cloned hair will happen. “And then the supply and demand problem is solved,” Bernstein said. “Without Bernanke!”
Anagen effluvium is usually reversible, with regrowth one to three months after cessation of the offending agent. Permanent alopecia is rare. A large meta-analysis of clinical trials concluded that scalp cooling was the only intervention that significantly reduced the risk of chemotherapy-induced anagen effluvium.27 However, scalp cooling should be discouraged because it may minimize delivery of chemotherapeutic drugs to the scalp, leading to cutaneous scalp metastases.27
Dr. Carlos Wesley, a hair restoration surgeon in Manhattan, said that women in his practice respond better to P.R.P. than men do, which may have something to do with the fact that women with genetic hair loss tend to have more inflammatory cells around the follicles. From 2013 to 2014, he said, he had an 83 percent increase in female patients, in part because of P.R.P.
The follicles on the sides of the scalp are more genetically resistant to DHT, which is why male pattern baldness often results in a “crown” of hair. But its downsides are serious. “With women, finasteride is not an option,” says Dr. Wolfeld. “It’s not FDA-approved for women to take, so we don’t prescribe it.” In fact, due to the drug’s effect on hormone levels, pregnant women are advised to not even touch broken or crushed tablets.
A little something for you all to nibble on. I’ve recently discovered a stem cell therapeutic company who has an interest in putting out cosmetic hair growth products. The company, Stemedica, is working on treating a wide range of diseases through clinical stem cell therapies. I counted 6 clinical trials in progress on their pipeline page. Perhaps more interesting for this audience, the company is also developing skin and hair growth cosmetic products from their core stem cell technology. Stemedica has a specific subsidiary in place to roll out dermatology cosmetics called StemCutis. Their website mentions the use of stem cell-derived growth factors to to be used in the products. It’s not clear what stage of development the hair growth product is at, but it’s good to have it listed in Stemedica’s sights. 
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HCell Inc. announced this week in a press release the addition of two new members to its Board of Directors. Robert P. Ryan PhD and Marlene Haffner MD PhD comprise the additions to the Board. HCell mentions in the release that the respective additions will be supportive to HCell through their combined experience in orphan drug development and FDA regulatory processes.
Besides cost considerations, a hair transplant is generally prescribed as a last resort for permanent hair loss problems. It is also not allowed for people under the age of 25, those with a continuing problem of hair loss, as well as those with other health conditions like uncontrolled diabetes, serious heart problems and hypertension. Patients whose hair loss is caused by other factors, such as a skin or scalp disorder or who suffer from a psychological condition that causes them to pull at their hair are not recommended for this procedure. Since the procedure requires taking a sample from the back of the head, those who do not have enough follicles from this section that can be used for transplant are not also eligible.
Unfortunately nutritional supplements are hit and miss. While the risks of side effects go down which is attractive, clinical data is sparse. In most cases the individual has to conduct their own experimentation. At 6 months a pop for a fair trial, this is a time consuming process. Time is a very limited commodity especially in the hair loss game. As we know, it is easier to do preventative maintenance than reverse hair loss. Nevertheless, natural DHT inhibitors like saw palmetto and nettle have worked to prevent hair loss in some users.
The main type of hair loss in women is the same as it is men. It's called androgenetic alopecia, or female (or male) pattern hair loss. In men, hair loss usually begins above the temples, and the receding hairline eventually forms a characteristic "M" shape; hair at the top of the head also thins, often progressing to baldness. In women, androgenetic alopecia begins with gradual thinning at the part line, followed by increasing diffuse hair loss radiating from the top of the head. A woman's hairline rarely recedes, and women rarely become bald.

The Holy Grail remains a drug that will promote regrowth, but this might not be so far away. Earlier this year, Manchester University announced that an osteoporosis drug had been found to have “dramatic results” promoting hair growth when applied to tissue samples in pre-clinical trials. The resultant frenzy left the PhD student responsible, Dr Nathan Hawkshaw, a little dazed. “Every other week, something comes out about hair loss and it doesn’t generate as much media coverage as what I experienced,” he grumbles. He’s in this for the science – there aren’t many fields where you get to mess around with real human tissue – but such is the distress caused by hair loss and such is the potential customer base that interest is always high.
Chemotherapy is also one of the primary causes of balding among cancer patients, men and women alike. While not all chemotherapy treatments result in hair loss, some that involves the use of drugs like Altretamine, Carboplatin, Docetaxel, and Idarubicin can cause hair thinning and hair fall. In such cases, the hair loss varies from person to person and the dosage of drugs administered. Hair fall doesn't occur at once, but rather after several weeks of treatment until hair fall rate increases after one or two months of exposure to chemotherapy. Radiation therapy as part of cancer treatment can also result into hair loss but typically only in areas where the radiation is targeted.

