I have only used this twice, but in that short time of use, I believe my hair shedding has increased. In fact, immediately following the last use my hair seemed to be coming out more than I had seen prior to ordering the shampoo at all. Experiencing hair loss, thinning, or excessive shedding (especially for a woman) can be very distressing, and to purchase a product in hopes that it will help to curb or even reverse the issue only to find it exacerbates the problem is INCREDIBLY stressful. I was hopeful about this product, given the overall reviews, but I'm afraid to use this product even one more time, for fear of making my hair loss worse.

Jimenez, J. J., Wikramanayake, T. C., Bergfeld, W., Hordinsky, M., Hickman, J. G., Hamblin, M. R., & Schachner, L. A. (2014). Efficacy and Safety of a Low-level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-controlled, Double-blind Study. American Journal of Clinical Dermatology, 15(2), 115–127. 

The most popular low-light laser therapy product is developed by Hairmax. They have a series of Hairmax Laser Combs. Treatment is applied weekly or more frequently. Notably, the Hairmax Laser Comb was the 3rd product to receive FDA approval for treatment of genetic balding. It followed Minoxidil and Finasteride. Though some scalps are very responsive to this laser treatment, others seem to only reap the benefit of slowing hair loss. Another downside is that each treatment session takes about 15 minutes, where the laser comb must be directed towards thinning and bald areas. Unless you have a handy device such as the one in the image, you stuck doing things manually.

In most cases though, it's all a matter of attitude. Being bald should not be a cause of stigma. It does not make you less of a person or less masculine, less virile, and less attractive and appealing. In fact, a clean shaven head is becoming a popular trend among men these days, and there are certainly many bald men who have managed to make themselves look clean, elegant and suave despite their hair loss. Learn to come to terms with it. It's hair loss, yes, but not brain damage. It does not affect your core.
While the drug is generally safe for use, some possible side effects are mild irritation of the scalp, dryness and growth of hair on some parts of the body, especially the sides of the face and hands. In some cases, you might observe some increased hair loss around the first few days of use. If the hair fall continues after two weeks upon application of minoxidil, stop the treatment first and see a doctor.
Key features: The Dove Dermacare anti-dandruff 2-in-1 shampoo and conditioner is a solid option for dandruff management that's also super affordable. For $15, you'll get not one, but two bottles. Its active ingredient is pyrithione zinc, an anti-fungal ingredient commonly used to treat psoriasis that Dr. Zeichner recommendeds for dandruff. The formula is effective in treating scalp dryness and flakes because of it, and it has a refreshing mint scent.
For those of you who only check the Updates page, there was a new Brotzu Check-In article published yesterday. Giovanni Brotzu will be presenting data pertaining to his lotion’s use in androgenetic alopecia at an Italian hair research Congress this Saturday, April 14th. We hope to see photo results from the presentation. Check back to the Brotzu article next week for updates.
Laser therapy is available in salons and administered by a hair professional who has been trained in the procedure. Treatment is usually two to three times a week. Generally, each session involves a short 8-15 minute exposure of the scalp to the laser device. There is generally no prescribed period of time that the treatment should be administered, although the more frequent and longer the duration, the more effective results have been observed. Noticeable hair growth can be observed after 12 to 26 weeks of treatment. The LLLT is also prescribed as a complementary treatment in post-operative hair surgery.
Laser devices: Brushes, combs, and other hand-held devices that emit laser light might stimulate hair growth. These devices might make hair look more youthful in some people. Because the FDA classifies these products as medical devices, the products do not undergo the rigorous testing that medicines undergo. The long-term effectiveness and safety for these devices are not known.
The average person loses 50 to 100 hairs per day naturally due to this cycle. But if the process is interrupted at any stage—for example, if the follicle doesn’t come back out of resting mode or starts to shrink—hair loss and hair thinning can result. Interruptions to the cycle can be caused by hormones, stress, poor diet, chemical hair treatments, certain medications, and, of course, good ol' genetics. 