Originally spotted this on HairLossCure100’s twitter page. Concert Pharmaceutical’s therapy for alopecia areata, CTP-543, has been granted fast track designation from the FDA. CTP-543 is an oral JAK inhibitor (ruxolitinib). From what I’ve read, fast track designation encourages early and frequent communications between the FDA and the company during the development process to ensure issues and questions are resolved quickly.
Jimenez, J. J., Wikramanayake, T. C., Bergfeld, W., Hordinsky, M., Hickman, J. G., Hamblin, M. R., & Schachner, L. A. (2014). Efficacy and Safety of a Low-level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-controlled, Double-blind Study. American Journal of Clinical Dermatology, 15(2), 115–127.
Pura d’or also have a hair loss conditioner compliment to this shampoo but we think it’s a bit overkill to use both(as a bottle of this stuff runs on the pricey side)—but if you love the shampoo the conditioner is also a very popular product that couldn’t hurt. Leave it in for about 3 minutes and let your scalp absorb all those vitamins and minerals.
Finasteride has limitations though, such as the requirement of daily treatment, a limit to how many damaged hair follicles it can revive, and that it may lose its effectiveness overtime for some people. This drug has shown to be better at preventing further hair loss than reversing it (regrowth). Just keep in mind that some side effects might make the hair loss seem more appealing. 

After the groundbreaking 1999 study on mice, some researchers were mildly optimistic that SHH activation could also have positive implications on human hair growth in balding men and women. A new company that was formed in 2000 called Curis partnered with Procter & Gamble in 2005 to try and develop a topical Hedgehog agonist product for scalp hair growth.
Signage for Shiseido Co. is displayed outside the company's headquarters in Tokyo, Japan, on Friday, Feb. 28, 2014. Shiseido, Japan's largest cosmetics maker, is under reform after posting losses due to weak domestic sales and an impairment loss on goodwill associated with Bare Escentuals, which it bought in 2010. Photographer: Kiyoshi Ota/Bloomberg
“The most common cause of hair loss in both men and women is androgenetic alopecia, which is genetic pattern hair loss,” explains Dr. Michael B. Wolfeld, a board-certified plastic surgeon and an assistant clinical professor of plastic surgery at the Icahn School of Medicine at Mount Sinai Hospital in New York. The root cause of this type of hair loss is dihydrotestosterone (DHT), a byproduct of testosterone that shrinks certain hair follicles until they eventually stop producing hair.

Hair multiplication. Similar to the idea of cloning, this treatment involves taking out donor cells from the hair follicles and then growing and multiplying them in a laboratory. Once sufficient samples have been multiplied, these hair cells are then injected into the bald patches to stimulate hair growth. As a relatively new treatment, hair cloning is still in its research phase.