A clinical researcher who has spent decades researching the fields of pattern hair loss, alopecia areata, endocrinology of the hair follicle and hair follicle morphogenesis, Hoffmann works in his private practice, as a teaching professor in the Department of Dermatology at the University of Marburg and as a researcher on histopathology on hair diseases. He has participated in dozens of clinical hair studies and is the inventor of TrichoScan®, a computerized technique to measure hair growth.
Another shampoo which is part of a “system” that includes conditioner and serum. And it’s yet another shampoo which has worked well on its own for many people. The HairGenesis shampoo (and the other products) contains a proprietary formula that is patent-pending, and the company says that the goal of the shampoo is to prepare hair for “maximum growth potential.” It also uses a lot of impressive sounding phrases to describe what the HairGenesis shampoo does.
Choose the right shampoo based on its healthy and all-natural active ingredients, such as those found in Veta. These products do work on your thinning and shedding hair. And if you’re wondering, “How fast will I regrow hair with a hair growth shampoo?” Well, that again depends on the cause of your hair loss: genetics, lifestyle choices, environmental triggers, etc... but also on the product’s composition and concentration of active ingredients. Veta has the highest concentrations of both follicusan and trichogen, which is why Veta products work.
"Others are taking hair follicles out of human scalp and growing them with dermal papilla cells," Cotsarelis says. "If they grow in culture, you might be able to recombine them with skin cells and form new follicles. This would let you expand the number of follicles you get for a hair transplant. This may not be that far off -- five to 10 years, maybe. There's very good evidence you will be able to do that."
Researchers from UCLA in the lab of Jing Huang have recently shown that certain molecules which activate the cellular process known as autophagy also drive hair follicles into the anagen (growth) phase. The researchers studied different metabolite molecules and other molecules which are FDA approved and on the market as drugs. The most recognizable drugs from the study were metformin and rapamycin, one is a diabetes medicine and the other an immunosuppressant. Dr. Huang says her lab is looking to study these drugs for human hair growth soon. In my opinion, results from that study are something to look out for. Full article on the Articles page.
In this section we take a look at current hair loss cures in 2018. Using one or more of the treatments below is your best shot at keeping your hair around. However, if a cure is defined as a permanent fix to an ailment, these are far from that definition. Each of these treatments have their own limitations. Most are seen more as hair loss management treatments, rather than permanent hair loss cures.
Unfortunately, as of now the video is only available on BCC Newsbeat for people living in the UK. I haven’t been able to watch it yet but am searching for a solution for those of us abroad to view the episode. One of the personalities featured in the film, Perry O’Bree, has created an interesting Youtube Video promoting the message that #HairLossHappens and that those who experience it are not alone. I find it to be a courageous and uplifting message. The topic often is often overlooked and understated, and the truth is that hair loss is much more of an important issue than how it is portrayed in society. Kudos to Perry.
Unfortunately nutritional supplements are hit and miss. While the risks of side effects go down which is attractive, clinical data is sparse. In most cases the individual has to conduct their own experimentation. At 6 months a pop for a fair trial, this is a time consuming process. Time is a very limited commodity especially in the hair loss game. As we know, it is easier to do preventative maintenance than reverse hair loss. Nevertheless, natural DHT inhibitors like saw palmetto and nettle have worked to prevent hair loss in some users.
The Holy Grail remains a drug that will promote regrowth, but this might not be so far away. Earlier this year, Manchester University announced that an osteoporosis drug had been found to have “dramatic results” promoting hair growth when applied to tissue samples in pre-clinical trials. The resultant frenzy left the PhD student responsible, Dr Nathan Hawkshaw, a little dazed. “Every other week, something comes out about hair loss and it doesn’t generate as much media coverage as what I experienced,” he grumbles. He’s in this for the science – there aren’t many fields where you get to mess around with real human tissue – but such is the distress caused by hair loss and such is the potential customer base that interest is always high.
Originally spotted this on HairLossCure100’s twitter page. Concert Pharmaceutical’s therapy for alopecia areata, CTP-543, has been granted fast track designation from the FDA. CTP-543 is an oral JAK inhibitor (ruxolitinib). From what I’ve read, fast track designation encourages early and frequent communications between the FDA and the company during the development process to ensure issues and questions are resolved quickly.
Another shampoo which is part of a “system” that includes conditioner and serum. And it’s yet another shampoo which has worked well on its own for many people. The HairGenesis shampoo (and the other products) contains a proprietary formula that is patent-pending, and the company says that the goal of the shampoo is to prepare hair for “maximum growth potential.” It also uses a lot of impressive sounding phrases to describe what the HairGenesis shampoo does.

The main type of hair loss in women is the same as it is men. It's called androgenetic alopecia, or female (or male) pattern hair loss. In men, hair loss usually begins above the temples, and the receding hairline eventually forms a characteristic "M" shape; hair at the top of the head also thins, often progressing to baldness. In women, androgenetic alopecia begins with gradual thinning at the part line, followed by increasing diffuse hair loss radiating from the top of the head. A woman's hairline rarely recedes, and women rarely become bald.
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I also reached out to Histogen and Follicum a few weeks ago as well thanking them for all their hard work in bringing a safe and effective treatment to people all over the globe with hairloss issues and expressed how much we all value these companies. I held back from asking about market release as you had suggested. I received a very nice reply from Histogen.