3. Scalp tonic. Serums with peptides or procyanidins (a class of antioxidants) such as niacinamide can help support overall scalp health and reduce inflammation, which is a major component of hair loss, says New York City dermatologist Doris Day. Try René Furterer Triphasic Progressive Concentrated Serum ($82), Julien Farel Magnifique Delay the Gray Hair & Scalp Serum ($135), or Day’s own Rapid Regrowth Serum ($55) once daily before massaging a minoxidil product into the scalp (there’s no need to wait for it to dry in between). “In addition to being anti-inflammatory,” Day says, “scalp tonics help minoxidil penetrate the scalp better and can minimize potential irritation from it.”
Blow dryers, flat irons, and other devices: Frequent use of a blow dryer tends to damage hair. The high heat from a blow dryer can boil the water in the hair shaft leaving the hair brittle and prone to breakage. Dermatologists recommend that you allow your hair to air dry. Then style your hair when it is dry. Dermatologists also recommend limiting the use of flat irons (these straighten hair by using high heat) and curling irons.
The thing is that these big drug companies have shelled out millions and even billions of dollars to research, develop, market and then sell a drug-based product that consumers want. Therefore, they will do everything in their power to protect and guard their products against any drug-free alternatives. The kicker is even if said alternatives are cheaper and safer for consumers, while also achieving the same goals for them! This is the crux of claim enforcement, which is really about claim ownership and claim protection from the perspective of the big drug companies.
Yet another company has made news this week for phase 2 trial progress. Concert Pharmaceuticals announced today that they have completed enrollment for their phase 2a trial using CTP-543 in alopecia areata. CTP-543 is an oral JAK inhibitor which acts on JAK 1 and 2, it’s also known as ruxolitinib. Concert’s version of ruxolitinib has been modified by the company’s proprietary deuterium chemistry technology which the company hopes will improve its effects on AA.
A number of other shampoo and conditioner products are available that seem to be very popular with men and women suffering from thinning hair. These include a range of Shapiro MD and Nioxin hair loss shampoos. Also popular are Keranique and the uniquely named Bumble and Bumble thickening shampoo. Some of these do not have a sufficient number of reviews for me to consider adding them to my list of top shampoos.
A popular skin care drug—which is intended to target eczema—was just found to have an unusual side effect: hair growth. According to an article on Newsweek, the FDA-approved drug dupilumab was given to a 13-year-old alopecia sufferer to treat her eczema. The patient, who hadn’t grown hair on her scalp since she was two, suddenly grew a significant amount of hair on her head after continual use of the drug, a study in the journal JAMA Dermatology reports.
Researchers from South Korea have identified a new peptide called PTD-DBM which exhibits wound healing and hair regeneration effects in preclinical studies. The research is being led by Professor Kang-Yell Choi of Yonsei University. Choi’s team identified the peptide PTD-DBM which targets a protein called CXXC5. The interaction of these two proteins leads to stimulation of the Wnt pathway, which then initiates hair follicle neogenesis. Choi hopes to develop this peptide further into a potential hair growth drug candidate. A research paper about these findings was put out by the team earlier this year. Source article about this development here.
This shampoo has one of the top ratings of any shampoo sold online. KIMI Naturals must be doing something right! Saw palmetto, biotin, argan oil, and keratin are some of the highlight ingredients in this shampoo. They offer a 60 day money back guarantee, so if you’re not happy with the results after you give it a go, get you’re money back. On their KIMI Naturals website, they also sell a vitamin supplement and scalp treatment which they sell together with this shampoo as a 3-pack system.

Hair concealers and hair fibers. These are one of the newest cosmetic answers to hair loss. As the name suggests, these products are applied on the scalp or hair to camouflage hair loss and give the appearance of fullness to thinning hair. Some of these are applied directly on the scalp, while others (hair fibers) are attached to the hair, much like hair extensions, to add volume.
The dermatologist also will carefully look at your scalp and hair. During an exam, the dermatologist may pull on your hair. Sometimes a dermatologist needs to pull out a hair to get the necessary evidence. And sometimes a dermatologist needs to look at the hair on the rest of your body to see whether there is too little or too much hair in other areas.
A healthy scalp might be your ticket to improving overall fullness and density. Nioxin’s cleanser rinses away excess sebum, fatty acids, and other disruptive scalp residue, while also coating strands with BioAMP, a signature blend of amino acids and conditioners that aim to thicken and repair damaged hairs. “This is the best thing I've tried for my hair,” one Ulta reviewer commented. “It's very thin (genetics) and used to fall out in (what I'd call) clumps. I'm not seeing anywhere near as much hair all over the furniture, floor, sink, clothes. It's fabulous.”

Unfortunately, as of now the video is only available on BCC Newsbeat for people living in the UK. I haven’t been able to watch it yet but am searching for a solution for those of us abroad to view the episode. One of the personalities featured in the film, Perry O’Bree, has created an interesting Youtube Video promoting the message that #HairLossHappens and that those who experience it are not alone. I find it to be a courageous and uplifting message. The topic often is often overlooked and understated, and the truth is that hair loss is much more of an important issue than how it is portrayed in society. Kudos to Perry.
Anagen effluvium is usually reversible, with regrowth one to three months after cessation of the offending agent. Permanent alopecia is rare. A large meta-analysis of clinical trials concluded that scalp cooling was the only intervention that significantly reduced the risk of chemotherapy-induced anagen effluvium.27 However, scalp cooling should be discouraged because it may minimize delivery of chemotherapeutic drugs to the scalp, leading to cutaneous scalp metastases.27
How about if you’d rather not get your head punctured? In Sweden, a company called Follicum is now doing Phase IIA clinical studies and planning to communicate results by the end of the year. The end product will be a cream or a lotion, one that could be applied as few as three times a week. In the first trial, Follicum claims, more than seventy-five per cent of patients experienced hair growth. This is the real dream, the one so artfully captured in the Hims ads: pop a pill, slap on some cream, and get Hair God locks.
However, each formula contains a different mix of ingredients and will act on preventing the hair loss process in a unique way. Perhaps one of the best things about these anti DHT shampoos is that they are mostly natural and organic compositions with little to no side effects. Probably your biggest risk in using one of these shampoos is a red or itchy scalp, which typically goes away after a couple hours following your shower.
In II Kings 2:23-24, the prophet Elisha is mocked by a gang of surly kids. The kids “said unto him, ‘Go up, you bald head! Go up, you bald head!’ ” Elisha “cursed them in the name of the Lord.” Promptly “two she-bears came out of the wood and tore forty-two of them.” Sometime later—in 2013—German researchers published a study indicating that men experienced hair loss as an “enormous emotional burden” that could lead to an “impaired quality of life” and “psychological disorders.” Inversely, one study has shown that people perceive men with bountiful hair as likely having big penises.
In-office laser light treatments or at-home handheld devices, such as the HairMax LaserComb, supposedly grow new hair by stimulating blood flow to the area (think: an amped-up version of a scalp-stimulating shampoo). Just don’t expect the device to make your noggin go from looking like George Costanza’s to Jerry Seinfeld’s. “These lasers won’t grow any new hair. If anything, they may just help you hang on to some of the hair that you already have a bit longer,” says Dr. Joyce.
Of course, there are plenty of men who wish desperately to restore their youthful locks, and a few — we can think of one powerful one — who cling to elaborate comb-overs, but many balding men simply clip their hair short and go on with their lives. Dermatologists say hair loss is emotionally harder for women, who are often deeply embarrassed by thinning hair even though it's quite common. By the time they reach 50, about 40 percent of women are experiencing what's known as female-pattern hair loss, said Gopal Patel, a dermatologist with Aesthetic Dermatology Associates in Media. Women of African descent struggle with even more conditions that can damage hair follicles and cause bald spots.
Where is the bald spot? What exactly are the dimensions of this bald spot? It’s all so stupid, so tiringly stupid. In May, Trump’s former personal physician, Harold Bornstein, revealed that Trump had sent people to seize all of his personal health records. Bornstein called it a “raid” that left him feeling “raped, frightened, and sad.” He also claimed that it was revenge for having revealed to the media that Trump was on Propecia.
Hair multiplication. Similar to the idea of cloning, this treatment involves taking out donor cells from the hair follicles and then growing and multiplying them in a laboratory. Once sufficient samples have been multiplied, these hair cells are then injected into the bald patches to stimulate hair growth. As a relatively new treatment, hair cloning is still in its research phase. 

Since PhytoCayne Revitalizing shampoo is so watery, it’s easy to overpour and waste a good amount of this expensive product. That’s one reason we rank it below Revivogen and Nioxin. The more important reason for the #3 ranking is that this shampoo doesn’t do everything that the other two products do. It’s still effective for most users, however, and worth a try. 

Dr. Carlos Wesley, a hair restoration surgeon in Manhattan, said that women in his practice respond better to P.R.P. than men do, which may have something to do with the fact that women with genetic hair loss tend to have more inflammatory cells around the follicles. From 2013 to 2014, he said, he had an 83 percent increase in female patients, in part because of P.R.P.

“No probs. If you come across any other documentaries in the UK that you cannot view in the States feel free to ask me to watch it and feedback. I think sites like yours give people an incentive to keep looking forward with some optimism. Without doubt a feasible hair loss solution isn’t far away. I think it will most likely be a next gen hair transplant through hair cloning. But what ever it might be, as you said in a previous comment there have never been as many players in the hair loss industry. There will be a few false starts, but one, quickly followed by others will come through. It’s just the wait 🙁 But you never know with Shiseido, Brotzu and Haircell releasing data this year it could be sooner than we think 🙂 Kind regards” – Welsh Dragon
Baldness is not caused by excess testosterone as is commonly thought; nor is it inherited from your maternal grandfather. It’s caused by sensitivity to testosterone: an enzyme converts testosterone into a substance called dihydrotestosterone – which then causes the follicle to shrink and fall out. Male pattern baldness is inherited, but from both or either side of your genetic line. Why men go bald, we’re not sure – though there is a hypothesis that baldness was once a genetic advantage. People tend to associate baldness with virility and wisdom. The bald hunter-gatherer would have been a natural choice for a chieftain back when life expectancies were shorter and bald heads rarer. In our age of appearances not so much. Of 17 male members of Cabinet, two are bald (Chris Grayling and Sajid Javid). Studies correlate baldness with depression; the term “psycho-trichological” is used to describe the feelings of disfigurement, social avoidance and anxiety disorders that often arrive with premature baldness.