Coconut milk / coconut oil. Coconut milk/oil, like aloe vera, is one of the oldest and most common natural ingredients for promoting hair growth and growing healthy, shiny hair. Coconut is rich in protein, iron and other minerals that promote healthy hair and prevent breakage. Apply the coconut milk/oil on your bald spots or all over the scalp, and leave it on overnight. Rinse the next day with cool water. You can do this every time you wash your hair.
The researchers from the University of Manchester’s Centre for Dermatology Research uncovered this finding through lab tests. They used samples containing scalp hair follicles from more than 40 male hair-transplant patients. The hair follicles were placed in a medium and treated with the drug. Researchers said that those hair follicles were able to grow again because it suppressed the actions of SFRP1.
Our panel of five people was unanimous in their choice – Shapiro MD. Developed by two leading dermatologists this patented formula has been proven to fight and even reverses hair loss in both men and women.  While some testers found the smell a bit herbal the overall consensus was that it was a fantastic color-safe shampoo and a moisturizing conditioner. In addition, we found their customer service was excellent and they honored their 60-day guarantee.  Shapiro MD designed their shampoo and conditioner with pharmaceutical-grade ingredients.  Shapiro MD’s mission is to develop health and beauty products using only clinically tested ingredients.
JW Pharma, a Korean biotech company that specializes in the Wnt pathway, has entered a cooperative agreement with the University of Pennsylvania to development a compound called CWL08006 for hair regeneration purposes. JW Pharma has a pool of Wnt targeting therapies, and apparently CWL08006 makes a great candidate for hair growth. Of course, Dr. George Cotsarelis of UPenn is involved, and the two teams plan to begin preclinical testing by 2019 (I’m a little surprised at that timeline for preclinical). One of the more interesting facets of the report, JW intends “to accelerate its commercialization by launching tests on the human body for cosmetics that utilizes the drug’s mechanism, next year.” If the candidate works well in the cosmetic tests, a version of it could be made available much sooner than the clinical drug pathway, but for now it’s not possible to speculate a time frame for that yet. Good news all in all. 
From the top of my head, I don’t remember if the Lipogaine’s Big 3 Shampoo contains ketoconazole but if it does, then that’s a definite plus. Another thing you can do is buy Nizoral and use it in conjunction with The Big 5 Shampoo. So for example, use Nizoral on Mondays and Thursdays and The Big 5 in all the days in between. That way you’d get all the benefits.
Managing hair loss is just as important as treating it. Now that we've talked about the different treatment options and cures available to reverse hair loss and promote increased growth, let's talk about how you can manage your condition and at the same time prevent further hair loss. The first is more psychological, while the second is more practical.
While the drug is generally safe for use, some possible side effects are mild irritation of the scalp, dryness and growth of hair on some parts of the body, especially the sides of the face and hands. In some cases, you might observe some increased hair loss around the first few days of use. If the hair fall continues after two weeks upon application of minoxidil, stop the treatment first and see a doctor. 

More good research coming from the University of Alabama at Birmingham shows that a certain gene affecting mitochondrial function can dramatically reverse signs of aging in mice. The aging factors which were shown to be reversible include skin wrinkles, gray hair, and hair loss. Next comes the important phase where the researchers continue forward to translate this discovery to human use. Full article on the front page.
When it comes to a hair growth shampoo, you have two options: prescriptions or over-the-counter treatments. Prescription shampoos like ketoconazole are anti-androgenetic, meaning they prevent testosterone and dihydrotestosterone (DHT), two hormones associated with hair loss by targeting hair growth at the site of the follicle and helping to interrupt the hormone cycle locally that causes thinning,” explains Dr. Schweiger. “Over-the-counter growth shampoos typically contain amino acids and antioxidants to provide the components to rebuild hair as well as reduce damage and inflammation.”
The combination of silent suffering, public shame and poorly understood science makes hair loss sufferers easy prey – type “hair loss” into Google and you’ll see what I mean. Kobren tells me that he had to remove the personal messaging function on the Bald Truth message board, as users were being bombarded by scams. Meanwhile, the higher visibility of celebrity transplants means that baldness is at risk of being seen as a sign of poor self-care. Many treat surgery lightly – and enter into punitive financing deals. One of Kobren’s recent guests was The Only Way is Essex star Maria Fowler, who complained that surgery at the controversial KSL Hair in Glasgow left her with an unnatural hairline. “She ended up having a hair transplant because her fiancé was having one. She had always thought her hairline was too high. She went in like she was having her nails painted – and it destroyed her life.”
A clinician diagnoses female pattern hair loss by taking a medical history and examining the scalp. She or he will observe the pattern of hair loss, check for signs of inflammation or infection, and possibly order blood tests to investigate other possible causes of hair loss, including hyperthyroidism, hypothyroidism, and iron deficiency. Unless there are signs of excess androgen activity (such as menstrual irregularities, acne, and unwanted hair growth), a hormonal evaluation is usually unnecessary.
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Telogen effluvium is a nonscarring, noninflammatory alopecia of relatively sudden onset, with similar incidences between sexes and age groups. It occurs when large numbers of hairs enter the telogen phase and fall out three to five months after a physiologic or emotional stressor. The list of inciting factors is extensive and includes severe chronic illnesses, pregnancy, surgery, high fever, malnutrition, severe infections, and endocrine disorders. Causative medications include retinoids, anticoagulants, anticonvulsants, beta blockers, and antithyroid medications; discontinuation of oral contraceptive agents is another possible cause.17
Things get interesting when we discover a patent which was filed by Sangamo in May 2017 titled “Targeted Treatment of Androgenic Alopecia.” As with virtually all patents, the lengthy text of the patent is difficult to read or to create a concise summary from. An intriguing aspect of this news is Sangamo works in several technology spaces, including previously mentioned genome editing and gene therapy, either would make an advanced type of hair growth therapy we have never seen before. One caveat to mention is the company’s pipeline does not currently display any indication for alopecia, meaning the therapy is not fully developed yet, so it will be some time before trials begin. We certainly hope to hear more from Sangamo Therapeutics as soon as possible about their interesting development for hair growth technology.
Why? Unwanted hair growth (sideburns, for example) is a reported side effect of minoxidil. The belief is that a higher concentration of minoxidil would result in more unwanted hair, which is why women are instructed to use it less often. However, the study in Skin Therapy Letter reports that unwanted hair was more common in 2 percent minoxidil solutions than 5 percent, and women are instructed to use Rogaine’s 2 percent solution twice daily — so what gives?