After the robot was done, two nurses picked off the skin grafts and hairs and put them in petri dishes. While they prepared them for implantation, Bernstein explained the real future of the business: cloning. Bernstein has partnered with a Columbia University geneticist, Angela Christiano, who is working on duplicating hairs. The problem with hair transplantation is that you’re moving hairs around, not creating new ones. Women affected by female-pattern hair loss, in particular, are left out: they don’t have a thick back patch of “donor hair” to work with.
Finasteride (brand name Propecia) is the closest to a hair loss cure pill that scientists have discovered to date. This is a DHT hair loss cure. DHT is made when 5 alpha reductase converts testosterone, and Propecia has been found to be an effective inhibitor of DHT by preventing this process from happening. It works internally, at the root of the cause. Therefore, DHT sensitive hair follicles in the front and top of the scalp don’t have to fight off nearly as much DHT.
Dry, brittle strands—whether from heat damage or age—can definitely cause your hair to thin out. With more than 5,000 verified customer reviews, the Pura D’or Gold Label Shampoo gets top marks for its restorative, regenerative, and strand-strengthening properties. Among the shampoo’s 17 active ingredients are red Korean seaweed, which is proven to treat alopecia, and scalp-stimulating black cumin seed oil.
“I also reached out to Histogen and Follicum a few weeks ago as well thanking them for all their hard work in bringing a safe and effective treatment to people all over the globe with hairloss issues and expressed how much we all value these companies. I held back from asking about market release as you had suggested. I received a very nice reply from Histogen.”
Nizoral is the gold-standard in hair loss prevention. Its main ingredient is ketoconazole. The nice thing about Nizoral is that you only need to use it twice a week (because ketoconazole binds to the proteins in your hair so it will keep working many days after use). If you were to use it daily your scalp would be drier than a desert and itchy as all heck.
Iron supplements. Iron deficiency could be a cause of hair loss in some women . Your doctor may test your blood iron level, particularly if you're a vegetarian, have a history of anemia, or have heavy menstrual bleeding. If you do have iron deficiency, you will need to take a supplement and it may stop your hair loss. However, if your iron level is normal, taking extra iron will only cause side effects, such as stomach upset and constipation.
What’s got less evidence supporting its efficacy are the hair-growth shampoos that claim to block DHT (like those sold by Hims in their Rx Hair Kit). Rieder is skeptical that you’re going to see any tangible benefits by rubbing DHT blockers into your scalp. “I find it very difficult to believe that something that’s applied to the scalp and rinsed off is going to have any appreciable effect.” All four doctors also shut down any suggestions that hair-growth supplements or vitamins, like biotin, could help promote hair growth or stop hair loss — though a couple hypothesized that vitamins or supplements could lead to hair regrowth if your hair loss was a result of a nutritional deficiency. But otherwise, if you’re dealing with regular old male-pattern baldness, “There is no such thing as a ‘hair vitamin,’” says McMichael.
Follicum announced yesterday it has successfully completed the development of a topical formulation for FOL-005. The company had been working in parallel to develop an optimal topical version of FOL-005 while an injectable version of the peptide was being used in a clinical trial. Now that the topical formula is completed it will be trialed in a further phase 2 clinical trial which will likely begin very late 2018 or early 2019.
Follicle Thought is interested in connecting with scientists and startups who are working on hair growth or hair loss prevention research. If you or a colleague is working on hair growth please get in touch on the Contact page, even if you are not ready to share news on the site yet. Follicle Thought can offer networking and other resources to benefit your development. Thanks

During this procedure, surgeons remove a narrow strip of scalp and divide it into hundreds of tiny grafts, each containing just a few hairs. Each graft is planted in a slit in the scalp created by a blade or needle in the area of missing hair. Hair grows naturally this way, in small clusters of one to four follicles, called follicular units. As a result, the graft looks better than the larger "plugs" associated with hair transplants of yesteryear.
MAX BioPharma, a company working with Hedgehog pathway therapeutics, wants to test its lead compound for hair growth in  mouse model. If data from this experiment turns out to be positive the company says it will reach out to cosmetic or larger pharma partners to commercialize the product. While we currently don’t know how this therapy will fare for hair growth, in the past we have seen impressive potential from stimulators of the Hedgehog pathway.
Alopecia areata. This condition, called patchy hair loss, is the opposite of pattern baldness. Whereas in the former, thinning hair follows a pattern, alopecia areata is marked by smooth and bald patches anywhere on the scalp. The bald patches are circular, and can be as small as a pencil eraser or as big as a quarter. It begins with one or two spots that multiply on other parts of the head. The condition is caused by an autoimmune disease where the antibodies mistake the hair as the "enemy" and start attacking it, resulting into hair loss.
Though, it is important to point out that a lot of these companies are developing procedures that involve implanting hair, which means there is a chance they will be expensive — as we mentioned before, traditional hair transplants are costly. But a few companies and products such as Follicum’s FOL-S-005 and Fidia Pharma’s Brotzu Lotion are being designed as topical treatments. 
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