In the following decades, researchers learned that testosterone does not work alone. An enzyme converts testosterone into a substance called dihydrotestosterone, or DHT, which causes hair follicles to shrink. DHT attacks the dermal papilla, the “brain” of the hair follicle, and is the main cause of male-pattern baldness, which affects more than fifty million men in the United States and also—largely unremarked upon, but true—more than thirty million women.
Many other women, though, start noticing thinning hair on top of their heads. Doctors say the defining sign is a widening of the part. The hairline itself is usually intact, but the hair becomes less dense behind it. Doctors will often run a battery of tests to make sure there are no treatable medical conditions, such as anemia, thyroid problems, tumors, or hormonal problems. "Ninety percent of the time, it's normal," Patel said.
Thanks so much for the guidance! After further research I have to agree with you 100%. Lipogaine Big 3 does containe ketoconazole, which would eliminate the need for Nizoral, however the shampoo only contains a few hair loss/thinning related ingredients. The Big 5 contains 17 and just seems like a better overall product. That plus Nizoral twice weekly seems pretty solid to me.
“People have been trying to sell a baldness cure since the beginning of civilization,” Kuntzman explained. “And the methods by which they try to sell that cure have not changed dramatically. These new companies, they’re trotting out the same promises that people trotted out in Roman times, when they said, ‘Use this hippopotamus fat to grow hair on your head!’ ”
A study led by Dr. Noha Doghaim of Tanta University in Egypt showed that carboxytherapy may be a promising treatment option for both alopecia areata and androgenic alopecia. The study comprised 80 subjects who were treated over the period of three months with either placebo or carboxytherapy.  Both groups found favorable results from the carboxytherapy, however during a follow-up examination the improvements in androgenic alopecia subjects had decreased over time. The researchers noted that continual treatments would be necessary to maintain and bolster the benefits for AGA.
When in doubt, read the usage recommendations found on your hair loss shampoo’s container. Those recommendations are there to ensure that you get the best results from your shampoo without causing damage to your scalp or hair. Also, always pay attention to a product’s list of ingredients to make sure that it doesn’t contain something which may cause an allergic reaction.

The law enhances the FDA’s ability to modernize clinical trial designs and clinical outcome assessments, which will perhaps speed the development and review of novel medical products, including medical countermeasures. The Cures Act also directs the FDA to create so-called “intercenter institutes” to help coordinate  activities in major disease areas between the drug, biologics and device centers and improves the regulation of combination products. An example of one of these centers is the Oncology Center of Excellence.


Dupilumab is FDA approved for treating eczema aka atopic dermatitis and sold under the brand name Dupixent.  As the story goes, a patient with alopecia totalis (a form of areata which leaves a person’s head completely bald) was being treated for eczema by the drug Dupixent. After 6 weeks the patient first began to notice progress in terms of hair growth and at 7 months she had noticeable pigmented hair growth on her scalp. Notably, the patient stopped taking the dupilumab for a period of time and noticed her growth subsided; when she began taking the drug again the hair improved once more. This provides another useful therapy option for patients seeking treatment for AA. One would imagine a topical version would be worthwhile to investigate.
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